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Peer-reviewedCC BY-NCAllergy, asthma & immunology research

Atopic Dermatitis and Sleep Disorders.

  • Genlong Bai1
  • Xinyi Shao1
  • Yi Ou1
  • Jin Chen1
  • Zhaofu Tan2
  • Aijun Chen3
  • Jingbo Zhang4
4 affiliations
  1. 1Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  2. 2Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. [email protected].
  3. 3Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. [email protected].
  4. 4Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. [email protected].
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Abstract

Purpose

Atopic dermatitis (AD) is a common inflammatory skin disease affecting 129 million people worldwide and is characterized by recurrent eczema, severe pruritus, and skin barrier damage. Previous studies on AD-sleep disorder associations were limited by small sample sizes or single-center designs, lacking large-scale epidemiological evidence. This study aimed to investigate the association between AD and sleep disorders using the UK Biobank prospective cohort and to explore effects of sex, race, and obesity on this relationship.Methods

A prospective cohort design was employed, including 329,796 participants for cross-sectional analysis and 330,875 for longitudinal analysis. Multivariable logistic regression and Cox proportional hazards models were used. Subgroup and sensitivity analyses were performed to validate robustness.Results

Cross-sectional analysis showed that AD was significantly associated with increased sleep disorder risk (adjusted odds ratio, 2.84; 95% confidence interval [CI], 2.54-3.18; P < 0.001), while the longitudinal analysis confirmed AD as an independent predictor of sleep disorders (adjusted hazard ratio, 1.51; 95% CI, 1.32-1.73; P < 0.001), with Kaplan-Meier curves further demonstrating a higher cumulative risk of sleep disorders in participants with AD. Subgroup analyses revealed stronger associations in females and participants with moderate body mass index (BMI), and sensitivity analyses validated the robustness of these findings.Conclusions

AD is an independent risk factor for sleep disorders, particularly in women and individuals with moderate BMI. Future research should further explore precision-targeted therapies and management strategies for specific populations.

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Cite

BibTeXRIS
BibTeX
@article{bai2026atopic,
  title = {{Atopic Dermatitis and Sleep Disorders.}},
  author = {Genlong Bai and Xinyi Shao and Yi Ou and Jin Chen and Zhaofu Tan and Aijun Chen and Jingbo Zhang},
  journal = {Allergy, asthma \& immunology research},
  year = {2026},
  month = sep,
  doi = {10.4168/aair.2026.18.5.751},
  url = {https://europepmc.org/article/MED/42845229},
  note = {CC BY-NC},
}
RIS
TY  - JOUR
TI  - Atopic Dermatitis and Sleep Disorders.
AU  - Genlong Bai
AU  - Xinyi Shao
AU  - Yi Ou
AU  - Jin Chen
AU  - Zhaofu Tan
AU  - Aijun Chen
AU  - Jingbo Zhang
PY  - 2026
DA  - 2026/09/01
JO  - Allergy, asthma & immunology research
DO  - 10.4168/aair.2026.18.5.751
UR  - https://europepmc.org/article/MED/42845229
AB  - Purpose  Atopic dermatitis (AD) is a common inflammatory skin disease affecting 129 million people worldwide and is characterized by recurrent eczema, severe pruritus, and skin barrier damage. Previous studies on AD-sleep disorder associations were limited by small sample sizes or single-center designs, lacking large-scale epidemiological evidence. This study aimed to investigate the association between AD and sleep disorders using the UK Biobank prospective cohort and to explore effects of sex, race, and obesity on this relationship.Methods  A prospective cohort design was employed, including 329,796 participants for cross-sectional analysis and 330,875 for longitudinal analysis. Multivariable logistic regression and Cox proportional hazards models were used. Subgroup and sensitivity analyses were performed to validate robustness.Results  Cross-sectional analysis showed that AD was significantly associated with increased sleep disorder risk (adjusted odds ratio, 2.84; 95% confidence interval [CI], 2.54-3.18; P < 0.001), while the longitudinal analysis confirmed AD as an independent predictor of sleep disorders (adjusted hazard ratio, 1.51; 95% CI, 1.32-1.73; P < 0.001), with Kaplan-Meier curves further demonstrating a higher cumulative risk of sleep disorders in participants with AD. Subgroup analyses revealed stronger associations in females and participants with moderate body mass index (BMI), and sensitivity analyses validated the robustness of these findings.Conclusions  AD is an independent risk factor for sleep disorders, particularly in women and individuals with moderate BMI. Future research should further explore precision-targeted therapies and management strategies for specific populations.
SN  - 2092-7355
SN  - 2092-7363
ER  -