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Peer-reviewedCC BY 4.0Nucleic Acids Research

OAS-nano: the Observed VHH Space Database

  • Clare M C Gillis1
  • Klara Kropivšek Brumat2
  • Ario de Marco2
  • Olga Obrezanova3
  • Erwin De Genst3
  • Rebecca Croasdale-Wood3
  • Charlotte M Deane1
  • Matthew I J Raybould1
  1. 1Oxford Protein Informatics Group, Department of Statistics, University of Oxford , OX1 3LB,Oxford,
  2. 2Laboratory for Environmental and Life Sciences, University of Nova Gorica , 5000,Nova Gorica,
  3. 3Biologics Engineering, Oncology R&D, AstraZeneca , Cambridge,CB2 0AA,
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Abstract

VHHs, the variable regions of camelid heavy-chain antibodies, are increasingly used as therapeutic, diagnostic, and research tools because of their small size and stability. Despite the growing number of publicly available VHH repertoire sequencing studies, there is no large-scale, web-accessible database of VHH sequences. Here, we present OAS-nano, a database containing over 73 million unique VHH sequences collected from 16 public repertoire sequencing datasets and 1 previously unpublished dataset, spanning alpaca, llama, and Bactrian camel repertoires. Sequence reads were processed using a standardized pipeline to extract high-quality VHH sequences. Experimental metadata and sequence annotations enable users to identify sequences appropriate for their use case. OAS-nano is freely available at https://oas-nano.opig.stats.ox.ac.uk/.

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Cite

BibTeXRIS
BibTeX
@article{gillis2026oasnano,
  title = {{OAS-nano: the Observed VHH Space Database}},
  author = {Clare M C Gillis and Klara Kropivšek Brumat and Ario de Marco and Olga Obrezanova and Erwin De Genst and Rebecca Croasdale-Wood and Charlotte M Deane and Matthew I J Raybould},
  journal = {Nucleic Acids Research},
  year = {2026},
  month = oct,
  doi = {10.1093/nar/gkag1009},
  url = {https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkag1009/8916834},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - OAS-nano: the Observed VHH Space Database
AU  - Clare M C Gillis
AU  - Klara Kropivšek Brumat
AU  - Ario de Marco
AU  - Olga Obrezanova
AU  - Erwin De Genst
AU  - Rebecca Croasdale-Wood
AU  - Charlotte M Deane
AU  - Matthew I J Raybould
PY  - 2026
DA  - 2026/10/15
JO  - Nucleic Acids Research
DO  - 10.1093/nar/gkag1009
UR  - https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkag1009/8916834
AB  - VHHs, the variable regions of camelid heavy-chain antibodies, are increasingly used as therapeutic, diagnostic, and research tools because of their small size and stability. Despite the growing number of publicly available VHH repertoire sequencing studies, there is no large-scale, web-accessible database of VHH sequences. Here, we present OAS-nano, a database containing over 73 million unique VHH sequences collected from 16 public repertoire sequencing datasets and 1 previously unpublished dataset, spanning alpaca, llama, and Bactrian camel repertoires. Sequence reads were processed using a standardized pipeline to extract high-quality VHH sequences. Experimental metadata and sequence annotations enable users to identify sequences appropriate for their use case. OAS-nano is freely available at https://oas-nano.opig.stats.ox.ac.uk/.
SN  - 0305-1048
SN  - 1362-4962
ER  -