Skip to content
DraconiticResearch
Search Sources API
203,234 studies31 sourcesUpdated 39 min ago
Peer-reviewedCC BY 4.0Platelets

Developmental differences in platelet P-selectin expression modulate neonatal monocyte inflammatory responses

  • Erin Soule-Albridge1
  • Emily Flahardy1
  • Henry A. Feldman1,2,3
  • Natalie Kane1
  • Kimberley Banfield1
  • Amalia El Nems1
  • Jesselin Romero Escobar1
  • Martha Sola-Visner1,2
  • Patricia Davenport1,2
  1. 1Boston Children’s Hospital, Division of Newborn Medicine, Boston, MA, USA
  2. 2Department of Pediatrics, Harvard Medical School, Boston, MA, USA
  3. 3Biostatistics and Research Design Center, Boston Children’s Hospital, Boston, MA, USA
Read full textPDFDOICite

Abstract

Neonatal and adult platelets are functionally different, with neonatal platelets being comparatively hypo-reactive to multiple platelet agonists. When transfused, neonates receive platelets from adult donors, resulting in a cellular developmental mismatch. Platelets are key regulators of the monocyte inflammatory response, yet how the developmental stage of the platelet affects this response is unknown. In this study, we modeled this developmental mismatch in vitro to investigate the neonatal (cord blood) monocyte inflammatory response and migratory phenotype after exposure to either neonatal (cord blood) or adult platelets. Adult platelets expressed more P-selectin on the surface and released more beta-2-microglobulin (B2M) after activation compared to neonatal platelets. While exposure to platelets of either developmental stage increased the release of IL-8 and MCP-1 from neonatal monocytes to a similar degree, exposure to adult platelets induced significantly greater monocyte CCR2 and CCR5 surface expression, consistent with a pro-migratory monocyte phenotype. Blocking P-selectin/PSGL-1 interactions had no effect on platelet induced monocyte cytokine release but completely abrogated monocyte CCR2 and CCR5 surface upregulation. These findings suggest that the monocyte pro-migratory phenotype is regulated by P-selectin exposure, which is influenced by the platelet developmental stage, while monocyte cytokine release is independent of platelet P-selectin expression or developmental stage.

Related

  1. Age-dependent differences in SARS-CoV-2 entry-factor expression and innate immune responses between pediatric and adult liver organoids
    Tianchen Xue, Jie Hu, Zhe Liu +7
    Frontiers in Public HealthPeer-reviewedCC BY 4.0Full textInfectious diseaseCrossrefDOAJEurope PMC
  2. Population differences in embryonic developmental timing in the lizard Diploderma swinhonis
    Jung-Ya Hsu, Chun-Chia Chou, Chen-Pan Liao +2
    PLOS OnePeer-reviewedCC BY 4.0Full textPhysiologyPLOS
  3. Activation of Platelet Caspase-1 and P-Selectin Over-Expression in Sickle Cell Disease Patients: An Involvement of NLRP3 Inflammasome?
    Livia Claude, Frédéric Martino, Lydiane Mordier +6
    Journal of cellular and molecular medicinePeer-reviewedCC BYFull textHuman geneticsEurope PMC
  4. Cannabigerol Modulates Blood Pressure and Vascular Reactivity in a Rat Model of Hypertension and Platelet Responses in Human Blood In Vitro
    Anna Krzyżewska, Krzysztof Mińczuk, Tomasz Misztal +2
    Molecules (Basel, Switzerland)Peer-reviewedCC BYFull textPharmacology & toxicologyEurope PMCCrossref
  5. Incompletely penetrant protein-truncating variants confer developmental disorder risk through partial reductions in gene expression
    J. E. Hampstead, E. Delage, G. Khazeeva +13
    medRxivPreprintPublic domainFull textHuman geneticsmedRxiv

Cite

BibTeXRIS
BibTeX
@article{soulealbridge2026developmental,
  title = {{Developmental differences in platelet P-selectin expression modulate neonatal monocyte inflammatory responses}},
  author = {Erin Soule-Albridge and Emily Flahardy and Henry A. Feldman and Natalie Kane and Kimberley Banfield and Amalia El Nems and Jesselin Romero Escobar and Martha Sola-Visner and Patricia Davenport},
  journal = {Platelets},
  year = {2026},
  month = sep,
  doi = {10.1080/09537104.2026.2726287},
  url = {https://doi.org/10.1080/09537104.2026.2726287},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Developmental differences in platelet P-selectin expression modulate neonatal monocyte inflammatory responses
AU  - Erin Soule-Albridge
AU  - Emily Flahardy
AU  - Henry A. Feldman
AU  - Natalie Kane
AU  - Kimberley Banfield
AU  - Amalia El Nems
AU  - Jesselin Romero Escobar
AU  - Martha Sola-Visner
AU  - Patricia Davenport
PY  - 2026
DA  - 2026/09/22
JO  - Platelets
DO  - 10.1080/09537104.2026.2726287
UR  - https://doi.org/10.1080/09537104.2026.2726287
AB  - Neonatal and adult platelets are functionally different, with neonatal platelets being comparatively hypo-reactive to multiple platelet agonists. When transfused, neonates receive platelets from adult donors, resulting in a cellular developmental mismatch. Platelets are key regulators of the monocyte inflammatory response, yet how the developmental stage of the platelet affects this response is unknown. In this study, we modeled this developmental mismatch in vitro to investigate the neonatal (cord blood) monocyte inflammatory response and migratory phenotype after exposure to either neonatal (cord blood) or adult platelets. Adult platelets expressed more P-selectin on the surface and released more beta-2-microglobulin (B2M) after activation compared to neonatal platelets. While exposure to platelets of either developmental stage increased the release of IL-8 and MCP-1 from neonatal monocytes to a similar degree, exposure to adult platelets induced significantly greater monocyte CCR2 and CCR5 surface expression, consistent with a pro-migratory monocyte phenotype. Blocking P-selectin/PSGL-1 interactions had no effect on platelet induced monocyte cytokine release but completely abrogated monocyte CCR2 and CCR5 surface upregulation. These findings suggest that the monocyte pro-migratory phenotype is regulated by P-selectin exposure, which is influenced by the platelet developmental stage, while monocyte cytokine release is independent of platelet P-selectin expression or developmental stage.
SN  - 0953-7104
SN  - 1369-1635
ER  -