Effects of ginger intervention on anthropometric and body composition indices in patients with type 2 diabetes: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials.
8 affiliations
- 1Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
- 2Nutrition and Metabolic Diseases Research Center, Clinical Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
- 3Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
- 4Student Research and technology Committee, Faculty of Health and Nutrition, , Bushehr University of Medical Sciences, Bushehr, Iran.
- 5Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
- 6Department of Cellular and Molecular Nutrition, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
- 7Nutrition and Metabolic Diseases Research Center, Clinical Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. [email protected].
- 8Department of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz-Iran-Golestan Highway, Ahvaz, 6135715794, Iran. [email protected].
Abstract
Background and aims
Evidence on the effects of ginger supplementation on anthropometric and body composition indices in adults with type 2 diabetes mellitus (T2DM) is inconsistent, and the certainty of this evidence has not been fully evaluated. This study aimed to systematically review and meta-analyze randomized controlled trials assessing these effects.Methods
PubMed, Scopus, and Web of Science were searched until October 5, 2025. We used random-effects meta-analysis to find average differences with 95% CIs. Study quality and evidence certainty were checked with Cochrane RoB-2 tool and GRADE approach. Subgroup, meta-regression, sensitivity, and publication bias analyses were also done.Results
This meta-analysis included 692 participants from 12 RCTs. Ginger supplementation significantly reduced body mass index (BMI) (- 0.24 kg/m²; 95% CI: -0.48, - 0.00; p = 0.043) and body fat percentage (BF%) (- 1.44%; 95% CI: -2.49, - 0.38; p = 0.007), while no significant effects were observed on body weight (BW), waist circumference (WC), hip circumference (HC), or waist-to-hip ratio (WHR). Bias assessment showed 9 studies with some concerns, 1 low, and 2 high risk. Evidence quality was moderate for 4 outcomes (BMI, WHR, HC, BF%), low for WC, and high for BW.Conclusion
Ginger reduced BMI and BF%, with no significant change in BW, WHR, HC, or WC.Trial registration
This study was prospectively registered in PROSPERO (CRD420251162956).
Related
- Effect of a free sugar-restricted diet on anthropometric parameters, lipid profile, and glycemic control in women with polycystic ovary syndrome: a randomized controlled trial.
- Efficacy of a weighted-vest aerobic dance intervention for enhancing lower extremity strength and mobility in older adults: a randomized controlled trial
- Culturally adapted home-based intervention to improve child’s development in Arab toddlers in Israel: study protocol for a randomized controlled trial
- Whole-course care intervention for patients with spinal cord injury: study protocol for a randomized controlled trial
- Effect of an educational indoor air quality intervention on cognitive status, sleep quality, balance, and sick building syndrome in older adults: a randomized controlled trial
BibTeX
@article{keshavarz2026effects,
title = {{Effects of ginger intervention on anthropometric and body composition indices in patients with type 2 diabetes: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials.}},
author = {Ali Keshavarz and Aylee Sobhanifar and Parna Alizadeh and S Faezeh Hashemi Moghaddam and Monirsadat Mirhoseini and Fatemeh Borazjani},
journal = {BMC complementary medicine and therapies},
year = {2026},
month = aug,
doi = {10.1186/s12906-026-05492-2},
url = {https://europepmc.org/article/MED/42968062},
note = {CC BY},
}
RIS
TY - JOUR
TI - Effects of ginger intervention on anthropometric and body composition indices in patients with type 2 diabetes: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials.
AU - Ali Keshavarz
AU - Aylee Sobhanifar
AU - Parna Alizadeh
AU - S Faezeh Hashemi Moghaddam
AU - Monirsadat Mirhoseini
AU - Fatemeh Borazjani
PY - 2026
DA - 2026/08/05
JO - BMC complementary medicine and therapies
DO - 10.1186/s12906-026-05492-2
UR - https://europepmc.org/article/MED/42968062
AB - Background and aims Evidence on the effects of ginger supplementation on anthropometric and body composition indices in adults with type 2 diabetes mellitus (T2DM) is inconsistent, and the certainty of this evidence has not been fully evaluated. This study aimed to systematically review and meta-analyze randomized controlled trials assessing these effects.Methods PubMed, Scopus, and Web of Science were searched until October 5, 2025. We used random-effects meta-analysis to find average differences with 95% CIs. Study quality and evidence certainty were checked with Cochrane RoB-2 tool and GRADE approach. Subgroup, meta-regression, sensitivity, and publication bias analyses were also done.Results This meta-analysis included 692 participants from 12 RCTs. Ginger supplementation significantly reduced body mass index (BMI) (- 0.24 kg/m²; 95% CI: -0.48, - 0.00; p = 0.043) and body fat percentage (BF%) (- 1.44%; 95% CI: -2.49, - 0.38; p = 0.007), while no significant effects were observed on body weight (BW), waist circumference (WC), hip circumference (HC), or waist-to-hip ratio (WHR). Bias assessment showed 9 studies with some concerns, 1 low, and 2 high risk. Evidence quality was moderate for 4 outcomes (BMI, WHR, HC, BF%), low for WC, and high for BW.Conclusion Ginger reduced BMI and BF%, with no significant change in BW, WHR, HC, or WC.Trial registration This study was prospectively registered in PROSPERO (CRD420251162956).
SN - 2662-7671
ER -