Decreased Brain-Derived Neurotrophic Factor, Increased FK506 Binding Protein 5 and Female Sex Are Associated with Multiscale-Assessed Depressive Symptoms During Heart Failure Decompensation: A Polish Prospective Cohort Study
4 affiliations
- 1Department of Emergency Medicine, Faculty of Health Sciences, Jagiellonian University Medical College, Michalowskiego 12 Street, 31-126 Krakow, Poland
- 2Department of Thromboembolic Disorders, Institute of Cardiology, Jagiellonian University Medical College, 80 Pradnicka Street, 31-202 Krakow, Poland
- 3Department of Coronary Artery Disease and Heart Failure, Saint John Paul II Hospital, 80 Pradnicka Street, 31-202 Krakow, Poland
- 4Department of Coronary Artery Disease and Heart Failure, Institute of Cardiology, Jagiellonian University Medical College, 80 Pradnicka Street, 31-202 Krakow, Poland
Abstract
Background/Objectives: Acute decompensated heart failure (ADHF) may be accompanied by depressive symptoms. Risk factors for a screening diagnosis of depression (SDD) in ADHF are poorly understood. Methods: We enrolled 51 patients with a median age 67 years hospitalized due to ADHF. SDD was determined by the Beck Depression Inventory (BDI) with >12 points or by the Patient Health Questionnaire-9 (PHQ-9) with >11 points. Severe depressive symptoms were diagnosed based on a Hamilton Depression Rating Scale (HDRS) score of >17 points. Baseline neurotrophic potential and stress response were assessed by plasma brain-derived neurotrophic factor (BDNF) and FK506 binding protein 5 (FKBP5), respectively. Results: SDD was identified in 20 (39.2%) patients based on the BDI, in 13 (25.5%) based on the PHQ-9, while severe depressive symptoms according to the HDRS were found in 15 (29.4%) patients. Women had higher BDI (p = 0.044), PHQ-9 (p = 0.022) and HDRS (p = 0.006) scores than men. The BDI score correlated with plasma FKBP5 (r = 0.317, p = 0.025) and inversely with BDNF (r = −0.380, p = 0.006). In multivariable analysis, a higher BDI score was associated with female sex (β = 0.294, p = 0.033) and lower plasma BDNF (β = −0.330, p = 0.015), while a higher HDRS score was associated with female sex (β = 0.312, p = 0.010) and higher plasma FKBP5 (β = 0.388, p = 0.007). Conclusions: In a multi-scale assessment, SDD or severe depressive symptoms were identified in 25–40% of ADHF patients. A higher BDI score was independently associated with lower BDNF, whereas a higher HDRS score was associated with female sex and higher FKBP5.
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BibTeX
@article{zalewska2026decreased,
title = {{Decreased Brain-Derived Neurotrophic Factor, Increased FK506 Binding Protein 5 and Female Sex Are Associated with Multiscale-Assessed Depressive Symptoms During Heart Failure Decompensation: A Polish Prospective Cohort Study}},
author = {Magdalena Zalewska and Karol Nowak and Julia Kościanek and Jadwiga Nessler and Jarosław Zalewski},
journal = {Journal of Clinical Medicine},
year = {2026},
month = oct,
doi = {10.3390/jcm15207893},
url = {https://www.mdpi.com/2077-0383/15/20/7893},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Decreased Brain-Derived Neurotrophic Factor, Increased FK506 Binding Protein 5 and Female Sex Are Associated with Multiscale-Assessed Depressive Symptoms During Heart Failure Decompensation: A Polish Prospective Cohort Study
AU - Magdalena Zalewska
AU - Karol Nowak
AU - Julia Kościanek
AU - Jadwiga Nessler
AU - Jarosław Zalewski
PY - 2026
DA - 2026/10/01
JO - Journal of Clinical Medicine
DO - 10.3390/jcm15207893
UR - https://www.mdpi.com/2077-0383/15/20/7893
AB - Background/Objectives: Acute decompensated heart failure (ADHF) may be accompanied by depressive symptoms. Risk factors for a screening diagnosis of depression (SDD) in ADHF are poorly understood. Methods: We enrolled 51 patients with a median age 67 years hospitalized due to ADHF. SDD was determined by the Beck Depression Inventory (BDI) with >12 points or by the Patient Health Questionnaire-9 (PHQ-9) with >11 points. Severe depressive symptoms were diagnosed based on a Hamilton Depression Rating Scale (HDRS) score of >17 points. Baseline neurotrophic potential and stress response were assessed by plasma brain-derived neurotrophic factor (BDNF) and FK506 binding protein 5 (FKBP5), respectively. Results: SDD was identified in 20 (39.2%) patients based on the BDI, in 13 (25.5%) based on the PHQ-9, while severe depressive symptoms according to the HDRS were found in 15 (29.4%) patients. Women had higher BDI (p = 0.044), PHQ-9 (p = 0.022) and HDRS (p = 0.006) scores than men. The BDI score correlated with plasma FKBP5 (r = 0.317, p = 0.025) and inversely with BDNF (r = −0.380, p = 0.006). In multivariable analysis, a higher BDI score was associated with female sex (β = 0.294, p = 0.033) and lower plasma BDNF (β = −0.330, p = 0.015), while a higher HDRS score was associated with female sex (β = 0.312, p = 0.010) and higher plasma FKBP5 (β = 0.388, p = 0.007). Conclusions: In a multi-scale assessment, SDD or severe depressive symptoms were identified in 25–40% of ADHF patients. A higher BDI score was independently associated with lower BDNF, whereas a higher HDRS score was associated with female sex and higher FKBP5.
SN - 2077-0383
ER -