Current understanding and future scope of nanotechnology enabled epidermal care using cosmetics and cosmeceuticals.
7 affiliations
- 1Department of Applied Chemistry, Mahatma Jyotiba Phule Rohilkhand University, Bareilly, Uttar Pradesh, India.
- 2Sonama Naturals Pvt. Ltd, Plot No 21, Sector 07, IIE Pantnagar, SIDCUL, Rudrapur, Uttarakhand, India.
- 3Department of Microbiology, College of Basic Sciences and Humanities, Chaudhary Charan Singh Haryana Agricultural University (CCS HAU), Hisar, Haryana, India.
- 4Department of Chemistry, Sanatan Dharm College (Muzaffarnagar), Maa Shakumbhari University, Saharanpur, Uttar Pradesh, India.
- 5Department of Chemistry, College of Basic Sciences and Humanities, Chaudhary Charan Singh Haryana Agricultural University (CCS HAU), Hisar, India. [email protected].
- 6Vice-Chancellor's Secretariat, Mahatma Jyotiba Phule Rohilkhand University, Bareilly, Uttar Pradesh, India. [email protected].
- 7Biophysics, College of Basic Sciences and Humanities, Govind Ballabh Pant University of Agriculture and Technology, Pantnagar, Uttarakhand, India. [email protected].
Abstract
Nanotechnology has a significant role in cosmetics and cosmeceuticals for epidermal care. In this review, mechanisms of nanomaterial penetration into the skin and penetration pathways, key physicochemical factors, as well as the various models, namely in vitro, ex vivo, and in vivo, used to investigate nanoparticle behavior with the epidermis, have been discussed. The roles of nanocarriers and active ingredients have been discussed in the design and development of nanoformulations to address limitations of conventional topical formulations, including poor solubility, instability, and limited skin penetration of active ingredients. Furthermore, they improve skin hydration, promote skin repair, and support anti-aging and antioxidant functions, influencing their effectiveness, along with safety, environmental sustainability, and global regulatory frameworks for nanomaterials in skin care products. Future research should focus on sustainable nanomaterials and advanced toxicological assessment methods to ensure consumer safety without compromising product efficacy. The details of analysis and characterization of active ingredients and nanomaterials-based formulations in epidermal care have been provided. Furthermore, the guidelines from India, the EU, and the USA are briefly provided to support stakeholders. Finally, future research directions are highlighted, with particular emphasis on integrative design strategies that combine experimental evaluation with theoretical and in silico toxicity prediction models to ensure consumer safety while maintaining product efficacy.Clinical trial number: Not applicable.
Related
- Burkitt lymphoma: current understanding, unmet needs, and research directions∗
- Beyond the scars: current understanding of risk factors, neurobiological mechanisms and effective interventions for non-suicidal self-injury in young adults.
- Current understanding of systemic inflammatory response syndrome
- White matter hyperintensities of presumed vascular origin: current understanding of development and progression
- Risk assessment of drometrizole trisiloxane as a UV filter in cosmetics
BibTeX
@article{gangwar2026current,
title = {{Current understanding and future scope of nanotechnology enabled epidermal care using cosmetics and cosmeceuticals.}},
author = {Vishesh Kumar Gangwar and Sanjesh Singh and Anuj Rana and Sarita Dhaka and Rahul Kumar Dhaka and S K Panday and Krishna Pal Singh},
journal = {Discover nano},
year = {2026},
month = oct,
doi = {10.1186/s11671-026-04945-4},
url = {https://europepmc.org/article/MED/42900312},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Current understanding and future scope of nanotechnology enabled epidermal care using cosmetics and cosmeceuticals.
AU - Vishesh Kumar Gangwar
AU - Sanjesh Singh
AU - Anuj Rana
AU - Sarita Dhaka
AU - Rahul Kumar Dhaka
AU - S K Panday
AU - Krishna Pal Singh
PY - 2026
DA - 2026/10/20
JO - Discover nano
DO - 10.1186/s11671-026-04945-4
UR - https://europepmc.org/article/MED/42900312
AB - Nanotechnology has a significant role in cosmetics and cosmeceuticals for epidermal care. In this review, mechanisms of nanomaterial penetration into the skin and penetration pathways, key physicochemical factors, as well as the various models, namely in vitro, ex vivo, and in vivo, used to investigate nanoparticle behavior with the epidermis, have been discussed. The roles of nanocarriers and active ingredients have been discussed in the design and development of nanoformulations to address limitations of conventional topical formulations, including poor solubility, instability, and limited skin penetration of active ingredients. Furthermore, they improve skin hydration, promote skin repair, and support anti-aging and antioxidant functions, influencing their effectiveness, along with safety, environmental sustainability, and global regulatory frameworks for nanomaterials in skin care products. Future research should focus on sustainable nanomaterials and advanced toxicological assessment methods to ensure consumer safety without compromising product efficacy. The details of analysis and characterization of active ingredients and nanomaterials-based formulations in epidermal care have been provided. Furthermore, the guidelines from India, the EU, and the USA are briefly provided to support stakeholders. Finally, future research directions are highlighted, with particular emphasis on integrative design strategies that combine experimental evaluation with theoretical and in silico toxicity prediction models to ensure consumer safety while maintaining product efficacy.Clinical trial number: Not applicable.
SN - 2731-9229
ER -