Preventing regrettable substitutions: a proposal for a tiered testing approach for BPA alternatives under the PARC initiative
Abstract
Bisphenol A (BPA) alternatives are increasingly used in the manufacture of industrial and consumer products, following regulatory restrictions on BPA. However, insufficient safety data on these substitutes raise concern as regards potential regrettable substitutions. Under the EU Partnership for the Assessment of Risks from Chemicals (PARC), Work Package 5 (WP5) addresses this challenge by applying a human-relevant tiered hazard assessment strategy grounded on OECD test guidelines as first tier and expanding the battery to include NAMs (New Approach Methodologies). Eight BPA alternatives were prioritized for studies addressing key toxicological endpoints, namely, endocrine disruption (ED), developmental neurotoxicity (DNT), immunotoxicity, genotoxicity and carcinogenicity and metabolic fate examination (detoxification vs. potential bioactivation), to enable early identification of biological activity and support cross-endpoint prioritization. This manuscript describes the structure and implementation of the testing framework. This integrated testing strategy proposes a structured approach to identify substances of potential concern, guide targeted higher-tier studies, and support regulatory prioritization. PARC WP5 framework is testing whether coordinated NAM-based methods may contribute to next-generation risk assessment and help prevent regrettable substitutions among BPA alternatives for rapid regulatory adoption. Detailed experimental results will be reported separately upon completion of the project.
Related
- Proposal for preventing fatal nitrogen gas inhalation while working: an autopsy case and review of the literature
- Profiling Amino Acid Substitutions in Proteomic Datasets of Alzheimer’s Disease Reveals Biological Significance
- Distal amino-acid substitutions contribute to HIV protease inhibitor resistance as directly as proximal amino-acid substitutions
- Bridging Conventional and Natural Therapies for Recurrent Aphthous Stomatitis: A Systematic Review and Meta-Analysis of Triamcinolone and Non-Steroidal Alternatives
- Cathepsin resistance mediated by key amino acid substitutions drives intracellular crystallization in light chain proximal tubulopathy
BibTeX
@article{aielloholden2026preventing,
title = {{Preventing regrettable substitutions: a proposal for a tiered testing approach for BPA alternatives under the PARC initiative}},
author = {Kiara Aiello-Holden and Kristina Bartmann and Franca Maria Buratti and Nicolas Cabaton and Lucia Coppola and Emanuela Corsini and Antonio de la Vieja and Hubert Dirven and Maria Dusinska and Naouale El Yamani and Nina Franko and Johanna Gostner and Nathalie Grova and Louise Gütter and Patricia Iglesias-Hernández and Martina Iulini and Anja Kodila and Yvonne Kohl and Gabriele Lori and Henriqueta Louro and Francesca Marcon and Sakina Mhaouty-Kodja and Archibold Mposhi and Lydie Naulé and Simonetta Palleschi and Barbara Rossi and Elise Rundén-Pran and Francesca Salani and Nicoletta Santori and Maria João Silva and Marija Sollner Dolenc and Emanuela Testai and Mónica Torres-Ruiz and Jonathan Turner and Catherine Viguié and Daniel Zalko and Sabrina Tait},
journal = {Frontiers in Toxicology},
year = {2026},
month = jul,
doi = {10.3389/ftox.2026.1815869},
url = {https://hal.science/hal-05783290v1},
note = {CC BY},
}
RIS
TY - JOUR
TI - Preventing regrettable substitutions: a proposal for a tiered testing approach for BPA alternatives under the PARC initiative
AU - Kiara Aiello-Holden
AU - Kristina Bartmann
AU - Franca Maria Buratti
AU - Nicolas Cabaton
AU - Lucia Coppola
AU - Emanuela Corsini
AU - Antonio de la Vieja
AU - Hubert Dirven
AU - Maria Dusinska
AU - Naouale El Yamani
AU - Nina Franko
AU - Johanna Gostner
AU - Nathalie Grova
AU - Louise Gütter
AU - Patricia Iglesias-Hernández
AU - Martina Iulini
AU - Anja Kodila
AU - Yvonne Kohl
AU - Gabriele Lori
AU - Henriqueta Louro
AU - Francesca Marcon
AU - Sakina Mhaouty-Kodja
AU - Archibold Mposhi
AU - Lydie Naulé
AU - Simonetta Palleschi
AU - Barbara Rossi
AU - Elise Rundén-Pran
AU - Francesca Salani
AU - Nicoletta Santori
AU - Maria João Silva
AU - Marija Sollner Dolenc
AU - Emanuela Testai
AU - Mónica Torres-Ruiz
AU - Jonathan Turner
AU - Catherine Viguié
AU - Daniel Zalko
AU - Sabrina Tait
PY - 2026
DA - 2026/07/09
JO - Frontiers in Toxicology
DO - 10.3389/ftox.2026.1815869
UR - https://hal.science/hal-05783290v1
AB - Bisphenol A (BPA) alternatives are increasingly used in the manufacture of industrial and consumer products, following regulatory restrictions on BPA. However, insufficient safety data on these substitutes raise concern as regards potential regrettable substitutions. Under the EU Partnership for the Assessment of Risks from Chemicals (PARC), Work Package 5 (WP5) addresses this challenge by applying a human-relevant tiered hazard assessment strategy grounded on OECD test guidelines as first tier and expanding the battery to include NAMs (New Approach Methodologies). Eight BPA alternatives were prioritized for studies addressing key toxicological endpoints, namely, endocrine disruption (ED), developmental neurotoxicity (DNT), immunotoxicity, genotoxicity and carcinogenicity and metabolic fate examination (detoxification vs. potential bioactivation), to enable early identification of biological activity and support cross-endpoint prioritization. This manuscript describes the structure and implementation of the testing framework. This integrated testing strategy proposes a structured approach to identify substances of potential concern, guide targeted higher-tier studies, and support regulatory prioritization. PARC WP5 framework is testing whether coordinated NAM-based methods may contribute to next-generation risk assessment and help prevent regrettable substitutions among BPA alternatives for rapid regulatory adoption. Detailed experimental results will be reported separately upon completion of the project.
SN - 2673-3080
ER -