Impact of shape modification of cobalt-ferrite nanoparticles on their magnetic and magnetothermal properties for magnetic hyperthermia
8 affiliations
- 1Institute of Physics, Faculty of Science, P.J. Šafárik University, Park Angelinum 9, Košice, 04001, Slovakia
- 2Institute of Physics, Faculty of Science, P.J. Šafárik University, Park Angelinum 9, Košice, 04001, Slovakia. [email protected]
- 3Department of Chemistry and Industrial Chemistry, University of Genoa, Dodecaneso 31, 1-16146, Genova, Italy
- 4Friedrich-Alexander-Universität Erlangen-Nürnberg, Erwin-Rommel-Straße 1, 91058, Erlangen, Germany
- 5Department of Theoretical Physics and Condensed Matter Physics, VINČA Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia
- 6Department of Inorganic Chemistry, Faculty of Science, Charles University, Hlavova 2030/8, Prague 2, 128 00, Czech Republic
- 7Institut Laue-Langevin, The European Neutron Source, 71 Avenue des Martyrs, Grenoble, 38042, France
- 8Institute of Biology and Ecology, Faculty of Science, P.J. Šafárik University in Košice, Šrobárova 2, Košice, 04154, Slovakia
Abstract
Cobalt-ferrite magnetic nanoparticles (MNPs) exhibiting three distinct morphologies: spherical, cubic, and octopod-like, with perfect shape resolution and a very narrow size distribution, were successfully synthesised by the thermal decomposition method. The influence of particle shape on the structural, magnetic, and magneto-thermal properties was systematically investigated. The magneto-thermal performance was evaluated under AC fields with varying amplitudes and frequencies and quantified using the SAR and ILP parameters. A pronounced dependence of heating efficiency on particle morphology was observed. Cubic nanoparticles exhibited the highest magneto-thermal performance, reaching SAR values up to 411 W/g at applied field ∼20 kA/m and 728 kHz, whereas spherical nanoparticles showed negligible heating, and octopod particles exhibited intermediate performance. These differences are interpreted within the framework of linear response theory, highlighting the roles of effective magnetic anisotropy and interparticle interactions in governing the magneto-thermal response. The response of A549 and HT-29 cancer cells to cobalt-ferrite nanoparticles was found to be strongly concentration-dependent. At a concentration of 100 µg/mL, cubic nanoparticles exhibited the weakest inhibitory effect, while lower concentrations were well tolerated without a significant morphology-dependent effect. Overall, the results underline the importance of morphology control in the design of efficient and biocompatible cobalt-ferrite nanoparticles for magnetic hyperthermia applications.
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BibTeX
@article{nagy2026impact,
title = {{Impact of shape modification of cobalt-ferrite nanoparticles on their magnetic and magnetothermal properties for magnetic hyperthermia}},
author = {Ľuboš Nagy and A. Zeleňáková and Pavol Hrubovčák and Žaneta Fabriciová and Michael Barutiak and Dominik Volavka and Tomáš Samuely and Maksym Lisnichuk and Ana Mraković and Dominika Zákutná and Zuzana Jendželovská and Ivana BARČÁKOVÁ and Rastislav Jendželovský},
journal = {Scientific Reports},
year = {2026},
month = may,
doi = {10.1038/s41598-026-53007-3},
url = {https://doi.org/10.1038/s41598-026-53007-3},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Impact of shape modification of cobalt-ferrite nanoparticles on their magnetic and magnetothermal properties for magnetic hyperthermia
AU - Ľuboš Nagy
AU - A. Zeleňáková
AU - Pavol Hrubovčák
AU - Žaneta Fabriciová
AU - Michael Barutiak
AU - Dominik Volavka
AU - Tomáš Samuely
AU - Maksym Lisnichuk
AU - Ana Mraković
AU - Dominika Zákutná
AU - Zuzana Jendželovská
AU - Ivana BARČÁKOVÁ
AU - Rastislav Jendželovský
PY - 2026
DA - 2026/05/13
JO - Scientific Reports
DO - 10.1038/s41598-026-53007-3
UR - https://doi.org/10.1038/s41598-026-53007-3
AB - Cobalt-ferrite magnetic nanoparticles (MNPs) exhibiting three distinct morphologies: spherical, cubic, and octopod-like, with perfect shape resolution and a very narrow size distribution, were successfully synthesised by the thermal decomposition method. The influence of particle shape on the structural, magnetic, and magneto-thermal properties was systematically investigated. The magneto-thermal performance was evaluated under AC fields with varying amplitudes and frequencies and quantified using the SAR and ILP parameters. A pronounced dependence of heating efficiency on particle morphology was observed. Cubic nanoparticles exhibited the highest magneto-thermal performance, reaching SAR values up to 411 W/g at applied field ∼20 kA/m and 728 kHz, whereas spherical nanoparticles showed negligible heating, and octopod particles exhibited intermediate performance. These differences are interpreted within the framework of linear response theory, highlighting the roles of effective magnetic anisotropy and interparticle interactions in governing the magneto-thermal response. The response of A549 and HT-29 cancer cells to cobalt-ferrite nanoparticles was found to be strongly concentration-dependent. At a concentration of 100 µg/mL, cubic nanoparticles exhibited the weakest inhibitory effect, while lower concentrations were well tolerated without a significant morphology-dependent effect. Overall, the results underline the importance of morphology control in the design of efficient and biocompatible cobalt-ferrite nanoparticles for magnetic hyperthermia applications.
SN - 2045-2322
ER -