Effectiveness of eHealth lifestyle interventions on management of metabolic dysfunction-associated steatotic liver disease: a systematic review and meta-analysis.
4 affiliations
- 1The Department of Nursing, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
- 2The School of Nursing, Sun Yat-sen University, Guangzhou, China.
- 3The Nethersole School of Nursing, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
- 4The Department of Nursing, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China. [email protected].
Abstract
eHealth lifestyle interventions have emerged as promising management strategies for metabolic dysfunction-associated steatotic liver disease (MASLD). Our review aimed to synthesize the most recent evidence to evaluate the effectiveness of eHealth lifestyle interventions on clinical and behavioral outcomes in adults with MASLD. Twelve databases (Medline, Web of Science Core Collection, Embase, Cochrane Central Register of Controlled Trials, ProQuest Health & Medical Collection, CINAHL Complete, Academic Search Complete, Scopus, Emerald, China National Knowledge Infrastructure, Wanfang Data, and VIP Database) were searched from inception to April 2, 2025. Thirteen randomized controlled trials and fifteen quasi-experimental trials comprising 2579 adult patients with MASLD were included. Seven intervention components were identified: goal setting, health education, consultation, self- and device-monitoring, feedback, patient reminders, and social support. Meta-analysis of randomized controlled trials demonstrated that eHealth lifestyle interventions were significantly superior to standard care in reducing weight, body mass index, waist circumference, alanine aminotransferase, aspartate aminotransferase, and γ-glutamyl transferase levels, and improving MASLD status. Improvements in self-management, dietary adherence, physical activity, exercise, and quality of life were also observed. Our findings suggest that ehealth intervention is a better choice for the patients with MASLD to achieve precise and scalable management. PROSPERO CRD420251001470. TRIAL REGISTRATION: PROSPERO CRD420251001470; https://www.crd.york.ac.uk/PROSPERO/view/CRD420251001470 .
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BibTeX
@article{zhao2026effectiveness,
title = {{Effectiveness of eHealth lifestyle interventions on management of metabolic dysfunction-associated steatotic liver disease: a systematic review and meta-analysis.}},
author = {Yangguo Zhao and Xinrui Yang and Yang Bai and Dorothy Ngo Sheung Chan and Caixia Li},
journal = {Nutrition \& diabetes},
year = {2026},
month = jul,
doi = {10.1038/s41387-026-00457-3},
url = {https://europepmc.org/article/MED/42893986},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Effectiveness of eHealth lifestyle interventions on management of metabolic dysfunction-associated steatotic liver disease: a systematic review and meta-analysis.
AU - Yangguo Zhao
AU - Xinrui Yang
AU - Yang Bai
AU - Dorothy Ngo Sheung Chan
AU - Caixia Li
PY - 2026
DA - 2026/07/01
JO - Nutrition & diabetes
DO - 10.1038/s41387-026-00457-3
UR - https://europepmc.org/article/MED/42893986
AB - eHealth lifestyle interventions have emerged as promising management strategies for metabolic dysfunction-associated steatotic liver disease (MASLD). Our review aimed to synthesize the most recent evidence to evaluate the effectiveness of eHealth lifestyle interventions on clinical and behavioral outcomes in adults with MASLD. Twelve databases (Medline, Web of Science Core Collection, Embase, Cochrane Central Register of Controlled Trials, ProQuest Health & Medical Collection, CINAHL Complete, Academic Search Complete, Scopus, Emerald, China National Knowledge Infrastructure, Wanfang Data, and VIP Database) were searched from inception to April 2, 2025. Thirteen randomized controlled trials and fifteen quasi-experimental trials comprising 2579 adult patients with MASLD were included. Seven intervention components were identified: goal setting, health education, consultation, self- and device-monitoring, feedback, patient reminders, and social support. Meta-analysis of randomized controlled trials demonstrated that eHealth lifestyle interventions were significantly superior to standard care in reducing weight, body mass index, waist circumference, alanine aminotransferase, aspartate aminotransferase, and γ-glutamyl transferase levels, and improving MASLD status. Improvements in self-management, dietary adherence, physical activity, exercise, and quality of life were also observed. Our findings suggest that ehealth intervention is a better choice for the patients with MASLD to achieve precise and scalable management. PROSPERO CRD420251001470. TRIAL REGISTRATION: PROSPERO CRD420251001470; https://www.crd.york.ac.uk/PROSPERO/view/CRD420251001470 .
SN - 2044-4052
ER -