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Peer-reviewedCC BY-NC-NDInternational journal of colorectal disease

Clinicopathological characteristics and outcomes of rectal neuroendocrine tumors according to resection modality.

  • Wanrong Zhou1
  • Qi Cheng1
  • Xiaolin Lin2
  • Xialu Hong1
  • Ziyu Tai1
  • Wan Du3
  • Xiuying Xiao4
  • Hua Xiong5
5 affiliations
  1. 1Division of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease NHC Key Laboratory of Digestive Diseases Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200001, China.
  2. 2Department of Oncology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China.
  3. 3Division of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease NHC Key Laboratory of Digestive Diseases Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200001, China. [email protected].
  4. 4Department of Oncology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China. [email protected].
  5. 5Division of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease NHC Key Laboratory of Digestive Diseases Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200001, China. [email protected].
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Abstract

Background

This study aimed to compare the effects of different treatment methods on the postoperative results and long-term prognosis of patients with 1-2 cm rectal neuroendocrine tumors (R-NETs), and provide evidence-based guidance for the treatment decision-making of this specific tumor size.Methods

The retrospective cohort study of this single-center included 736 patients with pathologically diagnosed R-NETs who were treated from January 2013 to August 2024. According to the treatment received, the patients were divided into endoscopic resection group (ER), local surgery group (LS) and radical surgery group (RS). The primary endpoint was recurrence free survival (RFS).Results

A total of 736 R-NETs patients were enrolled. For the controversial 1-2 cm tumor, there was no significant difference in the long-term RFS between the LS group and the ER group (P = 0.280), and the postoperative hospitalization days of the LS group was relatively short (median 2 days vs. 3 days, P < 0.001). Sensitivity analysis using propensity score matching (PSM) further confirmed these outcomes in postoperative hospitalization days (P < 0.001).Conclusion

For 1-2 cm R-NETs, recurrence events were rare in both treatment groups, and local surgery was associated with a shorter postoperative hospital stay.

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Cite

BibTeXRIS
BibTeX
@article{zhou2026clinicopathological,
  title = {{Clinicopathological characteristics and outcomes of rectal neuroendocrine tumors according to resection modality.}},
  author = {Wanrong Zhou and Qi Cheng and Xiaolin Lin and Xialu Hong and Ziyu Tai and Wan Du and Xiuying Xiao and Hua Xiong},
  journal = {International journal of colorectal disease},
  year = {2026},
  month = oct,
  doi = {10.1007/s00384-026-05247-y},
  url = {https://europepmc.org/article/MED/42895569},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Clinicopathological characteristics and outcomes of rectal neuroendocrine tumors according to resection modality.
AU  - Wanrong Zhou
AU  - Qi Cheng
AU  - Xiaolin Lin
AU  - Xialu Hong
AU  - Ziyu Tai
AU  - Wan Du
AU  - Xiuying Xiao
AU  - Hua Xiong
PY  - 2026
DA  - 2026/10/12
JO  - International journal of colorectal disease
DO  - 10.1007/s00384-026-05247-y
UR  - https://europepmc.org/article/MED/42895569
AB  - Background  This study aimed to compare the effects of different treatment methods on the postoperative results and long-term prognosis of patients with 1-2 cm rectal neuroendocrine tumors (R-NETs), and provide evidence-based guidance for the treatment decision-making of this specific tumor size.Methods  The retrospective cohort study of this single-center included 736 patients with pathologically diagnosed R-NETs who were treated from January 2013 to August 2024. According to the treatment received, the patients were divided into endoscopic resection group (ER), local surgery group (LS) and radical surgery group (RS). The primary endpoint was recurrence free survival (RFS).Results  A total of 736 R-NETs patients were enrolled. For the controversial 1-2 cm tumor, there was no significant difference in the long-term RFS between the LS group and the ER group (P = 0.280), and the postoperative hospitalization days of the LS group was relatively short (median 2 days vs. 3 days, P < 0.001). Sensitivity analysis using propensity score matching (PSM) further confirmed these outcomes in postoperative hospitalization days (P < 0.001).Conclusion  For 1-2 cm R-NETs, recurrence events were rare in both treatment groups, and local surgery was associated with a shorter postoperative hospital stay.
SN  - 0179-1958
SN  - 1432-1262
ER  -