One-Year Outcomes of Green Laser Endoscopic Cyclophotocoagulation and Factors Associated with Surgical Failure: A Retrospective Observational Study.
- 1Department of Ophthalmology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan.
- 2Department of Ophthalmology, The University of Tokyo Hospital, Tokyo, Japan.
Abstract
Purpose
We evaluated the 1-year outcomes of green laser endoscopic cyclophotocoagulation (ECP), a newly developed procedure approved in Japan.Patients and methods
We retrospectively analyzed 29 eyes of 26 patients who underwent green laser ECP. Intraocular pressure (IOP), glaucoma medication burden, and laser flare were evaluated preoperatively and at 1, 3, 6, 9, and 12 months postoperatively. Kaplan-Meier survival analysis was used to estimate the 12-month success rate. Surgical success was defined as meeting all of the following criteria: IOP ≤21 mmHg, a ≥20% reduction from baseline, and no additional glaucoma surgery. Univariate and multivariable Cox proportional hazards analyses were performed to evaluate factors associated with surgical failure.Results
The mean IOP decreased from 23.4 ± 8.5 mmHg preoperatively to 17.4 ± 6.9, 16.9 ± 5.2, and 17.5 ± 7.3 mmHg at 1, 3, and 6 months postoperatively, respectively, with significant reductions maintained through 6 months (p < 0.01). However, IOP increased to 21.1 ± 7.9 and 22.3 ± 11.8 mmHg at 9 and 12 months, respectively, with no significant differences from baseline. The glaucoma medication score decreased significantly through 3 months postoperatively (p = 0.02) but returned to baseline levels thereafter. Laser flare increased significantly through 1 month postoperatively (p < 0.01) and decreased numerically through 3 months. The 12-month estimated success rate was 0.36. In multivariable Cox analysis, higher preoperative IOP was significantly associated with a greater risk of surgical failure (HR, 1.10; 95% CI, 1.05-1.15; p < 0.001), whereas age and postoperative laser flare were not significantly associated with failure.Conclusion
Green laser ECP significantly lowered IOP through 6 months postoperatively; however, the estimated 12-month surgical success rate was 36%. Optimization of laser parameters and treatment strategies may be needed to improve long-term outcomes.
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BibTeX
@article{takahashi2026oneyear,
title = {{One-Year Outcomes of Green Laser Endoscopic Cyclophotocoagulation and Factors Associated with Surgical Failure: A Retrospective Observational Study.}},
author = {Yoshiaki Takahashi and Shun Nakayama and Akira Imai and Junya Kitahara and Shinji Kakihara and Takao Hirano and Toshinori Murata},
journal = {Clinical ophthalmology (Auckland, N.Z.)},
year = {2026},
month = oct,
doi = {10.2147/opth.s625216},
url = {https://europepmc.org/article/MED/42898636},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - One-Year Outcomes of Green Laser Endoscopic Cyclophotocoagulation and Factors Associated with Surgical Failure: A Retrospective Observational Study.
AU - Yoshiaki Takahashi
AU - Shun Nakayama
AU - Akira Imai
AU - Junya Kitahara
AU - Shinji Kakihara
AU - Takao Hirano
AU - Toshinori Murata
PY - 2026
DA - 2026/10/14
JO - Clinical ophthalmology (Auckland, N.Z.)
DO - 10.2147/opth.s625216
UR - https://europepmc.org/article/MED/42898636
AB - Purpose We evaluated the 1-year outcomes of green laser endoscopic cyclophotocoagulation (ECP), a newly developed procedure approved in Japan.Patients and methods We retrospectively analyzed 29 eyes of 26 patients who underwent green laser ECP. Intraocular pressure (IOP), glaucoma medication burden, and laser flare were evaluated preoperatively and at 1, 3, 6, 9, and 12 months postoperatively. Kaplan-Meier survival analysis was used to estimate the 12-month success rate. Surgical success was defined as meeting all of the following criteria: IOP ≤21 mmHg, a ≥20% reduction from baseline, and no additional glaucoma surgery. Univariate and multivariable Cox proportional hazards analyses were performed to evaluate factors associated with surgical failure.Results The mean IOP decreased from 23.4 ± 8.5 mmHg preoperatively to 17.4 ± 6.9, 16.9 ± 5.2, and 17.5 ± 7.3 mmHg at 1, 3, and 6 months postoperatively, respectively, with significant reductions maintained through 6 months (p < 0.01). However, IOP increased to 21.1 ± 7.9 and 22.3 ± 11.8 mmHg at 9 and 12 months, respectively, with no significant differences from baseline. The glaucoma medication score decreased significantly through 3 months postoperatively (p = 0.02) but returned to baseline levels thereafter. Laser flare increased significantly through 1 month postoperatively (p < 0.01) and decreased numerically through 3 months. The 12-month estimated success rate was 0.36. In multivariable Cox analysis, higher preoperative IOP was significantly associated with a greater risk of surgical failure (HR, 1.10; 95% CI, 1.05-1.15; p < 0.001), whereas age and postoperative laser flare were not significantly associated with failure.Conclusion Green laser ECP significantly lowered IOP through 6 months postoperatively; however, the estimated 12-month surgical success rate was 36%. Optimization of laser parameters and treatment strategies may be needed to improve long-term outcomes.
SN - 1177-5467
SN - 1177-5483
ER -