Safety and feasibility of peripherally inserted central catheter (PICC) placement in patients with newly diagnosed acute leukemia: A single-center retrospective study
- 1Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025 China
Abstract
Patients with newly diagnosed acute leukemia are at increased risk of bleeding during vascular access because of thrombocytopenia and coagulopathy. The primary objective of this single-center retrospective study (November 2023–August 2024; Ruijin Hospital) was to evaluate the feasibility and safety of a peripherally inserted central catheter (PICC) puncture and nursing protocol incorporating ultrasound-guided Seldinger puncture, controlled sheath withdrawal with gauze-assisted compression, and localized hemostatic dressing in 101 patients prior to chemotherapy. The first-attempt success rate was 95.1%. At 24 h, active oozing occurred in 14 patients (13.9%); all events were CTCAE grade 1–2 and were controlled with local measures. Platelet count (PLT; OR = 0.972, P = 0.029) and fibrinogen (Fg; OR = 0.594, P = 0.049) were independent predictors of bleeding. On ROC analysis, PLT showed greater predictive value (AUC = 0.762, 95% CI 0.628–0.880). Catheter malposition and thrombosis each occurred in 1.0% of patients (CTCAE grade 2 and grade 1, respectively); no phlebitis, catheter-related infection, or grade ≥ 3 adverse events were reported. The technique was safe and feasible, and PLT and Fg helped predict bleeding risk. Prospective multicenter validation is warranted.
Supplementary Information: The online version contains supplementary material available at https://doi.org/10.1007/s00277-026-07241-4.
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BibTeX
@article{wei2026safety,
title = {{Safety and feasibility of peripherally inserted central catheter (PICC) placement in patients with newly diagnosed acute leukemia: A single-center retrospective study}},
author = {Yulei Wei and Xiaohong Zhang and Fei Zhao and Yang He and Jinlian Hu},
journal = {Annals of Hematology},
year = {2026},
month = aug,
doi = {10.1007/s00277-026-07241-4},
url = {https://doi.org/10.1007/s00277-026-07241-4},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Safety and feasibility of peripherally inserted central catheter (PICC) placement in patients with newly diagnosed acute leukemia: A single-center retrospective study
AU - Yulei Wei
AU - Xiaohong Zhang
AU - Fei Zhao
AU - Yang He
AU - Jinlian Hu
PY - 2026
DA - 2026/08/12
JO - Annals of Hematology
DO - 10.1007/s00277-026-07241-4
UR - https://doi.org/10.1007/s00277-026-07241-4
AB - Patients with newly diagnosed acute leukemia are at increased risk of bleeding during vascular access because of thrombocytopenia and coagulopathy. The primary objective of this single-center retrospective study (November 2023–August 2024; Ruijin Hospital) was to evaluate the feasibility and safety of a peripherally inserted central catheter (PICC) puncture and nursing protocol incorporating ultrasound-guided Seldinger puncture, controlled sheath withdrawal with gauze-assisted compression, and localized hemostatic dressing in 101 patients prior to chemotherapy. The first-attempt success rate was 95.1%. At 24 h, active oozing occurred in 14 patients (13.9%); all events were CTCAE grade 1–2 and were controlled with local measures. Platelet count (PLT; OR = 0.972, P = 0.029) and fibrinogen (Fg; OR = 0.594, P = 0.049) were independent predictors of bleeding. On ROC analysis, PLT showed greater predictive value (AUC = 0.762, 95% CI 0.628–0.880). Catheter malposition and thrombosis each occurred in 1.0% of patients (CTCAE grade 2 and grade 1, respectively); no phlebitis, catheter-related infection, or grade ≥ 3 adverse events were reported. The technique was safe and feasible, and PLT and Fg helped predict bleeding risk. Prospective multicenter validation is warranted. Supplementary Information: The online version contains supplementary material available at https://doi.org/10.1007/s00277-026-07241-4.
SN - 0939-5555
SN - 1432-0584
ER -