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Peer-reviewedCC BYJournal of cancer research and clinical oncology

Nucleotide excision repair in tumor response to DNA-damaging anticancer therapies: a comprehensive review.

  • Bartosz Maćkowiak1,2
  • Kamila Ostrowska3,4
  • Julia Kozikowska3,4
  • Katarzyna Kulcenty3
  • Wojciech Golusiński5
  • Wiktoria Suchorska3,6
6 affiliations
  1. 1Radiobiology Laboratory, Greater Poland Cancer Centre, Garbary 15 Street, Poznan, 61-866, Poland. [email protected].
  2. 2Doctoral School of Molecular Medicine, Medical University of Lodz, Haller Square 1, Lodz, 90-624, Poland. [email protected].
  3. 3Radiobiology Laboratory, Greater Poland Cancer Centre, Garbary 15 Street, Poznan, 61-866, Poland.
  4. 4Department of Clinical Chemistry and Molecular Diagnostics, Poznan University of Medical Sciences, Rokietnicka 3 Street, Poznan, 60-806, Poland.
  5. 5Department of Head and Neck Surgery, Poznan University of Medical Sciences, Garbary 15 Street, Poznan, 61-866, Poland.
  6. 6Department of Electroradiology, Poznan University of Medical Sciences, Fredry 10 Street, Poznan, 61-701, Poland.
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Abstract

Nucleotide excision repair (NER) is a critical DNA repair pathway responsible for removing bulky, helix-distorting DNA lesions, including ultraviolet radiation-induced photoproducts and platinum drug-DNA adducts. This review provides a comprehensive overview of current understanding of NER in cancer, with particular emphasis on its role in therapeutic response. We discuss the molecular mechanisms of DNA repair in cancer, the significance of NER in platinum-based therapies, results from in vitro studies across various cancer types, findings from patient-based studies, and outcomes from clinical trials. Special attention is given to ERCC1, ERCC2/XPD, XPA, and XPC molecules as potential biomarkers of treatment response and therapeutic targets, and incorporating the most recent discoveries regarding NER inhibitors, mutational signatures, and synthetic lethality-based approaches.

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Cite

BibTeXRIS
BibTeX
@article{mackowiak2026nucleotide,
  title = {{Nucleotide excision repair in tumor response to DNA-damaging anticancer therapies: a comprehensive review.}},
  author = {Bartosz Maćkowiak and Kamila Ostrowska and Julia Kozikowska and Katarzyna Kulcenty and Wojciech Golusiński and Wiktoria Suchorska},
  journal = {Journal of cancer research and clinical oncology},
  year = {2026},
  month = jul,
  doi = {10.1007/s00432-026-06563-0},
  url = {https://europepmc.org/article/MED/42894078},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Nucleotide excision repair in tumor response to DNA-damaging anticancer therapies: a comprehensive review.
AU  - Bartosz Maćkowiak
AU  - Kamila Ostrowska
AU  - Julia Kozikowska
AU  - Katarzyna Kulcenty
AU  - Wojciech Golusiński
AU  - Wiktoria Suchorska
PY  - 2026
DA  - 2026/07/01
JO  - Journal of cancer research and clinical oncology
DO  - 10.1007/s00432-026-06563-0
UR  - https://europepmc.org/article/MED/42894078
AB  - Nucleotide excision repair (NER) is a critical DNA repair pathway responsible for removing bulky, helix-distorting DNA lesions, including ultraviolet radiation-induced photoproducts and platinum drug-DNA adducts. This review provides a comprehensive overview of current understanding of NER in cancer, with particular emphasis on its role in therapeutic response. We discuss the molecular mechanisms of DNA repair in cancer, the significance of NER in platinum-based therapies, results from in vitro studies across various cancer types, findings from patient-based studies, and outcomes from clinical trials. Special attention is given to ERCC1, ERCC2/XPD, XPA, and XPC molecules as potential biomarkers of treatment response and therapeutic targets, and incorporating the most recent discoveries regarding NER inhibitors, mutational signatures, and synthetic lethality-based approaches.
SN  - 0171-5216
SN  - 1432-1335
ER  -