Histologic heterogeneity in synchronous bilateral breast cancer: a case report and literature review
- 1Department of Pathology, Shihezi University of Medicine , , ,
- 2Department of Ultrasound Medicine, The First Affiliated Hospital of Shihezi University , , ,
Abstract
Synchronous bilateral primary breast cancer (sBPBC) accounts for 2.9%–3.9% of newly diagnosed breast cancers, while cases with discordant histologic subtypes are exceptionally rare. We report on a 59-year-old woman with synchronous left-sided invasive ductal carcinoma (IDC) and right-sided invasive lobular carcinoma (ILC). The patient underwent bilateral breast-conserving surgery with sentinel lymph node biopsy, followed by adjuvant radiotherapy and endocrine therapy. No recurrence or metastasis was observed during the 12-month follow-up. To place the present case in the context of the existing literature, we comparatively reviewed seven previously reported cases of synchronous bilateral IDC and ILC. The comparison illustrated considerable heterogeneity in the clinicopathological characteristics, molecular profiles, nodal involvement, treatment strategies, and clinical outcomes. These findings support independent characterization of each breast lesion and individualized treatment planning based on the features of both tumors.
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BibTeX
@article{yuan2026histologic,
title = {{Histologic heterogeneity in synchronous bilateral breast cancer: a case report and literature review}},
author = {Xuedi Yuan and Wen Liu and Xiuxia Liu and Chuyun Sun and Yuwen Cao},
journal = {Frontiers in oncology},
year = {2026},
month = oct,
doi = {10.3389/fonc.2026.1936986},
url = {https://europepmc.org/article/PMC/PMC13668515},
note = {CC BY},
}
RIS
TY - JOUR
TI - Histologic heterogeneity in synchronous bilateral breast cancer: a case report and literature review
AU - Xuedi Yuan
AU - Wen Liu
AU - Xiuxia Liu
AU - Chuyun Sun
AU - Yuwen Cao
PY - 2026
DA - 2026/10/01
JO - Frontiers in oncology
DO - 10.3389/fonc.2026.1936986
UR - https://europepmc.org/article/PMC/PMC13668515
AB - Synchronous bilateral primary breast cancer (sBPBC) accounts for 2.9%–3.9% of newly diagnosed breast cancers, while cases with discordant histologic subtypes are exceptionally rare. We report on a 59-year-old woman with synchronous left-sided invasive ductal carcinoma (IDC) and right-sided invasive lobular carcinoma (ILC). The patient underwent bilateral breast-conserving surgery with sentinel lymph node biopsy, followed by adjuvant radiotherapy and endocrine therapy. No recurrence or metastasis was observed during the 12-month follow-up. To place the present case in the context of the existing literature, we comparatively reviewed seven previously reported cases of synchronous bilateral IDC and ILC. The comparison illustrated considerable heterogeneity in the clinicopathological characteristics, molecular profiles, nodal involvement, treatment strategies, and clinical outcomes. These findings support independent characterization of each breast lesion and individualized treatment planning based on the features of both tumors.
SN - 2234-943X
ER -