Life's Essential 8, Genetic Susceptibility, and Metabolic Dysfunction-Associated Steatotic Liver Disease in Chinese Adults.
7 affiliations
- 1Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
- 2Peking University Center for Public Health and Epidemic Preparedness and Response, Beijing 100191, China.
- 3Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing, China.
- 4State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing 100191, China.
- 5Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
- 6Jili Community Health Service, Liuyang, Hunan 410300, China.
- 7China National Center for Food Safety Risk Assessment, Beijing 100022, China.
Abstract
Background: Limited evidence exists regarding the association of cardiovascular health (CVH) with metabolic dysfunction-associated steatotic liver disease (MASLD) in Chinese adults, and the influence of genetic risk on this association remains unknown. This study aimed to investigate these associations and discern potential variations based on genetic risk. Methods: This cross-sectional study included 17,077 participants from the third resurvey of the China Kadoorie Biobank. CVH was evaluated by Life's Essential 8 (LE8), with the overall score (0 to 100) calculated as the unweighted average of its 8 component scores and categorized as low (0 to 49), moderate (50 to 79), or high (80 to 100). Polygenic risk score (PRS) for MASLD was generated by meta-analytic approach and large genome-wide association data of liver steatosis and related traits. Genetic risk for MASLD was categorized into low, intermediate, and high based on quintile of metaPRS. The multivariable logistic regression model was used to evaluate the associations of CVH with MASLD and advanced fibrosis in MASLD, subsequently stratified by metaPRS. Results: High CVH was associated with over 90% lower risk of MASLD and advanced fibrosis in MASLD, with odds ratios of 0.07 (0.06 to 0.08) and 0.04 (0.02 to 0.05) compared to low CVH, respectively. Interactions of metaPRS were observed for the impacts of LE8 on both prevalent MASLD and advanced fibrosis in MASLD (P value for interaction <0.02 and <0.001, respectively), with stronger protective associations among individuals with higher genetic risk. Similar findings were observed when we tentatively expanded LE8 to Life's Crucial 9 (LC9), incorporating the psychological health component. Conclusion: In Chinese adults, adhering to a high CVH was associated with lower odds of prevalent MASLD and advanced fibrosis in MASLD, particularly among individuals at high genetic risk.
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BibTeX
@article{song2026lifes,
title = {{Life's Essential 8, Genetic Susceptibility, and Metabolic Dysfunction-Associated Steatotic Liver Disease in Chinese Adults.}},
author = {Shuyao Song and Jiaqi Liu and Ting Wu and Jun Lv and Canqing Yu and Dianjianyi Sun and Lang Pan and Pei Pei and Ling Yang and Yiping Chen and Huaidong Du and Fiona Bragg and Iona Millwood and Robin Walters and Xiaojun Li and Dan Schmidt and Maxim Barnard and Junshi Chen and Zhengming Chen and Liming Li and Yuanjie Pang and China Kadoorie Biobank Collaborative Group},
journal = {Health data science},
year = {2026},
month = oct,
doi = {10.34133/hds.0416},
url = {https://europepmc.org/article/MED/42898713},
note = {CC BY},
}
RIS
TY - JOUR
TI - Life's Essential 8, Genetic Susceptibility, and Metabolic Dysfunction-Associated Steatotic Liver Disease in Chinese Adults.
AU - Shuyao Song
AU - Jiaqi Liu
AU - Ting Wu
AU - Jun Lv
AU - Canqing Yu
AU - Dianjianyi Sun
AU - Lang Pan
AU - Pei Pei
AU - Ling Yang
AU - Yiping Chen
AU - Huaidong Du
AU - Fiona Bragg
AU - Iona Millwood
AU - Robin Walters
AU - Xiaojun Li
AU - Dan Schmidt
AU - Maxim Barnard
AU - Junshi Chen
AU - Zhengming Chen
AU - Liming Li
AU - Yuanjie Pang
AU - China Kadoorie Biobank Collaborative Group
PY - 2026
DA - 2026/10/19
JO - Health data science
DO - 10.34133/hds.0416
UR - https://europepmc.org/article/MED/42898713
AB - Background: Limited evidence exists regarding the association of cardiovascular health (CVH) with metabolic dysfunction-associated steatotic liver disease (MASLD) in Chinese adults, and the influence of genetic risk on this association remains unknown. This study aimed to investigate these associations and discern potential variations based on genetic risk. Methods: This cross-sectional study included 17,077 participants from the third resurvey of the China Kadoorie Biobank. CVH was evaluated by Life's Essential 8 (LE8), with the overall score (0 to 100) calculated as the unweighted average of its 8 component scores and categorized as low (0 to 49), moderate (50 to 79), or high (80 to 100). Polygenic risk score (PRS) for MASLD was generated by meta-analytic approach and large genome-wide association data of liver steatosis and related traits. Genetic risk for MASLD was categorized into low, intermediate, and high based on quintile of metaPRS. The multivariable logistic regression model was used to evaluate the associations of CVH with MASLD and advanced fibrosis in MASLD, subsequently stratified by metaPRS. Results: High CVH was associated with over 90% lower risk of MASLD and advanced fibrosis in MASLD, with odds ratios of 0.07 (0.06 to 0.08) and 0.04 (0.02 to 0.05) compared to low CVH, respectively. Interactions of metaPRS were observed for the impacts of LE8 on both prevalent MASLD and advanced fibrosis in MASLD (P value for interaction <0.02 and <0.001, respectively), with stronger protective associations among individuals with higher genetic risk. Similar findings were observed when we tentatively expanded LE8 to Life's Crucial 9 (LC9), incorporating the psychological health component. Conclusion: In Chinese adults, adhering to a high CVH was associated with lower odds of prevalent MASLD and advanced fibrosis in MASLD, particularly among individuals at high genetic risk.
SN - 2097-1095
SN - 2765-8783
ER -