Peer-reviewedCC BYJournal of Spectroscopy
Electrospray Tandem Mass Spectrometry of 3′‐azido‐2′,3′dideoxythymidine and of a Novel Series of 3′‐azido‐2′,3′,4′‐trideoxy‐4′thio‐5‐halogenouridines and their Respective α‐Anomers
Abstract
Electrospray mass spectrometry has aided the structural characterization of 3′‐azido‐2′,3′‐dideoxythymidine (AZI) and the novel series of 3′‐azido‐2′,3′,4′trideoxy‐4′‐thio‐S‐(bromo, chi oro or fluoro )uridine nucleosides and their respective α.anomers. Low energy CAD MS/MS analysis of the protonated molecules [M+H]+ confmned the predicted fragmentation route for AZT and a series of related 4′‐thio‐S‐halogenouridines. This MSIMS study also provided characteristic fingerprint patterns which permitted differentiation of anomers within the series of 3′‐azido‐2′ ,3′ ,4′ ‐trideoxy‐4′ ‐thio‐S‐halogenouridine nucleosides.
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BibTeX
@article{banoub2026electrospray,
title = {{Electrospray Tandem Mass Spectrometry of 3′‐azido‐2′,3′dideoxythymidine and of a Novel Series of 3′‐azido‐2′,3′,4′‐trideoxy‐4′thio‐5‐halogenouridines and their Respective α‐Anomers}},
author = {Joseph Banoub and Emmanuel Gentil and Bougrine Tber and Nour-Eddine Fahmi and Gino Ronco and Pierre Villa and Grahame Mackenzie},
journal = {Journal of Spectroscopy},
year = {2026},
month = sep,
doi = {10.1155/1994/817395},
url = {https://hal.science/hal-05742268v1},
note = {CC BY},
}
RIS
TY - JOUR
TI - Electrospray Tandem Mass Spectrometry of 3′‐azido‐2′,3′dideoxythymidine and of a Novel Series of 3′‐azido‐2′,3′,4′‐trideoxy‐4′thio‐5‐halogenouridines and their Respective α‐Anomers
AU - Joseph Banoub
AU - Emmanuel Gentil
AU - Bougrine Tber
AU - Nour-Eddine Fahmi
AU - Gino Ronco
AU - Pierre Villa
AU - Grahame Mackenzie
PY - 2026
DA - 2026/09/08
JO - Journal of Spectroscopy
DO - 10.1155/1994/817395
UR - https://hal.science/hal-05742268v1
AB - Electrospray mass spectrometry has aided the structural characterization of 3′‐azido‐2′,3′‐dideoxythymidine (AZI) and the novel series of 3′‐azido‐2′,3′,4′trideoxy‐4′‐thio‐S‐(bromo, chi oro or fluoro )uridine nucleosides and their respective α.anomers. Low energy CAD MS/MS analysis of the protonated molecules [M+H]+ confmned the predicted fragmentation route for AZT and a series of related 4′‐thio‐S‐halogenouridines. This MSIMS study also provided characteristic fingerprint patterns which permitted differentiation of anomers within the series of 3′‐azido‐2′ ,3′ ,4′ ‐trideoxy‐4′ ‐thio‐S‐halogenouridine nucleosides.
SN - 2314-4920
SN - 2314-4939
ER -