Life's Essential 8 and Life's Crucial 9 as Prognostic Indicators for Hip Fracture Outcomes: A Multicenter Prospective Cohort Study.
- 1Department of Traumatic Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200092, People's Republic of China.
- 2Emergency Trauma Center, Nanyang Second People's Hospital, Nanyang, Henan, People's Republic of China.
- 3Department of Joint Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200092, People's Republic of China.
Abstract
Objective
To evaluate the prognostic utility of LE8 and LC9 for mortality and functional recovery following hip fracture surgery.Methods
This multicenter prospective cohort study enrolled 1796 patients aged 50 years or older who underwent surgical treatment for hip fracture at two tertiary medical institutions in China between January 2017 and December 2022. Patients were followed for 1 year post-surgery. LE8 and LC9 were calculated on the first day after admission. Discriminative performance was assessed using receiver operating characteristic curve analysis; independent prognostic value was determined using multivariable Cox proportional hazards and logistic regression models.Results
Among 1796 participants, 311 deaths (17.3%) occurred during 1-year follow-up. LC9 demonstrated superior predictive accuracy compared with LE8 for 1-year mortality and free walking ability. Patients with low LE8 and LC9 experienced dramatically elevated 1-year mortality rates and markedly reduced functional recovery. In multivariable analyses, increase in both LE8 and LC9 related to significant mortality risk reduction and improved functional recovery, independent of age, comorbidity burden, and surgical factors.Conclusions
In this multicenter prospective cohort study, LC9 was independently associated with mortality and functional recovery and demonstrated greater discriminative performance than LE8, with psychological health assessment providing critical incremental value. Integration of LC9 into clinical practice may enhance risk stratification and inform targeted perioperative interventions for this vulnerable population.
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BibTeX
@article{yang2026lifes,
title = {{Life's Essential 8 and Life's Crucial 9 as Prognostic Indicators for Hip Fracture Outcomes: A Multicenter Prospective Cohort Study.}},
author = {Chensong Yang and Mingchong Liu and Zhibang Zhao and Cong Lv and Yutao Pan and Guixin Sun and Feng Yin},
journal = {Clinical interventions in aging},
year = {2026},
month = oct,
doi = {10.2147/cia.s639216},
url = {https://europepmc.org/article/MED/42928905},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Life's Essential 8 and Life's Crucial 9 as Prognostic Indicators for Hip Fracture Outcomes: A Multicenter Prospective Cohort Study.
AU - Chensong Yang
AU - Mingchong Liu
AU - Zhibang Zhao
AU - Cong Lv
AU - Yutao Pan
AU - Guixin Sun
AU - Feng Yin
PY - 2026
DA - 2026/10/21
JO - Clinical interventions in aging
DO - 10.2147/cia.s639216
UR - https://europepmc.org/article/MED/42928905
AB - Objective To evaluate the prognostic utility of LE8 and LC9 for mortality and functional recovery following hip fracture surgery.Methods This multicenter prospective cohort study enrolled 1796 patients aged 50 years or older who underwent surgical treatment for hip fracture at two tertiary medical institutions in China between January 2017 and December 2022. Patients were followed for 1 year post-surgery. LE8 and LC9 were calculated on the first day after admission. Discriminative performance was assessed using receiver operating characteristic curve analysis; independent prognostic value was determined using multivariable Cox proportional hazards and logistic regression models.Results Among 1796 participants, 311 deaths (17.3%) occurred during 1-year follow-up. LC9 demonstrated superior predictive accuracy compared with LE8 for 1-year mortality and free walking ability. Patients with low LE8 and LC9 experienced dramatically elevated 1-year mortality rates and markedly reduced functional recovery. In multivariable analyses, increase in both LE8 and LC9 related to significant mortality risk reduction and improved functional recovery, independent of age, comorbidity burden, and surgical factors.Conclusions In this multicenter prospective cohort study, LC9 was independently associated with mortality and functional recovery and demonstrated greater discriminative performance than LE8, with psychological health assessment providing critical incremental value. Integration of LC9 into clinical practice may enhance risk stratification and inform targeted perioperative interventions for this vulnerable population.
SN - 1176-9092
SN - 1178-1998
ER -