Polychondritis and Arthritis in a Patient with Coexisting Alkaptonuria and Psoriasis Vulgaris

Abstract

Alkaptonuria is an organic acid metabolic disorder caused by abnormalities of the tyrosine metabolic pathway. Herein, we report a case of relapsing polychondritis and arthritis in a patient with alkaptonuria and psoriasis vulgaris, respectively. A 53-year-old man, previously diagnosed with alkaptonuria and psoriasis vulgaris, was found to have auricular thickening and tenderness, bilateral bulbar conjunctival injection, and elevated C-reactive protein levels. Ultrasound imaging revealed enthesitis in the bilateral knee joints. A biopsy of the auricular cartilage revealed lymphocytic infiltration. The coexistence of ocular involvement, auricular chondritis, and enthesitis was considered indicative of alkaptonuria complicated by relapsing polychondritis and psoriatic arthritis.

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BibTeX

@article{shono2026polychondritis,
  title = {{Polychondritis and Arthritis in a Patient with Coexisting Alkaptonuria and Psoriasis Vulgaris}},
  author = {Kensei Shono and Eiko Kawakami and Serina Koto and Shoichi Fukui and Takashi Jubashi and Kanako Kojima and Toshimasa Shimizu and Hirofumi Koike and Nozomi Ueki and Atsushi Kawakami},
  journal = {Internal Medicine},
  year = {2026},
  month = aug,
  doi = {10.2169/internalmedicine.6575-25},
  url = {https://www.jstage.jst.go.jp/article/internalmedicine/65/15/65_6575-25/_article},
  note = {CC BY-NC-ND},
}

RIS

TY  - JOUR
TI  - Polychondritis and Arthritis in a Patient with Coexisting Alkaptonuria and Psoriasis Vulgaris
AU  - Kensei Shono
AU  - Eiko Kawakami
AU  - Serina Koto
AU  - Shoichi Fukui
AU  - Takashi Jubashi
AU  - Kanako Kojima
AU  - Toshimasa Shimizu
AU  - Hirofumi Koike
AU  - Nozomi Ueki
AU  - Atsushi Kawakami
PY  - 2026
DA  - 2026/08/01
JO  - Internal Medicine
DO  - 10.2169/internalmedicine.6575-25
UR  - https://www.jstage.jst.go.jp/article/internalmedicine/65/15/65_6575-25/_article
AB  - Alkaptonuria is an organic acid metabolic disorder caused by abnormalities of the tyrosine metabolic pathway. Herein, we report a case of relapsing polychondritis and arthritis in a patient with alkaptonuria and psoriasis vulgaris, respectively. A 53-year-old man, previously diagnosed with alkaptonuria and psoriasis vulgaris, was found to have auricular thickening and tenderness, bilateral bulbar conjunctival injection, and elevated C-reactive protein levels. Ultrasound imaging revealed enthesitis in the bilateral knee joints. A biopsy of the auricular cartilage revealed lymphocytic infiltration. The coexistence of ocular involvement, auricular chondritis, and enthesitis was considered indicative of alkaptonuria complicated by relapsing polychondritis and psoriatic arthritis.
SN  - 1349-7235
SN  - 0918-2918
ER  -

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