Congenital Chloride Diarrhea Presenting With Polyhydramnios and Preterm Labor at 26 Weeks of Gestation: Prenatal and Neonatal Management
- 1Department of Obstetrics and Gynaecology, Mohammed V Military University Hospital, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, MAR
Abstract
Congenital chloride diarrhea (CCD) is a rare autosomal recessive disorder linked to a dysfunction of the intestinal ion transporter. Its prenatal diagnosis relies on the combination of polyhydramnios and dilated fetal intestinal loops on ultrasound. We report the case of a 26-year-old woman, gravida 3, para 1, admitted at 26 weeks of gestation for threatened preterm labor due to acute polyhydramnios. Conservative management allowed the pregnancy to continue until 34 weeks of gestation, at which point a cesarean section was performed due to acute fetal distress. The newborn presented with watery diarrhea from birth. Initial intravenous rehydration with normal saline, combined with appropriate fluid and electrolyte supplementation, corrected the dehydration, electrolyte imbalance, and metabolic alkalosis, leading to a favorable clinical outcome.
Related
- Planned early birth versus expectant management for hypertensive disorders from 34 weeks' gestation to term
- Beyond Primary Epilepsy: Fahr's Syndrome Secondary to Congenital Parathyroid Agenesis Presenting With Generalised Seizures in a Young Adult
- Case Report: Giant congenital hydronephrosis presenting as massive retroperitoneal cystic lesion with literature review
- Heterotopic Cutaneous Adnexa Arising from the Ascending Colon Presenting as a Chronic Abdominal Wall Sinus: A Rare Congenital Anomaly and Diagnostic Challenge
- Acute Hemorrhagic Manifestations in a Pregnant Patient With Type 1 von Willebrand Disease: Challenges in Management of Bleeding Disorders During Gestation
BibTeX
@article{mangoub2026congenital,
title = {{Congenital Chloride Diarrhea Presenting With Polyhydramnios and Preterm Labor at 26 Weeks of Gestation: Prenatal and Neonatal Management}},
author = {Fatima El Mangoub and Abdelhamid Benlghazi and Bouhtouri Yassine and Mly Mehdi Elhassani and Kouach Jaouad},
journal = {Cureus},
year = {2026},
month = oct,
doi = {10.7759/cureus.117296},
url = {https://europepmc.org/article/PMC/PMC13723188},
note = {CC BY},
}
RIS
TY - JOUR
TI - Congenital Chloride Diarrhea Presenting With Polyhydramnios and Preterm Labor at 26 Weeks of Gestation: Prenatal and Neonatal Management
AU - Fatima El Mangoub
AU - Abdelhamid Benlghazi
AU - Bouhtouri Yassine
AU - Mly Mehdi Elhassani
AU - Kouach Jaouad
PY - 2026
DA - 2026/10/01
JO - Cureus
DO - 10.7759/cureus.117296
UR - https://europepmc.org/article/PMC/PMC13723188
AB - Congenital chloride diarrhea (CCD) is a rare autosomal recessive disorder linked to a dysfunction of the intestinal ion transporter. Its prenatal diagnosis relies on the combination of polyhydramnios and dilated fetal intestinal loops on ultrasound. We report the case of a 26-year-old woman, gravida 3, para 1, admitted at 26 weeks of gestation for threatened preterm labor due to acute polyhydramnios. Conservative management allowed the pregnancy to continue until 34 weeks of gestation, at which point a cesarean section was performed due to acute fetal distress. The newborn presented with watery diarrhea from birth. Initial intravenous rehydration with normal saline, combined with appropriate fluid and electrolyte supplementation, corrected the dehydration, electrolyte imbalance, and metabolic alkalosis, leading to a favorable clinical outcome.
SN - 2168-8184
ER -