Skip to content
DraconiticResearch
Search Sources API
201,818 studies31 sourcesUpdated 10 min ago
Peer-reviewedCC BYACS omega

A pH-Dependent Curcumin–Iminosugar Hybrid Promotes GCase Enhancement and Reactive Oxygen Species Reduction

  • Alessio Morano1
  • Camilla Matassini1
  • Francesca Cardona1
  • Damiano Tanini1
  • Silvia Falliano2
  • Amelia Morrone2,3
  • Rebecca Sodano4
  • Paolo Paoli4
  • Andrea Goti1
  • Francesca Clemente1
4 affiliations
  1. 1University of Florence , , Via della Lastruccia 3−13 , ,
  2. 2Meyer Children’s Hospital IRCCS , , Viale Pieraccini 24 , ,
  3. 3University of Florence , , Viale Pieraccini 24 , ,
  4. 4University of Florence , , Viale Morgagni 50 ,
Read full textPDFDOICite

Abstract

Gaucher disease and Parkinson’s disease are characterized by β-glucocerebrosidase (GCase) dysfunction and increased oxidative stress. Here, we report two multifunctional hybrids that combine an iminosugar-based pharmacological chaperone scaffold with curcumin- or ferulic acid-derived antioxidant motifs. The curcumin-iminosugar hybrid 2 exhibits pH-dependent GCase modulation, enhanced GCase activity under lysosomal conditions, enhanced enzyme activity in L444P Gaucher and wild-type fibroblasts, and reduced intracellular reactive oxygen species (ROS) levels. By integrating GCase enhancement and redox modulation within a single molecular framework, compound 2 represents a promising lead for Gaucher disease and GCase-related synucleinopathies.

Related

  1. In situ-forming manganese-curcumin nanozyme film promotes diabetic wound healing via photothermal antibacterial and anti-inflammatory actions
    Yuxin Wang, Long Wang, Weifeng Yang +6
    Materials today. BioPeer-reviewedCC BYFull textGeneral medicineEurope PMCEurope PMCPMC
  2. Beyond DNA Demethylation: Curcumin as a Context-Dependent Remodeler of the Epigenetic Landscape
    Salvatore Costa, Maria Antonietta Ragusa, Aldo Nicosia
    International Journal of Molecular SciencesPeer-reviewedCC BY 4.0General medicineCrossref
  3. NDUFS1 promotes malignant breast cancer behaviors through enhancement of mitochondrial respiration and PROX1/c-Myc signaling
    Yen-Yun Wang, Pang-Yu Chen, Lester Uy Vinzons +8
    iSciencePeer-reviewedCC BY 4.0Full textOncologyCell PressCrossrefPMCEurope PMC
  4. Motor Module-Guided Human-Machine Interaction Promotes Improvement of Neuromuscular Coordination and Reduction in Motor Impairment in Chronic Stroke: A Pilot Study
    M. A. Portilla-Jimenez, G. Seo, Y. N. G. Hong +6
    medRxivPreprintAll rights reservedFull textGeneral medicinemedRxiv
  5. Cysteine reduction rather than methionine restriction promotes immunometabolic fitness to confer survival benefit in aging
    L. Orliaguet, H.-H. Kim, P. Gupta +12
    bioRxivPreprintCC BY-NC-NDFull textPhysiologybioRxiv

Cite

BibTeXRIS
BibTeX
@article{morano2026phdependent,
  title = {{A pH-Dependent Curcumin–Iminosugar Hybrid Promotes GCase Enhancement and Reactive Oxygen Species Reduction}},
  author = {Alessio Morano and Camilla Matassini and Francesca Cardona and Damiano Tanini and Silvia Falliano and Amelia Morrone and Rebecca Sodano and Paolo Paoli and Andrea Goti and Francesca Clemente},
  journal = {ACS omega},
  year = {2026},
  month = oct,
  doi = {10.1021/acsomega.6c08401},
  url = {https://europepmc.org/article/PMC/PMC13670301},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - A pH-Dependent Curcumin–Iminosugar Hybrid Promotes GCase Enhancement and Reactive Oxygen Species Reduction
AU  - Alessio Morano
AU  - Camilla Matassini
AU  - Francesca Cardona
AU  - Damiano Tanini
AU  - Silvia Falliano
AU  - Amelia Morrone
AU  - Rebecca Sodano
AU  - Paolo Paoli
AU  - Andrea Goti
AU  - Francesca Clemente
PY  - 2026
DA  - 2026/10/01
JO  - ACS omega
DO  - 10.1021/acsomega.6c08401
UR  - https://europepmc.org/article/PMC/PMC13670301
AB  - Gaucher disease and Parkinson’s disease are characterized by β-glucocerebrosidase (GCase) dysfunction and increased oxidative stress. Here, we report two multifunctional hybrids that combine an iminosugar-based pharmacological chaperone scaffold with curcumin- or ferulic acid-derived antioxidant motifs. The curcumin-iminosugar hybrid 2 exhibits pH-dependent GCase modulation, enhanced GCase activity under lysosomal conditions, enhanced enzyme activity in L444P Gaucher and wild-type fibroblasts, and reduced intracellular reactive oxygen species (ROS) levels. By integrating GCase enhancement and redox modulation within a single molecular framework, compound 2 represents a promising lead for Gaucher disease and GCase-related synucleinopathies.
SN  - 2470-1343
ER  -