Brain functional changes of suicidal ideation and behaviours: a meta-analysis of task-based fMRI studies.
- 1Department of Psychology, The University of Hong Kong, Hong Kong S.A.R., China.
- 2Department of Psychology, The University of Hong Kong, Hong Kong S.A.R., China. [email protected].
Abstract
Background
Suicidal ideation and behaviour are major global mental health issues and leading causes for mortality. While existing evidence indicates brain functional deficits of suicidal thoughts and behaviours, the neural underpinnings of these deficits remain unclear, possibly due to various sources of methodological heterogeneities.Methods
We conducted a pre-registered meta-analysis including 22 task-based functional magnetic resonance imaging studies that compared suicidal individuals (N = 459, 63.83% females) with non-suicidal psychiatric controls (N = 681, 52.72% females). Separate analyses were conducted in the emotion and non-emotion (cognitive and risky decision making) domains. Subgroup and meta-regression analyses addressed methodological heterogeneities including patient diagnosis, suicidal characteristics (ideation vs. behaviours) and task type.Results
In emotion tasks, general suicidality (pooling across ideation and behaviours) and suicidal behaviours were both associated with hyperactivities in the left sensorimotor cortices and hippocampus/parahippocampus, alongside hypoactivity in the bilateral visual cortices. However, only the hypoactivity among visual areas was consistently replicated in all subgroup analyses. In non-emotion tasks, general suicidality and suicidal behaviours were both associated with hyperactivity in the left precentral gyrus and the right middle temporal gyrus, which were consistently replicated in all subgroup analyses. Meta-regression analyses further identified larger suicidality-associated functional changes in frontotemporal regions in studies with higher female proportions, and in hippocampal and temporal regions in studies with older participants.Conclusions
Our findings indicate that the blunted perceptual emotion processing and heightened motor system reactivity are key neural features of suicidality, which provide potential neural targets for interventions on suicidal individuals.
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BibTeX
@article{xu2026brain,
title = {{Brain functional changes of suicidal ideation and behaviours: a meta-analysis of task-based fMRI studies.}},
author = {Viktor Enshuo Xu and Kay Ke Fang and Robin Shao},
journal = {Translational psychiatry},
year = {2026},
month = jul,
doi = {10.1038/s41398-026-04293-y},
url = {https://europepmc.org/article/MED/42893975},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Brain functional changes of suicidal ideation and behaviours: a meta-analysis of task-based fMRI studies.
AU - Viktor Enshuo Xu
AU - Kay Ke Fang
AU - Robin Shao
PY - 2026
DA - 2026/07/01
JO - Translational psychiatry
DO - 10.1038/s41398-026-04293-y
UR - https://europepmc.org/article/MED/42893975
AB - Background Suicidal ideation and behaviour are major global mental health issues and leading causes for mortality. While existing evidence indicates brain functional deficits of suicidal thoughts and behaviours, the neural underpinnings of these deficits remain unclear, possibly due to various sources of methodological heterogeneities.Methods We conducted a pre-registered meta-analysis including 22 task-based functional magnetic resonance imaging studies that compared suicidal individuals (N = 459, 63.83% females) with non-suicidal psychiatric controls (N = 681, 52.72% females). Separate analyses were conducted in the emotion and non-emotion (cognitive and risky decision making) domains. Subgroup and meta-regression analyses addressed methodological heterogeneities including patient diagnosis, suicidal characteristics (ideation vs. behaviours) and task type.Results In emotion tasks, general suicidality (pooling across ideation and behaviours) and suicidal behaviours were both associated with hyperactivities in the left sensorimotor cortices and hippocampus/parahippocampus, alongside hypoactivity in the bilateral visual cortices. However, only the hypoactivity among visual areas was consistently replicated in all subgroup analyses. In non-emotion tasks, general suicidality and suicidal behaviours were both associated with hyperactivity in the left precentral gyrus and the right middle temporal gyrus, which were consistently replicated in all subgroup analyses. Meta-regression analyses further identified larger suicidality-associated functional changes in frontotemporal regions in studies with higher female proportions, and in hippocampal and temporal regions in studies with older participants.Conclusions Our findings indicate that the blunted perceptual emotion processing and heightened motor system reactivity are key neural features of suicidality, which provide potential neural targets for interventions on suicidal individuals.
SN - 2158-3188
ER -