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Peer-reviewedCC BY-NCJournal for immunotherapy of cancer

Distinct genomic landscapes of mismatch-repair deficiency (dMMR)/microsatellite instability-high (MSI-H) gastrointestinal (GI) cancer depending on tumor mutation burden (TMB) levels.

  • Jingyuan Wang1,2,3
  • Joanne Xiu4
  • Alex P Farrell4
  • Francesca Battaglin2
  • Hiroyuki Arai2
  • Yan Yang5
  • Shivani Soni2
  • Wu Zhang2
  • Joshua Millstein5
  • Anthony F Shields6
  • Axel Grothey7
  • Benjamin A Weinberg8
9 more authors
  • John Marshall8
  • Emil Lou9
  • Moh'd Khushman10
  • Davendra P S Sohal11
  • Michael J Hall12
  • Tianshu Liu1,3
  • Matthew James Oberley4
  • David Spetzler4
  • Heinz-Josef Lenz13
13 affiliations
  1. 1Department of Medical Oncology, Cancer Center, Zhongshan Hospital Fudan University, Shanghai, China.
  2. 2Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
  3. 3Department of Oncology, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, China. Clinical Research Center for Precision Medicine of Abdominal Tumor of Fujian Province, Xiamen, Fujian.
  4. 4Caris Life Sciences, Phoenix, Arizona, USA.
  5. 5Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
  6. 6Department of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, USA.
  7. 7Gastrointestinal Cancer Research, West Cancer Center and Research Institute, Germantown, Tennessee, USA.
  8. 8Ruesch Center for The Cure of Gastrointestinal Cancers, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, District of Columbia, USA.
  9. 9Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, Minnesota, USA.
  10. 10Departments of Medical Oncology, Washington University in St. Louis/Siteman Cancer Center, St. Louis, Missouri, USA.
  11. 11University of Cincinnati, Cincinnati, Ohio, USA.
  12. 12Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.
  13. 13Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA [email protected].
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Cite

BibTeXRIS
BibTeX
@article{wang2026distinct,
  title = {{Distinct genomic landscapes of mismatch-repair deficiency (dMMR)/microsatellite instability-high (MSI-H) gastrointestinal (GI) cancer depending on tumor mutation burden (TMB) levels.}},
  author = {Jingyuan Wang and Joanne Xiu and Alex P Farrell and Francesca Battaglin and Hiroyuki Arai and Yan Yang and Shivani Soni and Wu Zhang and Joshua Millstein and Anthony F Shields and Axel Grothey and Benjamin A Weinberg and John Marshall and Emil Lou and Moh'd Khushman and Davendra P S Sohal and Michael J Hall and Tianshu Liu and Matthew James Oberley and David Spetzler and Heinz-Josef Lenz},
  journal = {Journal for immunotherapy of cancer},
  year = {2026},
  month = oct,
  doi = {10.1136/jitc-2026-015933},
  url = {https://europepmc.org/article/MED/42880820},
  note = {CC BY-NC},
}
RIS
TY  - JOUR
TI  - Distinct genomic landscapes of mismatch-repair deficiency (dMMR)/microsatellite instability-high (MSI-H) gastrointestinal (GI) cancer depending on tumor mutation burden (TMB) levels.
AU  - Jingyuan Wang
AU  - Joanne Xiu
AU  - Alex P Farrell
AU  - Francesca Battaglin
AU  - Hiroyuki Arai
AU  - Yan Yang
AU  - Shivani Soni
AU  - Wu Zhang
AU  - Joshua Millstein
AU  - Anthony F Shields
AU  - Axel Grothey
AU  - Benjamin A Weinberg
AU  - John Marshall
AU  - Emil Lou
AU  - Moh'd Khushman
AU  - Davendra P S Sohal
AU  - Michael J Hall
AU  - Tianshu Liu
AU  - Matthew James Oberley
AU  - David Spetzler
AU  - Heinz-Josef Lenz
PY  - 2026
DA  - 2026/10/15
JO  - Journal for immunotherapy of cancer
DO  - 10.1136/jitc-2026-015933
UR  - https://europepmc.org/article/MED/42880820
SN  - 2051-1426
ER  -