Peer-reviewedCC BYACG case reports journal28 Oct 2026

Endoscopic Ultrasound-Guided Radiofrequency Ablation for an Adrenocorticotropic Hormone-Secreting Pancreatic Neuroendocrine Tumor on Antiplatelet Therapy.

Olivia Langton¹
Sai Sudha Valisekka¹
Rahul Karna²
Guru Trikudanathan²

¹Department of Internal Medicine, University of Minnesota, Minneapolis, MN.
²Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Minnesota, Minneapolis, MN.

Abstract

Endoscopic ultrasound (EUS)-guided radiofrequency ablation (RFA) has been used for thermal destruction of precancerous insulinomas and nonfunctioning pancreatic neuroendocrine tumors (pNETs) by coagulative necrosis. We report a case of a critically ill patient with an adrenocorticotropic hormone (ACTH)-secreting pNET treated with EUS-guided RFA (EUS-RFA) while on a P2Y12 antiplatelet after temporary stabilization on a titratable continuous etomidate infusion. This case demonstrates the novelty of EUS-RFA as a procedural treatment option for functional pNETs in critically ill, nonsurgical candidates on antiplatelet therapy.

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BibTeX RIS

BibTeX

@article{langton2026endoscopic,
  title = {{Endoscopic Ultrasound-Guided Radiofrequency Ablation for an Adrenocorticotropic Hormone-Secreting Pancreatic Neuroendocrine Tumor on Antiplatelet Therapy.}},
  author = {Olivia Langton and Sai Sudha Valisekka and Rahul Karna and Guru Trikudanathan},
  journal = {ACG case reports journal},
  year = {2026},
  month = oct,
  doi = {10.14309/crj.0000000000002374},
  url = {https://europepmc.org/article/MED/42953888},
  note = {CC BY},
}

RIS

TY  - JOUR
TI  - Endoscopic Ultrasound-Guided Radiofrequency Ablation for an Adrenocorticotropic Hormone-Secreting Pancreatic Neuroendocrine Tumor on Antiplatelet Therapy.
AU  - Olivia Langton
AU  - Sai Sudha Valisekka
AU  - Rahul Karna
AU  - Guru Trikudanathan
PY  - 2026
DA  - 2026/10/28
JO  - ACG case reports journal
DO  - 10.14309/crj.0000000000002374
UR  - https://europepmc.org/article/MED/42953888
AB  - Endoscopic ultrasound (EUS)-guided radiofrequency ablation (RFA) has been used for thermal destruction of precancerous insulinomas and nonfunctioning pancreatic neuroendocrine tumors (pNETs) by coagulative necrosis. We report a case of a critically ill patient with an adrenocorticotropic hormone (ACTH)-secreting pNET treated with EUS-guided RFA (EUS-RFA) while on a P2Y12 antiplatelet after temporary stabilization on a titratable continuous etomidate infusion. This case demonstrates the novelty of EUS-RFA as a procedural treatment option for functional pNETs in critically ill, nonsurgical candidates on antiplatelet therapy.
SN  - 2326-3253
ER  -

Abstract

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