Human papillomavirus infection and risk of cardiovascular disease: A population-based matched cohort study with sibling analysis
6 affiliations
- 1Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
- 2Clinical Research Unit, Shanghai Disabled Persons’ Federation Key Laboratory of Intelligent Rehabilitation Assistive Devices and Technologies, Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), Tongji University School of Medicine, Shanghai, China
- 3Laboratory of Mental Health Research, Tongji University School of Medicine, Shanghai, China
- 4Department of Paediatrics, Örebro University Hospital, Örebro, Sweden
- 5Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, United States of America
- 6Institute for Advanced Study, Tongji University, Shanghai, China
Abstract
Background: The role of human papillomavirus (HPV) in cardiovascular disease (CVD) remains unclear. We aimed to investigate the associations of HPV infection with incident CVD and CVD-related mortality. Methods and findings: In this population-based matched cohort study based on Swedish national registers, we identified women with an incident HPV infection during 2006 and 2024 (N = 497,445), and age-matched each woman with five women without infection. The time-varying associations between HPV infection and CVD were assessed using flexible parametric models, which also provided hazard ratios (HRs) and 95% confidence intervals (CIs) after adjusting for sociodemographic factors, HPV vaccination, chronic diseases, and parental history of related diseases. To control for familial factors, we also compared 143,787 women with HPV infection to their 174,637 unaffected full siblings. Conclusions: HPV infection was associated with increased risk of incident CVD and CVD-related mortality. The findings suggested that clinicians should be aware of a slightly elevated CVD risk in women with HPV, especially during the first year following an infection. However, given the small absolute difference, women should not be unduly concerned. Why was this study done?: What did the researchers do and find?: What do these findings mean?: In a large Swedish population study, Yunyang Deng and colleagues found that women with human papillomavirus (HPV) infection had slightly higher rates of cardiovascular disease and cardiovascular-related mortality than those without HPV, with the strongest associations observed during the first year after infection.
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BibTeX
@article{deng2026human,
title = {{Human papillomavirus infection and risk of cardiovascular disease: A population-based matched cohort study with sibling analysis}},
author = {Yunyang Deng and Mark Clements and Chaonan Shen and Jonas F. Ludvigsson and Qing Shen and Jiayao Lei},
journal = {PLOS Medicine},
year = {2026},
month = sep,
doi = {10.1371/journal.pmed.1005222},
url = {https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1005222},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Human papillomavirus infection and risk of cardiovascular disease: A population-based matched cohort study with sibling analysis
AU - Yunyang Deng
AU - Mark Clements
AU - Chaonan Shen
AU - Jonas F. Ludvigsson
AU - Qing Shen
AU - Jiayao Lei
PY - 2026
DA - 2026/09/01
JO - PLOS Medicine
DO - 10.1371/journal.pmed.1005222
UR - https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1005222
AB - Background: The role of human papillomavirus (HPV) in cardiovascular disease (CVD) remains unclear. We aimed to investigate the associations of HPV infection with incident CVD and CVD-related mortality. Methods and findings: In this population-based matched cohort study based on Swedish national registers, we identified women with an incident HPV infection during 2006 and 2024 (N = 497,445), and age-matched each woman with five women without infection. The time-varying associations between HPV infection and CVD were assessed using flexible parametric models, which also provided hazard ratios (HRs) and 95% confidence intervals (CIs) after adjusting for sociodemographic factors, HPV vaccination, chronic diseases, and parental history of related diseases. To control for familial factors, we also compared 143,787 women with HPV infection to their 174,637 unaffected full siblings. Conclusions: HPV infection was associated with increased risk of incident CVD and CVD-related mortality. The findings suggested that clinicians should be aware of a slightly elevated CVD risk in women with HPV, especially during the first year following an infection. However, given the small absolute difference, women should not be unduly concerned. Why was this study done?: What did the researchers do and find?: What do these findings mean?: In a large Swedish population study, Yunyang Deng and colleagues found that women with human papillomavirus (HPV) infection had slightly higher rates of cardiovascular disease and cardiovascular-related mortality than those without HPV, with the strongest associations observed during the first year after infection.
SN - 1549-1676
ER -