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Peer-reviewedCC BY 4.0International Journal of Molecular Sciences

Lifespan Extension and Increased Resistance to Environmental Stressors Induced by 5-Hydroxy-4-phenylfuran-2(5H)-one in Caenorhabditis elegans

  • Yasunori Okuma1,2
  • Kayo Yasuda3
  • Sumino Yanase4
  • Naoaki Ishii3
  • Yoshio Tsujino2
4 affiliations
  1. 1Research Centre, Arimino Co., Ltd., 25-5 Miyako, Namegawa-machi, Hiki-gun 355-0812, Saitama, Japan
  2. 2Graduate School of Science, Technology and Innovation, Kobe University, Kobe-shi 657-8501, Hyogo, Japan
  3. 3Department of Health Management, School of Health Studies, Tokai University, Hiratsuka-shi 259-1292, Kanagawa, Japan
  4. 4Department of Health Science, School of Sports & Health Science, Daito Bunka University, Higashimatsuyama-shi 355-8501, Saitama, Japan
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Abstract

This study investigated whether 5-hydroxy-4-phenylfuran-2(5H)-one (FG1), a bioactive compound derived from aromatic vinegar, exerts anti-ageing effects in the nematode Caenorhabditis elegans. FG1 treatment significantly extended both mean and maximum lifespan and preserved locomotor activity during ageing. Transcriptomic analysis revealed that FG1 upregulated genes associated with detoxification, glutathione metabolism, oxidative phosphorylation, and longevity-regulating pathways. Gene ontology and pathway analyses suggested activation of antioxidant and xenobiotic defence systems. FG1 significantly extended lifespan in wild-type worms, whereas no statistically significant lifespan extension was detected in SKN-1-deficient worms, suggesting a possible involvement of SKN-1 signalling in the lifespan-extending effect of FG1. FG1 also reduced lipofuscin and hydrogen peroxide accumulation in vivo and enhanced resistance to heat- and paraquat-induced oxidative stress. Overall, these findings suggest that the effects of FG1 on longevity and stress resistance are associated with changes in antioxidant and detoxification responses, although the contribution of SKN-1 requires further investigation.

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Cite

BibTeXRIS
BibTeX
@article{okuma2026lifespan,
  title = {{Lifespan Extension and Increased Resistance to Environmental Stressors Induced by 5-Hydroxy-4-phenylfuran-2(5H)-one in Caenorhabditis elegans}},
  author = {Yasunori Okuma and Kayo Yasuda and Sumino Yanase and Naoaki Ishii and Yoshio Tsujino},
  journal = {International Journal of Molecular Sciences},
  year = {2026},
  month = oct,
  doi = {10.3390/ijms27209208},
  url = {https://www.mdpi.com/1422-0067/27/20/9208},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Lifespan Extension and Increased Resistance to Environmental Stressors Induced by 5-Hydroxy-4-phenylfuran-2(5H)-one in Caenorhabditis elegans
AU  - Yasunori Okuma
AU  - Kayo Yasuda
AU  - Sumino Yanase
AU  - Naoaki Ishii
AU  - Yoshio Tsujino
PY  - 2026
DA  - 2026/10/16
JO  - International Journal of Molecular Sciences
DO  - 10.3390/ijms27209208
UR  - https://www.mdpi.com/1422-0067/27/20/9208
AB  - This study investigated whether 5-hydroxy-4-phenylfuran-2(5H)-one (FG1), a bioactive compound derived from aromatic vinegar, exerts anti-ageing effects in the nematode Caenorhabditis elegans. FG1 treatment significantly extended both mean and maximum lifespan and preserved locomotor activity during ageing. Transcriptomic analysis revealed that FG1 upregulated genes associated with detoxification, glutathione metabolism, oxidative phosphorylation, and longevity-regulating pathways. Gene ontology and pathway analyses suggested activation of antioxidant and xenobiotic defence systems. FG1 significantly extended lifespan in wild-type worms, whereas no statistically significant lifespan extension was detected in SKN-1-deficient worms, suggesting a possible involvement of SKN-1 signalling in the lifespan-extending effect of FG1. FG1 also reduced lipofuscin and hydrogen peroxide accumulation in vivo and enhanced resistance to heat- and paraquat-induced oxidative stress. Overall, these findings suggest that the effects of FG1 on longevity and stress resistance are associated with changes in antioxidant and detoxification responses, although the contribution of SKN-1 requires further investigation.
SN  - 1422-0067
ER  -