Epidemiology, microbiological characteristics, and antimicrobial resistance of device-associated healthcare-associated infections in a neonatal intensive care unit: a six-year surveillance study
Abstract
BackgroundDevice-associated healthcare-associated infections (DA-HAIs) remain an important concern in neonatal intensive care units (NICUs). This study describes six-year surveillance data on the epidemiology, device utilization, pathogen distribution, and antimicrobial resistance of DA-HAIs.MethodsWe conducted a retrospective descriptive surveillance study from 2020 to 2025. Ventilator-associated pneumonia (VAP), central line-associated bloodstream infection (CLABSI), and catheter-associated urinary tract infection (CAUTI) were classified using a standardized CDC/NHSN surveillance framework. Annual infection rates per 1,000 device-days, exact 95% confidence intervals (CIs), device utilization ratios, and isolate-level microbiological data were summarized.ResultsTwenty-four CLABSI episodes occurred during 17,033 central-line days (1.41 per 1,000 line-days; 95% CI, 0.90–2.10), and 46 VAP episodes occurred during 21,628 ventilator-days (2.13 per 1,000 ventilator-days; 95% CI, 1.56–2.84). No CAUTI episodes occurred during 2,294 urinary catheter-days (95% CI, 0.00–1.61 per 1,000 catheter-days). Coagulase-negative staphylococci predominated among CLABSI isolates. Gram-negative organisms accounted for 25 of 42 recorded VAP isolates, while Staphylococcus haemolyticus was the single most common VAP isolate. MDR classifications varied by organism.ConclusionThese surveillance data characterize local DA-HAI patterns and support continued attention to device stewardship, microbiological surveillance, and antimicrobial stewardship.
Related
- Bloodstream Infections in Patients with Malignancy: Microbiological Epidemiology, Antimicrobial Resistance, and Factors Associated with Mortality in a Nine-Year Single-Center Retrospective Cohort
- Epidemiology and Antimicrobial Resistance of Klebsiella pneumoniae at a Tertiary Oncology Centre in Astana, Kazakhstan, 2022-2026: A Prospective Longitudinal Surveillance Study
- From Host Response to Microbiological Risk: Association of the RIN-IM Score with Culture-Positive Sepsis and Antimicrobial Resistance in Critically Ill Adults
- Microbiological information in the precipitate and supernatant fractions after wastewater centrifugation—loss or profit for hygiene, epidemiology, and environmental surveillance?
- Microbiological profile and antimicrobial resistance of surgical wound infections in a tertiary hospital in Azerbaijan.
BibTeX
@article{zhang2026epidemiology,
title = {{Epidemiology, microbiological characteristics, and antimicrobial resistance of device-associated healthcare-associated infections in a neonatal intensive care unit: a six-year surveillance study}},
author = {Haiqiao Zhang and Mingyan Zou and Xiaoming Guo and Jiayu Cai and Zidong Liang},
journal = {Frontiers in Public Health},
year = {2026},
month = oct,
doi = {10.3389/fpubh.2026.1979471},
url = {https://www.frontiersin.org/articles/10.3389/fpubh.2026.1979471},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Epidemiology, microbiological characteristics, and antimicrobial resistance of device-associated healthcare-associated infections in a neonatal intensive care unit: a six-year surveillance study
AU - Haiqiao Zhang
AU - Mingyan Zou
AU - Xiaoming Guo
AU - Jiayu Cai
AU - Zidong Liang
PY - 2026
DA - 2026/10/30
JO - Frontiers in Public Health
DO - 10.3389/fpubh.2026.1979471
UR - https://www.frontiersin.org/articles/10.3389/fpubh.2026.1979471
AB - BackgroundDevice-associated healthcare-associated infections (DA-HAIs) remain an important concern in neonatal intensive care units (NICUs). This study describes six-year surveillance data on the epidemiology, device utilization, pathogen distribution, and antimicrobial resistance of DA-HAIs.MethodsWe conducted a retrospective descriptive surveillance study from 2020 to 2025. Ventilator-associated pneumonia (VAP), central line-associated bloodstream infection (CLABSI), and catheter-associated urinary tract infection (CAUTI) were classified using a standardized CDC/NHSN surveillance framework. Annual infection rates per 1,000 device-days, exact 95% confidence intervals (CIs), device utilization ratios, and isolate-level microbiological data were summarized.ResultsTwenty-four CLABSI episodes occurred during 17,033 central-line days (1.41 per 1,000 line-days; 95% CI, 0.90–2.10), and 46 VAP episodes occurred during 21,628 ventilator-days (2.13 per 1,000 ventilator-days; 95% CI, 1.56–2.84). No CAUTI episodes occurred during 2,294 urinary catheter-days (95% CI, 0.00–1.61 per 1,000 catheter-days). Coagulase-negative staphylococci predominated among CLABSI isolates. Gram-negative organisms accounted for 25 of 42 recorded VAP isolates, while Staphylococcus haemolyticus was the single most common VAP isolate. MDR classifications varied by organism.ConclusionThese surveillance data characterize local DA-HAI patterns and support continued attention to device stewardship, microbiological surveillance, and antimicrobial stewardship.
SN - 2296-2565
ER -