The efficacy and safety of endoscopic resection for multiple rectal neuroendocrine tumors: a retrospective cohort study from a tertiary center
- 1Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, China
- 2Endoscopy Center, Shanghai Geriatric Medical Center, Shanghai, China
- 3Endoscopy Center, Minhang Hospital, Fudan University, Shanghai, China
Abstract
Background: Multiple rectal neuroendocrine tumors (MR-NETs) are rare. There is no consensus on their characteristics and treatment. We aimed to evaluate the efficacy and safety of endoscopic resection (ER) for MR-NETs.
Methods: We performed a retrospective review of 24 patients with 57 rectal NETs who underwent ER at Zhongshan Hospital, Fudan University. Baseline information, procedure-related characteristics and postoperative outcomes were analyzed.
Results: The mean maximal diameter was 8.2 ± 4.5 mm, with 43 lesions < 10 mm and 14 lesions ≥ 10 mm. Seventeen patients had 2 lesions, 6 patients had 3 lesions and 1 patient had 5 lesions. There were 53 lesions treated by endoscopic submucosal dissection, 2 lesions treated by endoscopic mucosal resection, and 2 lesions treated by endoscopic submucosal excavation. The en bloc resection rate and technical success rate were both 100%. There were no delayed bleeding or perforation. All patients were eventually discharged safely, with a mean post-procedure hospital stay of 1.81 ± 0.48 days. Tumor grade was G1 in 54 (94.7%) lesions and G2 in 3 lesions (5.3%). Positive margins were found in 10 lesions, including 2 lesions (3.5%) with lateral margin involvement, and 8 cases (14.0%) with basal margin involvement. Mean follow-up was 34.96 ± 23.20 months, with only 3 local recurrences which were successfully managed by salvage ER. There were no recurrences in the 10 lesions with positive margins.
Conclusions: ER is a safe and effective technique for small MR-NETs. Positive resection margins do not appear to adversely affect the prognosis of small MR-NETs. Salvage ER may be a viable option in recurrent cases.
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BibTeX
@article{xu2026efficacy,
title = {{The efficacy and safety of endoscopic resection for multiple rectal neuroendocrine tumors: a retrospective cohort study from a tertiary center}},
author = {Pei-Rong Xu and Zu-Qiang Liu and Yan-Fang Tan and Zi-Yu Wang and Meng-Jiang He and Quan-Lin Li and Ping-Hong Zhou and Hao Hu},
journal = {BMC Gastroenterology},
year = {2026},
month = oct,
doi = {10.1186/s12876-026-05317-z},
url = {https://doi.org/10.1186/s12876-026-05317-z},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - The efficacy and safety of endoscopic resection for multiple rectal neuroendocrine tumors: a retrospective cohort study from a tertiary center
AU - Pei-Rong Xu
AU - Zu-Qiang Liu
AU - Yan-Fang Tan
AU - Zi-Yu Wang
AU - Meng-Jiang He
AU - Quan-Lin Li
AU - Ping-Hong Zhou
AU - Hao Hu
PY - 2026
DA - 2026/10/07
JO - BMC Gastroenterology
DO - 10.1186/s12876-026-05317-z
UR - https://doi.org/10.1186/s12876-026-05317-z
AB - Background: Multiple rectal neuroendocrine tumors (MR-NETs) are rare. There is no consensus on their characteristics and treatment. We aimed to evaluate the efficacy and safety of endoscopic resection (ER) for MR-NETs. Methods: We performed a retrospective review of 24 patients with 57 rectal NETs who underwent ER at Zhongshan Hospital, Fudan University. Baseline information, procedure-related characteristics and postoperative outcomes were analyzed. Results: The mean maximal diameter was 8.2 ± 4.5 mm, with 43 lesions < 10 mm and 14 lesions ≥ 10 mm. Seventeen patients had 2 lesions, 6 patients had 3 lesions and 1 patient had 5 lesions. There were 53 lesions treated by endoscopic submucosal dissection, 2 lesions treated by endoscopic mucosal resection, and 2 lesions treated by endoscopic submucosal excavation. The en bloc resection rate and technical success rate were both 100%. There were no delayed bleeding or perforation. All patients were eventually discharged safely, with a mean post-procedure hospital stay of 1.81 ± 0.48 days. Tumor grade was G1 in 54 (94.7%) lesions and G2 in 3 lesions (5.3%). Positive margins were found in 10 lesions, including 2 lesions (3.5%) with lateral margin involvement, and 8 cases (14.0%) with basal margin involvement. Mean follow-up was 34.96 ± 23.20 months, with only 3 local recurrences which were successfully managed by salvage ER. There were no recurrences in the 10 lesions with positive margins. Conclusions: ER is a safe and effective technique for small MR-NETs. Positive resection margins do not appear to adversely affect the prognosis of small MR-NETs. Salvage ER may be a viable option in recurrent cases.
SN - 1471-230X
ER -