Rational and design of the FREESCA study: A multicenter prospective study assessing the prognostic value of continuous glucose monitoring during hospitalization for acute coronary syndrome
Abstract
Background Hyperglycemia and glycemic variability are recognized as major prognostic factors after acute coronary syndrome (ACS), yet most studies rely on single-point glucose measurements or short-term monitoring. Aim To describe the rational and the design of the FREESCA study, which aims to evaluate the prognostic value of glycemic parameters recorded by a professional continuous glucose monitoring (CGM) device during the index hospitalization for ACS. Methods FREESCA is a prospective, observational, multicenter study planned to enroll 850 adults admitted to intensive cardiac care units for ACS (STEMI or NSTEMI). A Freestyle Libre Pro sensor® is placed at admission and records interstitial glucose continuously throughout hospitalization. Parameters include mean glucose, time in range (TIR), time above range (TAR), time below range (TBR), coefficient of variation (CV), mean amplitude of glycemic excursions (MAGE), and glucose management indicator (GMI). The primary endpoint is the occurrence of major adverse cardiovascular events (MACE) at 12 months. Conclusions FREESCA is one of the largest studies to integrate full-hospitalization CGM data in ACS patients regardless of diabetes status, aiming to develop a robust prognostic model. Trial registration ClinicalTrials.gov identifier [ NCT06014112 ].
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BibTeX
@article{tournayre2026rational,
title = {{Rational and design of the FREESCA study: A multicenter prospective study assessing the prognostic value of continuous glucose monitoring during hospitalization for acute coronary syndrome}},
author = {Sarah Tournayre and Edouard Gerbaud and Pierre Poustis and Bogdan Catargi and Christel Voinot and Meyer Elbaz and Pierre Gourdy and Benoit Lattuca and Véronique Taillard and Patrick Henry and Jean-François Gauthier and Frédéric Georger and Jean-Michel Andrieu and Etienne Puymirat and Fabien Huet and Gwenaelle Arnault and Nicolas Nagot and François Roubille and Ariane Sultan},
journal = {American Heart Journal Plus: Cardiology Research and Practice},
year = {2026},
month = nov,
doi = {10.1016/j.ahjo.2026.100950},
url = {https://hal.science/hal-05854560v1},
note = {CC BY},
}
RIS
TY - JOUR
TI - Rational and design of the FREESCA study: A multicenter prospective study assessing the prognostic value of continuous glucose monitoring during hospitalization for acute coronary syndrome
AU - Sarah Tournayre
AU - Edouard Gerbaud
AU - Pierre Poustis
AU - Bogdan Catargi
AU - Christel Voinot
AU - Meyer Elbaz
AU - Pierre Gourdy
AU - Benoit Lattuca
AU - Véronique Taillard
AU - Patrick Henry
AU - Jean-François Gauthier
AU - Frédéric Georger
AU - Jean-Michel Andrieu
AU - Etienne Puymirat
AU - Fabien Huet
AU - Gwenaelle Arnault
AU - Nicolas Nagot
AU - François Roubille
AU - Ariane Sultan
PY - 2026
DA - 2026/11/06
JO - American Heart Journal Plus: Cardiology Research and Practice
DO - 10.1016/j.ahjo.2026.100950
UR - https://hal.science/hal-05854560v1
AB - Background Hyperglycemia and glycemic variability are recognized as major prognostic factors after acute coronary syndrome (ACS), yet most studies rely on single-point glucose measurements or short-term monitoring. Aim To describe the rational and the design of the FREESCA study, which aims to evaluate the prognostic value of glycemic parameters recorded by a professional continuous glucose monitoring (CGM) device during the index hospitalization for ACS. Methods FREESCA is a prospective, observational, multicenter study planned to enroll 850 adults admitted to intensive cardiac care units for ACS (STEMI or NSTEMI). A Freestyle Libre Pro sensor® is placed at admission and records interstitial glucose continuously throughout hospitalization. Parameters include mean glucose, time in range (TIR), time above range (TAR), time below range (TBR), coefficient of variation (CV), mean amplitude of glycemic excursions (MAGE), and glucose management indicator (GMI). The primary endpoint is the occurrence of major adverse cardiovascular events (MACE) at 12 months. Conclusions FREESCA is one of the largest studies to integrate full-hospitalization CGM data in ACS patients regardless of diabetes status, aiming to develop a robust prognostic model. Trial registration ClinicalTrials.gov identifier [ NCT06014112 ].
SN - 2666-6022
SN - 2666-6022
ER -