In situ-forming manganese-curcumin nanozyme film promotes diabetic wound healing via photothermal antibacterial and anti-inflammatory actions
- 1State Key Laboratory of Advanced Technology for Material Synthesis and Processing, Wuhan University of Technology, Wuhan, 430070, China
- 2Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing, 100700, China
Abstract
Oxidative stress, bacterial infection, and persistent inflammatory responses are key inhibitory factors for chronic wound healing, yet most conventional dressings fail to simultaneously address these pathological barriers. This study presents a multifunctional composite film incorporating manganese-curcumin (Mn-Cur) nanozymes prepared via a facile, carrier-free synthesis. These nanozymes exhibit dual superoxide dismutase (SOD)- and catalase (CAT)-mimetic activities, enabling efficient elimination of superoxide anion radicals (•O₂ ⁻) and hydrogen peroxide (H₂O₂). A rapid Prussian blue (PB) coating is introduced onto the Mn-Cur surface to enhance biocompatibility and confer photothermal antibacterial capability, forming Mn-Cur@PB (MC@PB) nanocomposites. The engineered nanozymes efficiently scavenge excess reactive oxygen species (ROS), exert potent antibacterial activity, and attenuate pro-inflammatory macrophage activation while inducing an immunoregulatory phenotype. The MC@PB nanocomposites are subsequently incorporated into a silk fibroin (SF)/polyvinyl butyral (PVB) matrix and cast into an in situ-forming wound dressing (denoted SPMP), bridging nanomaterial design and practical wound management. In vivo evaluation using infected diabetic wound models confirms that, under near-infrared (NIR) irradiation, the SPMP dressing effectively eliminates bacteria, alleviates inflammation, facilitates collagen deposition and angiogenesis, and accelerates wound closure. This multifunctional SPMP film represents a promising candidate for clinical chronic wound treatment.
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BibTeX
@article{wang2026situforming,
title = {{In situ-forming manganese-curcumin nanozyme film promotes diabetic wound healing via photothermal antibacterial and anti-inflammatory actions}},
author = {Yuxin Wang and Long Wang and Weifeng Yang and Bingjie Sun and Xinyao Huang and Xiaohong Wang and Meiyu Zhang and Xinyu Wang and Jing Tu},
journal = {Materials today. Bio},
year = {2026},
month = oct,
doi = {10.1016/j.mtbio.2026.103759},
url = {https://europepmc.org/article/PMC/PMC13717171},
note = {CC BY},
}
RIS
TY - JOUR
TI - In situ-forming manganese-curcumin nanozyme film promotes diabetic wound healing via photothermal antibacterial and anti-inflammatory actions
AU - Yuxin Wang
AU - Long Wang
AU - Weifeng Yang
AU - Bingjie Sun
AU - Xinyao Huang
AU - Xiaohong Wang
AU - Meiyu Zhang
AU - Xinyu Wang
AU - Jing Tu
PY - 2026
DA - 2026/10/19
JO - Materials today. Bio
DO - 10.1016/j.mtbio.2026.103759
UR - https://europepmc.org/article/PMC/PMC13717171
AB - Oxidative stress, bacterial infection, and persistent inflammatory responses are key inhibitory factors for chronic wound healing, yet most conventional dressings fail to simultaneously address these pathological barriers. This study presents a multifunctional composite film incorporating manganese-curcumin (Mn-Cur) nanozymes prepared via a facile, carrier-free synthesis. These nanozymes exhibit dual superoxide dismutase (SOD)- and catalase (CAT)-mimetic activities, enabling efficient elimination of superoxide anion radicals (•O₂ ⁻) and hydrogen peroxide (H₂O₂). A rapid Prussian blue (PB) coating is introduced onto the Mn-Cur surface to enhance biocompatibility and confer photothermal antibacterial capability, forming Mn-Cur@PB (MC@PB) nanocomposites. The engineered nanozymes efficiently scavenge excess reactive oxygen species (ROS), exert potent antibacterial activity, and attenuate pro-inflammatory macrophage activation while inducing an immunoregulatory phenotype. The MC@PB nanocomposites are subsequently incorporated into a silk fibroin (SF)/polyvinyl butyral (PVB) matrix and cast into an in situ-forming wound dressing (denoted SPMP), bridging nanomaterial design and practical wound management. In vivo evaluation using infected diabetic wound models confirms that, under near-infrared (NIR) irradiation, the SPMP dressing effectively eliminates bacteria, alleviates inflammation, facilitates collagen deposition and angiogenesis, and accelerates wound closure. This multifunctional SPMP film represents a promising candidate for clinical chronic wound treatment.
SN - 2590-0064
ER -