Effect of food-cues on aMCC glutamate modulation during inhibitory control post weight loss intervention: a 1H fMRS study
- 1Virginia Tech
Abstract
Objective: Poor inhibitory control may decrease weight loss maintenance. The neurobiological mechanisms are poorly understood. We investigated whether glutamate modulation in the anterior mid-cingulate cortex (aMCC) during response inhibition is impacted by food-cues and associated with self-reported behaviors and weight loss maintenance. Methods: 27 adults with overweight/obesity were recruited from a clinical weight management program. 1H fMRS (midline aMCC) was acquired during a visual-guided response inhibition task engaging two responding modes [non-selective (100% responses) or selective (withholding a response on 20% of trials)] applied with neutral (squares) or food/non-food cues. The impact of stimulus type on the aMCC glutamate modulation for each responding mode was assessed using a repeated measures GEE approach. Correlations were conducted between glutamate modulation, Three-Factor Eating Questionnaire scores, and long-term weight change. Results: The stimulus effect was significant during selective responding, driven by lower aMCC glutamate modulation during food/non-food cues. This glutamate modulation (selective; food/non-food) association with weight loss maintenance was a close trend (R2=0.15, p=0.054). The association with the TFEQ Cognitive Restraint was significant (R2=0.20, p=0.047). Conclusions: These results demonstrate an impact of food/non-food cues during response inhibition on the neurobiology and associations with long-term weight loss maintenance and scores related to eating behaviors.
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BibTeX
@misc{eichstaedt2026effect,
title = {{Effect of food-cues on aMCC glutamate modulation during inhibitory control post weight loss intervention: a 1H fMRS study}},
author = {J. M. Eichstaedt and R. Sochocki and D. Khatib and N. Miller and V. A. Diwadkar and P. Burghardt and A. Rothberg and J. A. Stanley},
howpublished = {medRxiv},
year = {2026},
month = oct,
doi = {10.64898/2026.10.27.26366634},
url = {https://www.medrxiv.org/content/10.64898/2026.10.27.26366634v1},
note = {CC BY-NC-ND},
}
RIS
TY - UNPB
TI - Effect of food-cues on aMCC glutamate modulation during inhibitory control post weight loss intervention: a 1H fMRS study
AU - J. M. Eichstaedt
AU - R. Sochocki
AU - D. Khatib
AU - N. Miller
AU - V. A. Diwadkar
AU - P. Burghardt
AU - A. Rothberg
AU - J. A. Stanley
PY - 2026
DA - 2026/10/27
PB - medRxiv
DO - 10.64898/2026.10.27.26366634
UR - https://www.medrxiv.org/content/10.64898/2026.10.27.26366634v1
AB - Objective: Poor inhibitory control may decrease weight loss maintenance. The neurobiological mechanisms are poorly understood. We investigated whether glutamate modulation in the anterior mid-cingulate cortex (aMCC) during response inhibition is impacted by food-cues and associated with self-reported behaviors and weight loss maintenance. Methods: 27 adults with overweight/obesity were recruited from a clinical weight management program. 1H fMRS (midline aMCC) was acquired during a visual-guided response inhibition task engaging two responding modes [non-selective (100% responses) or selective (withholding a response on 20% of trials)] applied with neutral (squares) or food/non-food cues. The impact of stimulus type on the aMCC glutamate modulation for each responding mode was assessed using a repeated measures GEE approach. Correlations were conducted between glutamate modulation, Three-Factor Eating Questionnaire scores, and long-term weight change. Results: The stimulus effect was significant during selective responding, driven by lower aMCC glutamate modulation during food/non-food cues. This glutamate modulation (selective; food/non-food) association with weight loss maintenance was a close trend (R2=0.15, p=0.054). The association with the TFEQ Cognitive Restraint was significant (R2=0.20, p=0.047). Conclusions: These results demonstrate an impact of food/non-food cues during response inhibition on the neurobiology and associations with long-term weight loss maintenance and scores related to eating behaviors.
ER -