Significant Alterations in Phospholipid Content and Composition Contributing to Metabolic Dysfunction in ADMSC-Derived Adipocytes
4 affiliations
- 1Department of Physiology, Medical University of Bialystok, Mickiewicza 2C, 15-222 Białystok, Poland
- 2Faculty of Health Sciences, University of Lomza, 18-400 Lomza, Poland
- 3Department of Physical Chemistry, Faculty of Chemistry, University of Bialystok, Ciolkowskiego 1K, 15-245 Białystok, Poland
- 4Doctoral School of Exact and Natural Sciences, University of Bialystok, Ciolkowskiego 1K, 15-245 Białystok, Poland
Abstract
Adipose-derived mesenchymal stem cells (ADMSCs) are a crucial source of new adipocytes and play a significant role in regulating adipose tissue physiology. Interestingly, mature adipocytes differentiated from the ADMSCs maintain some characteristic features of their respective depots as well as the metabolic status of the donor patients. The above is true with respect to the cells’ secretory profile and their glycerolipid and sphingolipid composition. In the current paper, we focused our attention on the phospholipid profile of the adipocytes derived from ADMSCs, with a particular emphasis placed on how obesity and metabolic syndrome affect their composition. Surprisingly, the cells displayed a significantly greater (even up to 10-fold) overall phospholipid concentration when compared with the primary human adipocytes described in the literature. The phenomenon may be explained by a geometrical property known as surface-to-volume ratio, which dictates that the total surface area of many small cells (our adipocytes) is greater than the total area of less numerous but more voluminous cells in vivo. Interestingly, also a donor’s metabolic status can influence the characteristics of these fat cells. The study found that subcutaneous adipocytes, when derived from patients with obesity and metabolic syndrome, had an increased concentration of phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylinositol (PI), and sphingomyelin (SM). The above-mentioned changes often reflect the ones found in vivo and may well be the early metabolic disarrangements that occur in the progress of obesity.
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BibTeX
@article{lukaszuk2026significant,
title = {{Significant Alterations in Phospholipid Content and Composition Contributing to Metabolic Dysfunction in ADMSC-Derived Adipocytes}},
author = {Bartłomiej Łukaszuk and Elżbieta Supruniuk and Jan Górski and Monika Naumowicz and Marcin Zając and Adrian Chabowski and Agnieszka Mikłosz},
journal = {Cells},
year = {2026},
month = sep,
doi = {10.3390/cells15191725},
url = {https://europepmc.org/article/PMC/PMC13664016},
note = {CC BY},
}
RIS
TY - JOUR
TI - Significant Alterations in Phospholipid Content and Composition Contributing to Metabolic Dysfunction in ADMSC-Derived Adipocytes
AU - Bartłomiej Łukaszuk
AU - Elżbieta Supruniuk
AU - Jan Górski
AU - Monika Naumowicz
AU - Marcin Zając
AU - Adrian Chabowski
AU - Agnieszka Mikłosz
PY - 2026
DA - 2026/09/22
JO - Cells
DO - 10.3390/cells15191725
UR - https://europepmc.org/article/PMC/PMC13664016
AB - Adipose-derived mesenchymal stem cells (ADMSCs) are a crucial source of new adipocytes and play a significant role in regulating adipose tissue physiology. Interestingly, mature adipocytes differentiated from the ADMSCs maintain some characteristic features of their respective depots as well as the metabolic status of the donor patients. The above is true with respect to the cells’ secretory profile and their glycerolipid and sphingolipid composition. In the current paper, we focused our attention on the phospholipid profile of the adipocytes derived from ADMSCs, with a particular emphasis placed on how obesity and metabolic syndrome affect their composition. Surprisingly, the cells displayed a significantly greater (even up to 10-fold) overall phospholipid concentration when compared with the primary human adipocytes described in the literature. The phenomenon may be explained by a geometrical property known as surface-to-volume ratio, which dictates that the total surface area of many small cells (our adipocytes) is greater than the total area of less numerous but more voluminous cells in vivo. Interestingly, also a donor’s metabolic status can influence the characteristics of these fat cells. The study found that subcutaneous adipocytes, when derived from patients with obesity and metabolic syndrome, had an increased concentration of phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylinositol (PI), and sphingomyelin (SM). The above-mentioned changes often reflect the ones found in vivo and may well be the early metabolic disarrangements that occur in the progress of obesity.
SN - 2073-4409
ER -