The impact of histological subtype on positive surgical margins in patients with renal cell carcinoma undergoing robot-assisted partial nephrectomy: a multicenter retrospective cohort study using propensity score matching (the MSUG 94 group)
7 affiliations
- 1Department of Urology, Toranomon Hospital
- 2Department of Urology, Gifu University Graduate School of Medicine
- 3Department of Urology, Yokohama City University
- 4Department of Nephro-Urologic Surgery and Andrology, Mie University Graduate School of Medicine
- 5Department of Urology, University of Toyama
- 6Department of Urology, Dokkyo Medical University Saitama Medical Center
- 7Department of Urology, Seirei Hamamatsu General Hospital
Abstract
This study aimed to examine the impact of histological differences on positive surgical margins (PSM) and postoperative renal function in patients with renal cell carcinoma (RCC) who underwent robot-assisted partial nephrectomy (RAPN). This multicenter retrospective cohort study included patients with RCC who underwent RAPN at eight Japanese facilities between March 2016 and November 2023. The enrolled patients who underwent RAPN were divided into those with clear cell RCC (ccRCC group) and those with other histological subtypes (non-ccRCC group). The primary endpoint was to determine the differences in PSM rates according to histological type among patients who underwent RAPN. Secondary endpoint was the chronological assessment of renal function in patients undergoing RAPN, which was categorized according to histological type. To ensure a balance between the two groups with respect to variables that may influence perioperative outcomes, 3:1 propensity score matching was performed using logistic regression. Following propensity score matching at a 3:1 ratio, the analysis included 735 ccRCC and 245 non-ccRCC patients. No significant association was identified between the histological subtypes and PSM in multivariate analysis. Despite a decline in renal function of approximately 10% in both groups postoperatively, no significant difference was observed between the groups in the chronological changes in renal function over time. There was no statistically significant differences in the incidence of PSM based on histological type among the study groups nor substantial variations in postoperative renal function.
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BibTeX
@article{oka2026impact,
title = {{The impact of histological subtype on positive surgical margins in patients with renal cell carcinoma undergoing robot-assisted partial nephrectomy: a multicenter retrospective cohort study using propensity score matching (the MSUG 94 group)}},
author = {Suguru Oka and Koji Iinuma and Tomoki Taniguchi and Kentaro Muraoka and Kohei Nishikawa and Yoshinori Ikehata and Kiyoshi Setoguchi and Akira Fujisaki and Shinji Urakami and Kazuhide Makiyama and Takahiro Inoue and Hiroshi Kitamura and Kazutaka Saito and Takuya Koie},
journal = {Scientific Reports},
year = {2026},
month = jul,
doi = {10.1038/s41598-026-63358-6},
url = {https://doi.org/10.1038/s41598-026-63358-6},
note = {CC BY},
}
RIS
TY - JOUR
TI - The impact of histological subtype on positive surgical margins in patients with renal cell carcinoma undergoing robot-assisted partial nephrectomy: a multicenter retrospective cohort study using propensity score matching (the MSUG 94 group)
AU - Suguru Oka
AU - Koji Iinuma
AU - Tomoki Taniguchi
AU - Kentaro Muraoka
AU - Kohei Nishikawa
AU - Yoshinori Ikehata
AU - Kiyoshi Setoguchi
AU - Akira Fujisaki
AU - Shinji Urakami
AU - Kazuhide Makiyama
AU - Takahiro Inoue
AU - Hiroshi Kitamura
AU - Kazutaka Saito
AU - Takuya Koie
PY - 2026
DA - 2026/07/01
JO - Scientific Reports
DO - 10.1038/s41598-026-63358-6
UR - https://doi.org/10.1038/s41598-026-63358-6
AB - This study aimed to examine the impact of histological differences on positive surgical margins (PSM) and postoperative renal function in patients with renal cell carcinoma (RCC) who underwent robot-assisted partial nephrectomy (RAPN). This multicenter retrospective cohort study included patients with RCC who underwent RAPN at eight Japanese facilities between March 2016 and November 2023. The enrolled patients who underwent RAPN were divided into those with clear cell RCC (ccRCC group) and those with other histological subtypes (non-ccRCC group). The primary endpoint was to determine the differences in PSM rates according to histological type among patients who underwent RAPN. Secondary endpoint was the chronological assessment of renal function in patients undergoing RAPN, which was categorized according to histological type. To ensure a balance between the two groups with respect to variables that may influence perioperative outcomes, 3:1 propensity score matching was performed using logistic regression. Following propensity score matching at a 3:1 ratio, the analysis included 735 ccRCC and 245 non-ccRCC patients. No significant association was identified between the histological subtypes and PSM in multivariate analysis. Despite a decline in renal function of approximately 10% in both groups postoperatively, no significant difference was observed between the groups in the chronological changes in renal function over time. There was no statistically significant differences in the incidence of PSM based on histological type among the study groups nor substantial variations in postoperative renal function.
SN - 2045-2322
ER -