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Peer-reviewedCC BY-NC-NDIntegrative Zoology

Amphibian‐Derived Peptide OA‐AL14 Alleviates UVB‐Induced Skin Photoaging via Autophagy Activation Mediated by the AMPK/mTOR Pathway

  • Ying Peng1
  • Yu Wu1
  • Zhe Fu1
  • Zijian Kang1
  • Qiuye Jia1
  • Wenbi Zhao1
  • Z P Wang1
  • Yuexi Liu1
  • Ruijie Zhang1
  • Y F Li2,1
  • Zeqiong Ru1
  • Wenrou Su3
5 more authors
  • Naixin Liu1
  • Yilin Li2,1
  • Saige Yin1
  • Ying Wang4
  • Xinwang Yang1,3
4 affiliations
  1. 1Key Laboratory of Skin and Mucosal Injury Repair, Regeneration & Active Peptides of Yunnan Provincial Department of Education, Regenerative Medicine Research Center, Faculty of Basic Medical Science Kunming Medical University Kunming Yunnan China
  2. 2Department of Pharmacology, Faculty of Basic Medical Science Kunming Medical University Kunming Yunnan China
  3. 3Yunnan Characteristic Plant Extraction Laboratory Co., Ltd. Yunnan China
  4. 4Key Laboratory of Chemistry in Ethnic Medicinal Resources & Key Laboratory of Natural Products Synthetic Biology of Ethnic Medicinal Endophytes, State Ethnic Affairs Commission & Ministry of Education, School of Ethnic Medicine Yunnan Minzu University Kunming Yunnan China
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Abstract

Skin photoaging, primarily driven by ultraviolet B (UVB) radiation, is a complex process involving oxidative stress and autophagic dysfunction, for which effective therapeutic options remain limited. Here, we identified a novel peptide, OA-AL14 (ALFWPMKKPWPESC), from the skin secretions of the frog Odorrana andersonii Boulenger, 1882, and investigated its protective effects against UVB-induced photoaging. OA-AL14 exhibited excellent biocompatibility and potent antioxidant activity in vitro. In a UVB-irradiated mouse model, topical application of OA-AL14 significantly ameliorated key features of photoaging, including erythema, pigmentation, epidermal hyperplasia, and barrier disruption. Mechanistically, OA-AL14 activated the Nrf2 antioxidant pathway and restored cellular redox balance. Furthermore, transcriptomic and biochemical analyses revealed that OA-AL14 induced protective autophagy via the AMPK/mTOR signaling pathway. Inhibition of autophagy partially abrogated its protective effects, confirming the functional relevance of this mechanism. These findings establish OA-AL14 as a promising multifunctional candidate for treating skin photoaging by integrating antioxidant defense and autophagy activation.

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Cite

BibTeXRIS
BibTeX
@article{peng2026amphibianderived,
  title = {{Amphibian‐Derived Peptide OA‐AL14 Alleviates UVB‐Induced Skin Photoaging via Autophagy Activation Mediated by the AMPK/mTOR Pathway}},
  author = {Ying Peng and Yu Wu and Zhe Fu and Zijian Kang and Qiuye Jia and Wenbi Zhao and Z P Wang and Yuexi Liu and Ruijie Zhang and Y F Li and Zeqiong Ru and Wenrou Su and Naixin Liu and Yilin Li and Saige Yin and Ying Wang and Xinwang Yang},
  journal = {Integrative Zoology},
  year = {2026},
  month = jun,
  doi = {10.1111/1749-4877.70134},
  url = {https://doi.org/10.1111/1749-4877.70134},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Amphibian‐Derived Peptide OA‐AL14 Alleviates UVB‐Induced Skin Photoaging via Autophagy Activation Mediated by the AMPK/mTOR Pathway
AU  - Ying Peng
AU  - Yu Wu
AU  - Zhe Fu
AU  - Zijian Kang
AU  - Qiuye Jia
AU  - Wenbi Zhao
AU  - Z P Wang
AU  - Yuexi Liu
AU  - Ruijie Zhang
AU  - Y F Li
AU  - Zeqiong Ru
AU  - Wenrou Su
AU  - Naixin Liu
AU  - Yilin Li
AU  - Saige Yin
AU  - Ying Wang
AU  - Xinwang Yang
PY  - 2026
DA  - 2026/06/04
JO  - Integrative Zoology
DO  - 10.1111/1749-4877.70134
UR  - https://doi.org/10.1111/1749-4877.70134
AB  - Skin photoaging, primarily driven by ultraviolet B (UVB) radiation, is a complex process involving oxidative stress and autophagic dysfunction, for which effective therapeutic options remain limited. Here, we identified a novel peptide, OA-AL14 (ALFWPMKKPWPESC), from the skin secretions of the frog Odorrana andersonii Boulenger, 1882, and investigated its protective effects against UVB-induced photoaging. OA-AL14 exhibited excellent biocompatibility and potent antioxidant activity in vitro. In a UVB-irradiated mouse model, topical application of OA-AL14 significantly ameliorated key features of photoaging, including erythema, pigmentation, epidermal hyperplasia, and barrier disruption. Mechanistically, OA-AL14 activated the Nrf2 antioxidant pathway and restored cellular redox balance. Furthermore, transcriptomic and biochemical analyses revealed that OA-AL14 induced protective autophagy via the AMPK/mTOR signaling pathway. Inhibition of autophagy partially abrogated its protective effects, confirming the functional relevance of this mechanism. These findings establish OA-AL14 as a promising multifunctional candidate for treating skin photoaging by integrating antioxidant defense and autophagy activation.
SN  - 1749-4868
SN  - 1749-4869
SN  - 1749-4877
ER  -