Peer-reviewedCC BYArquivos de gastroenterologia26 Oct 2026

PANCREATIC NEUROENDOCRINE TUMORS: CLINICOPATHOLOGICAL ANALYSIS AND POSTOPERATIVE SURVIVAL FOLLOWING SURGICAL RESECTION-A DECADE OF EXPERIENCE AT A TERTIARY UNIVERSITY HOSPITAL.

Mariana Martins Sanches Ferreira¹
Philipe Franco do Amaral Tafner¹
Martinho Antonio Gestic¹
Murillo Pimentel Utrini¹
Francisco Callejas-Neto¹
Everton Cazzo¹

¹Universidade Estadual de Campinas (UNICAMP), Faculdade de Ciências Médicas, Campinas, SP, Brasil.

Abstract

Background

Pancreatic neuroendocrine tumors (PNETs) are rare neoplasms of the digestive system, with variable prognoses and biological behaviors. Surgical resection remains the mainstay of treatment. Objective: To evaluate the clinicopathological characteristics and surgical outcomes of patients with PNETs who underwent resection at the Hospital de Clínicas, UNICAMP.Methods

This is a retrospective cohort study including 24 patients who underwent surgical resection between 2013 and 2023. Clinical, demographic, histopathological, and survival data were analyzed. The primary outcome was overall survival.Results

The mean age was 53.9 ± 14.4 years, with a predominance of female patients (66.7%). Most tumors were nonfunctioning (79.1%), with abdominal pain (79.2%) and weight loss (50%) being the most common symptoms. The surgical procedures performed were distal pancreatectomy (54.2%), pancreaticoduodenectomy (41.6%), and enucleation (4.2%). Histological classification revealed 62.5% grade 2 tumors, 33.3% grade 1, and 4.2% MiNEN. Mean overall survival was 70.4 ± 58 months. There was a trend toward longer survival in grade 1 tumors (98 ± 68.1 months) compared to grade 2 (59.1 ± 49.5 months; P=0.06). Postoperative mortality was 8.3%, associated with pancreaticoduodenectomy.Conclusion

Histological grading remains a key prognostic factor in PNETs. Surgical resection remains the cornerstone of treatment. Multicenter studies are necessary to validate these findings on a larger scale.

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Cite

BibTeX RIS

BibTeX

@article{ferreira2026pancreatic,
  title = {{PANCREATIC NEUROENDOCRINE TUMORS: CLINICOPATHOLOGICAL ANALYSIS AND POSTOPERATIVE SURVIVAL FOLLOWING SURGICAL RESECTION-A DECADE OF EXPERIENCE AT A TERTIARY UNIVERSITY HOSPITAL.}},
  author = {Mariana Martins Sanches Ferreira and Philipe Franco do Amaral Tafner and Martinho Antonio Gestic and Murillo Pimentel Utrini and Francisco Callejas-Neto and Everton Cazzo},
  journal = {Arquivos de gastroenterologia},
  year = {2026},
  month = oct,
  doi = {10.1590/s0004-2803.24612025-089},
  url = {https://europepmc.org/article/MED/42961246},
  note = {CC BY},
}

RIS

TY  - JOUR
TI  - PANCREATIC NEUROENDOCRINE TUMORS: CLINICOPATHOLOGICAL ANALYSIS AND POSTOPERATIVE SURVIVAL FOLLOWING SURGICAL RESECTION-A DECADE OF EXPERIENCE AT A TERTIARY UNIVERSITY HOSPITAL.
AU  - Mariana Martins Sanches Ferreira
AU  - Philipe Franco do Amaral Tafner
AU  - Martinho Antonio Gestic
AU  - Murillo Pimentel Utrini
AU  - Francisco Callejas-Neto
AU  - Everton Cazzo
PY  - 2026
DA  - 2026/10/26
JO  - Arquivos de gastroenterologia
DO  - 10.1590/s0004-2803.24612025-089
UR  - https://europepmc.org/article/MED/42961246
AB  - Background  Pancreatic neuroendocrine tumors (PNETs) are rare neoplasms of the digestive system, with variable prognoses and biological behaviors. Surgical resection remains the mainstay of treatment. Objective: To evaluate the clinicopathological characteristics and surgical outcomes of patients with PNETs who underwent resection at the Hospital de Clínicas, UNICAMP.Methods  This is a retrospective cohort study including 24 patients who underwent surgical resection between 2013 and 2023. Clinical, demographic, histopathological, and survival data were analyzed. The primary outcome was overall survival.Results  The mean age was 53.9 ± 14.4 years, with a predominance of female patients (66.7%). Most tumors were nonfunctioning (79.1%), with abdominal pain (79.2%) and weight loss (50%) being the most common symptoms. The surgical procedures performed were distal pancreatectomy (54.2%), pancreaticoduodenectomy (41.6%), and enucleation (4.2%). Histological classification revealed 62.5% grade 2 tumors, 33.3% grade 1, and 4.2% MiNEN. Mean overall survival was 70.4 ± 58 months. There was a trend toward longer survival in grade 1 tumors (98 ± 68.1 months) compared to grade 2 (59.1 ± 49.5 months; P=0.06). Postoperative mortality was 8.3%, associated with pancreaticoduodenectomy.Conclusion  Histological grading remains a key prognostic factor in PNETs. Surgical resection remains the cornerstone of treatment. Multicenter studies are necessary to validate these findings on a larger scale.
SN  - 0004-2803
SN  - 1678-4219
ER  -

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