Skip to content
DraconiticResearch
Search Sources API
203,203 studies31 sourcesUpdated 56 min ago
Peer-reviewedCC BY 4.0PLOS One

Comparative outcomes of endovascular versus synthetic bypass for isolated superficial femoral artery lesions: A 3-year single-center cohort study

  • Changsung Han1
  • Gwon-Min Kim2
  • Jaewon Choi3
  • Young Jin Tak4
  • Chiseung Lee5
  • Chung Won Lee
  • Miju Bae
  • Il Jae Wang
  • Up Huh
5 affiliations
  1. 1Department of Thoracic and Cardiovascular Surgery, Pusan National University School of Medicine, Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea
  2. 2Medical Research Institute, Pusan National University School of Medicine, Yangsan, Republic of Korea
  3. 3Department of Family Medicine, Pusan National University School of Medicine, Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea
  4. 4In Silico Medicine Lab, Biomedical Research Institute, Pusan National University School of Medicine, Busan, Republic of Korea
  5. 5Department of Emergency Medicine, Pusan National University School of Medicine, Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea
Open at sourceDOICite

Abstract

Peripheral artery disease (PAD) ranges from intermittent claudication to critical limb‑threatening ischemia (CLTI), with <3% of intermittent claudication cases progressing to CLTI. This study aimed to compare the outcomes of percutaneous transluminal angioplasty with stenting (PTAS) and synthetic graft femoropopliteal bypass (FPB) in a homogeneous PAD cohort. A subgroup analysis of TransAtlantic Inter-Society Consensus (TASC) B and C lesions, which lack standardized treatment algorithms, was also performed. We retrospectively analyzed 88 patients with no prior history of vascular interventions in the same limb who were treated for isolated superficial femoral artery lesions between 2016 and 2020 (29 underwent PTAS and 59 underwent FPB). Primary outcomes were reintervention, limb amputation, mortality, and vessel patency (primary, assisted primary, and secondary) over a 3‑year follow‑up. Subgroup analysis was performed to assess differences in treatment outcomes. No statistically significant differences were detected in reintervention, limb amputation, mortality, or patency between the two treatments. For loss of primary patency, the hazard ratio (HR) for FPB versus PTAS was 1.89 (95% confidence interval [CI], 0.76–4.69; log-rank p = 0.146) and 1.23 (95% CI, 0.45–3.38) after adjustment for lesion length and TASC grade. In the TASC B and C subgroup, no significant differences were observed in primary, assisted primary, or secondary patency (log-rank p = 0.809, 0.302, and 0.135, respectively). The study was underpowered to detect modest effects (post-hoc power for primary patency, 34.4%). In this small single-center cohort, no statistically significant difference in 3-year outcomes was detected between PTAS and FPB for isolated superficial femoral artery lesions; clinically meaningful differences cannot be excluded, and the findings should be regarded as hypothesis-generating.

Related

  1. Comparative long-term outcomes of kidney transplantation from donors with isolated microscopic hematuria and thin basement membrane disease versus donors with isolated microscopic hematuria and normal histology: the largest cohort analysis to date.
    Yaser Shah, Dieter Broering, Dalia Obeid +6
    Frontiers in transplantationPeer-reviewedCC BYFull textSurgery & anaesthesiaEurope PMC
  2. Endovascular Management of a Large Isolated Systemic to Pulmonary Artery Collateral (Type B Malinosculation) in a 13-Year-Old: A Case Report
    Meghal Sancheti, Saif Rehman, Alexander V Chalphin +2
    Journal of the Society for Cardiovascular Angiography & InterventionsPeer-reviewedCC BY-NC-ND 4.0Full textEpidemiology & public healthPMCEurope PMC
  3. Isolated systemic arterial supply to the normal lung presenting with massive hemoptysis in a child: CT angiographic diagnosis and endovascular management
    Resham Singh, Vidushi Gupta, Renu Yadav +1
    Journal of Cardiothoracic SurgeryPeer-reviewedCC BY-NC-ND 4.0Full textCardiovascular medicineDOAJPMC
  4. Short-Term Outcomes of Outpatient Endoscopic Resection for Selected Superficial Gastric Neoplasms: A Predominantly EMR-Based Real-World Cohort Study
    Seung-Jun Kim, Chul-Hyun Lim
    Journal of clinical medicinePeer-reviewedCC BYFull textGeneral medicineEurope PMC
  5. Emergency Endovascular Repair of a Large Ruptured Isolated Internal Iliac Artery Aneurysm in a 98-Year-Old Patient: A Case Report
    Raon Kang, Seokjin Hong, Inae Hwang +2
    Journal of Clinical MedicinePeer-reviewedCC BY 4.0General medicineCrossref

Cite

BibTeXRIS
BibTeX
@article{han2026comparative,
  title = {{Comparative outcomes of endovascular versus synthetic bypass for isolated superficial femoral artery lesions: A 3-year single-center cohort study}},
  author = {Changsung Han and Gwon-Min Kim and Jaewon Choi and Young Jin Tak and Chiseung Lee and Chung Won Lee and Miju Bae and Il Jae Wang and Up Huh},
  journal = {PLOS One},
  year = {2026},
  month = nov,
  doi = {10.1371/journal.pone.0361589},
  url = {https://doi.org/10.1371/journal.pone.0361589},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Comparative outcomes of endovascular versus synthetic bypass for isolated superficial femoral artery lesions: A 3-year single-center cohort study
AU  - Changsung Han
AU  - Gwon-Min Kim
AU  - Jaewon Choi
AU  - Young Jin Tak
AU  - Chiseung Lee
AU  - Chung Won Lee
AU  - Miju Bae
AU  - Il Jae Wang
AU  - Up Huh
PY  - 2026
DA  - 2026/11/05
JO  - PLOS One
DO  - 10.1371/journal.pone.0361589
UR  - https://doi.org/10.1371/journal.pone.0361589
AB  - Peripheral artery disease (PAD) ranges from intermittent claudication to critical limb‑threatening ischemia (CLTI), with <3% of intermittent claudication cases progressing to CLTI. This study aimed to compare the outcomes of percutaneous transluminal angioplasty with stenting (PTAS) and synthetic graft femoropopliteal bypass (FPB) in a homogeneous PAD cohort. A subgroup analysis of TransAtlantic Inter-Society Consensus (TASC) B and C lesions, which lack standardized treatment algorithms, was also performed. We retrospectively analyzed 88 patients with no prior history of vascular interventions in the same limb who were treated for isolated superficial femoral artery lesions between 2016 and 2020 (29 underwent PTAS and 59 underwent FPB). Primary outcomes were reintervention, limb amputation, mortality, and vessel patency (primary, assisted primary, and secondary) over a 3‑year follow‑up. Subgroup analysis was performed to assess differences in treatment outcomes. No statistically significant differences were detected in reintervention, limb amputation, mortality, or patency between the two treatments. For loss of primary patency, the hazard ratio (HR) for FPB versus PTAS was 1.89 (95% confidence interval [CI], 0.76–4.69; log-rank p = 0.146) and 1.23 (95% CI, 0.45–3.38) after adjustment for lesion length and TASC grade. In the TASC B and C subgroup, no significant differences were observed in primary, assisted primary, or secondary patency (log-rank p = 0.809, 0.302, and 0.135, respectively). The study was underpowered to detect modest effects (post-hoc power for primary patency, 34.4%). In this small single-center cohort, no statistically significant difference in 3-year outcomes was detected between PTAS and FPB for isolated superficial femoral artery lesions; clinically meaningful differences cannot be excluded, and the findings should be regarded as hypothesis-generating.
SN  - 1932-6203
ER  -