Surface Modification of ZnO Nanoparticles with L-Serine and Preliminary Antibacterial Properties Against Escherichia coli
4 affiliations
- 1Facultad de Ingeniería, Universidad Autónoma de Coahuila, Arteaga 25350, Coahuila, Mexico
- 2Departamento de Metal Mecánica, Tecnológico Nacional de México/I.T. Saltillo, Saltillo 25280, Coahuila, Mexico
- 3Centro de Investigación en Química Aplicada, Saltillo 25294, Coahuila, Mexico
- 4Investigador por México Secihti-CIQA, Av. Insurgentes Sur 1562, Col. Crédito Constructor, Alcaldía Benito Juárez, Ciudad de Mexico 03940, Mexico
Abstract
Due to bacterial mutation and evolution to survive and to the misuse of antibiotics, there is greater resistance to different medications among different bacteria. This study presents the modification of ZnO nanoparticles with L-serine via ultrasound, their physicochemical evaluation, and antibacterial performance against Escherichia coli (E. coli). Among the most significant results are: by FT-IR, a union between the carbonyl and amino groups of two L-serine amino acids was observed, indicating the formation of a peptide bond corresponding to amide group II. In the TGA of the samples modified with L-serine, weight losses between 360 and 455 °C were observed, supporting that the chemical modification was effective for both reaction times (60 and 90 min). In XRD, it could be observed that the characteristic peak of L-serine is at 22.8°, and there are other signals that oscillate between 10 and 20° of the peptide interlaces formed between the amino acids present in the modified particles. XPS analysis showed that, for the samples modified with L-serine, the N1s and C1s signals appeared, and deconvolution was performed for these signals in order to see their interactions in the chemical environment. The value of zeta potential of the sample ZnOMOD90 showed a bigger change. TEM images indicated that the ZnO pure nanoparticles have a hemispherical morphology and a size of approximately 24 nm, while ZnOMOD90 nanoparticles have a size of approximately 53 nm. Modified ZnO nanoparticles increased the inhibition zone halo for the ZnOMOD90 sample to 31 mm against E. coli bacteria, compared to pure ZnO, which had an inhibition zone of only 1 mm.
Related
- Screening Endophytic Fungi of Australian Indigenous Plants for Biosynthesis of Silver Nanoparticles and Evaluation of Their Antibacterial Properties
- Impact of shape modification of cobalt-ferrite nanoparticles on their magnetic and magnetothermal properties for magnetic hyperthermia
- Ultrasonic-assisted green synthesis of schiff base-functionalized CdS nanoparticles with enhanced optical, anticancer, and antibacterial properties
- Bio-inspired decoration of Ag nanoparticles on eggshell-derived hierarchical CaO-based flower-like architectures for enhanced antibacterial, photocatalytic, and hemocompatible applications
- Mechanism‐Guided Engineering of Upconversion Nanoparticles for Antibacterial Phototherapy: From Photonic Principles to Translational Nanosystems
BibTeX
@article{andradeguel2026surface,
title = {{Surface Modification of ZnO Nanoparticles with L-Serine and Preliminary Antibacterial Properties Against Escherichia coli}},
author = {Marlene Andrade-Guel and Juan Carlos Ortiz-Cuellar and Jesús Fernando Martínez-Villafañe and Nelly Abigaíl Rodríguez-Rosales and Enrique Díaz Barriga-Castro and Carlos Rodrigo Muñiz-Valdez and Christian J. Cabello-Alvarado and Jesús Salvador Galindo-Valdés},
journal = {Inorganics},
year = {2026},
month = oct,
doi = {10.3390/inorganics14100266},
url = {https://www.mdpi.com/2304-6740/14/10/266},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Surface Modification of ZnO Nanoparticles with L-Serine and Preliminary Antibacterial Properties Against Escherichia coli
AU - Marlene Andrade-Guel
AU - Juan Carlos Ortiz-Cuellar
AU - Jesús Fernando Martínez-Villafañe
AU - Nelly Abigaíl Rodríguez-Rosales
AU - Enrique Díaz Barriga-Castro
AU - Carlos Rodrigo Muñiz-Valdez
AU - Christian J. Cabello-Alvarado
AU - Jesús Salvador Galindo-Valdés
PY - 2026
DA - 2026/10/20
JO - Inorganics
DO - 10.3390/inorganics14100266
UR - https://www.mdpi.com/2304-6740/14/10/266
AB - Due to bacterial mutation and evolution to survive and to the misuse of antibiotics, there is greater resistance to different medications among different bacteria. This study presents the modification of ZnO nanoparticles with L-serine via ultrasound, their physicochemical evaluation, and antibacterial performance against Escherichia coli (E. coli). Among the most significant results are: by FT-IR, a union between the carbonyl and amino groups of two L-serine amino acids was observed, indicating the formation of a peptide bond corresponding to amide group II. In the TGA of the samples modified with L-serine, weight losses between 360 and 455 °C were observed, supporting that the chemical modification was effective for both reaction times (60 and 90 min). In XRD, it could be observed that the characteristic peak of L-serine is at 22.8°, and there are other signals that oscillate between 10 and 20° of the peptide interlaces formed between the amino acids present in the modified particles. XPS analysis showed that, for the samples modified with L-serine, the N1s and C1s signals appeared, and deconvolution was performed for these signals in order to see their interactions in the chemical environment. The value of zeta potential of the sample ZnOMOD90 showed a bigger change. TEM images indicated that the ZnO pure nanoparticles have a hemispherical morphology and a size of approximately 24 nm, while ZnOMOD90 nanoparticles have a size of approximately 53 nm. Modified ZnO nanoparticles increased the inhibition zone halo for the ZnOMOD90 sample to 31 mm against E. coli bacteria, compared to pure ZnO, which had an inhibition zone of only 1 mm.
SN - 2304-6740
ER -