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Peer-reviewedCC BYRevista latino-americana de enfermagem

Associations between biomarkers and clinical outcome in people hospitalized with HIV: a retrospective cohort

  • Jarbas da Silva Ziani1
  • Jenifer Härter2
  • Bibiana Letícia Nogara3
  • Francielle Liz Monteiro3
  • Laís Mara Caetano da Silva Corcini4
  • Cláudia Zamberlan5
5 affiliations
  1. 1Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.
  2. 2Universidade Federal do Pampa, Departamento de Enfermagem, Uruguaiana, RS, Brazil.
  3. 3Universidade Franciscana, Departamento de Biomedicina, Santa Maria, RS, Brazil.
  4. 4Universidade Federal de Santa Maria, Centro de Ciências da Saúde, Santa Maria, RS, Brazil.
  5. 5Universidade Franciscana, Departamento de Enfermagem, Santa Maria, RS, Brazil.
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Abstract

Objective

to verify the associations between biomarkers and their relationship with the clinical outcome of people hospitalized with HIV infection.Method

retrospective cohort of documentary character. People hospitalized with a diagnosis of HIV infection were included, with hospital discharge and death as outcomes. Sociodemographic, clinical, and biomarker variables were evaluated using Fisher's exact analysis, Pearson's chi-square, and Cox regression.Results

among the 102 participants analyzed, 27 (26.5%) died during hospitalization. Among the factors associated with the risk of death, viral load greater than 1000 copies/mL (HR: 3.99; p = <0.023), CD4+ T lymphocyte count up to 200 copies/mm³ (HR: 1.92; p = <0.035), glucose greater than 126 mg/dL (HR: 5.40; p = <0.017), creatinine greater than 1.20 mg/dL (HR: 9.75; p = <0.012) and triglycerides above 201 mg/dL (HR: 11.75; p = <0.000) stand out.Conclusion

it was found that immunological, metabolic, renal and lipid biomarkers play an essential role in the prognostic evaluation of people hospitalized with HIV infection, being strongly associated with the risk of death.

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Cite

BibTeXRIS
BibTeX
@article{ziani2026associations,
  title = {{Associations between biomarkers and clinical outcome in people hospitalized with HIV: a retrospective cohort}},
  author = {Jarbas da Silva Ziani and Jenifer Härter and Bibiana Letícia Nogara and Francielle Liz Monteiro and Laís Mara Caetano da Silva Corcini and Cláudia Zamberlan},
  journal = {Revista latino-americana de enfermagem},
  year = {2026},
  month = oct,
  doi = {10.1590/1518-8345.7473.4952},
  url = {https://europepmc.org/article/PMC/PMC13679911},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Associations between biomarkers and clinical outcome in people hospitalized with HIV: a retrospective cohort
AU  - Jarbas da Silva Ziani
AU  - Jenifer Härter
AU  - Bibiana Letícia Nogara
AU  - Francielle Liz Monteiro
AU  - Laís Mara Caetano da Silva Corcini
AU  - Cláudia Zamberlan
PY  - 2026
DA  - 2026/10/19
JO  - Revista latino-americana de enfermagem
DO  - 10.1590/1518-8345.7473.4952
UR  - https://europepmc.org/article/PMC/PMC13679911
AB  - Objective  to verify the associations between biomarkers and their relationship with the clinical outcome of people hospitalized with HIV infection.Method  retrospective cohort of documentary character. People hospitalized with a diagnosis of HIV infection were included, with hospital discharge and death as outcomes. Sociodemographic, clinical, and biomarker variables were evaluated using Fisher's exact analysis, Pearson's chi-square, and Cox regression.Results  among the 102 participants analyzed, 27 (26.5%) died during hospitalization. Among the factors associated with the risk of death, viral load greater than 1000 copies/mL (HR: 3.99; p = <0.023), CD4+ T lymphocyte count up to 200 copies/mm³ (HR: 1.92; p = <0.035), glucose greater than 126 mg/dL (HR: 5.40; p = <0.017), creatinine greater than 1.20 mg/dL (HR: 9.75; p = <0.012) and triglycerides above 201 mg/dL (HR: 11.75; p = <0.000) stand out.Conclusion  it was found that immunological, metabolic, renal and lipid biomarkers play an essential role in the prognostic evaluation of people hospitalized with HIV infection, being strongly associated with the risk of death.
SN  - 0104-1169
SN  - 1518-8345
ER  -