Skip to content
DraconiticResearch
Search Sources API
197,785 studies31 sourcesUpdated 47 min ago
Peer-reviewedCC BYBMC Endocrine Disorders

Patient-reported outcomes between patients with young-onset type 2 and type 1 diabetes mellitus: results from the Taiwan diabetes registry

  • Hsuan-Wei Lin1
  • Fu-Shun Ko2
  • Yen-Po Yeh3
  • Jui-Hsiang Li4
  • Chien-Ning Huang5
  • Chih-Yiu Tsai6
  • Wayne Huey-Herng Sheu7
  • Lee-Ming Chuang8
  • Chen-Chang Yang9
  • Chii-Min Hwu2
9 affiliations
  1. 1Department of Internal Medicine, Min-Sheng General Hospital
  2. 2Section of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital
  3. 3Changhua County Public Health Bureau
  4. 4Division of Endocrinology and Metabolism, Department of Internal Medicine, Taoyuan General Hospital, Ministry of Health and Welfare
  5. 5Institute of Medicine, Chung Shan Medical University
  6. 6Division of Endocrinology and Metabolism, Chang Gung Memorial Hospital
  7. 7Distinguished Investigator and Vice President, National Health Research Institute
  8. 8Division of Endocrinology & Metabolism, Department of Internal Medicine, National Taiwan University Hospital
  9. 9Institute of Public Health, National Yang-Ming Chiao Tung University School of Medicine
Read full textDOICite

Abstract

Background Young-onset type 2 diabetes (YOD) is associated with earlier microvascular complications and higher mortality compared to type 1 diabetes (T1D). However, its impact on health-related quality of life (HRQoL) remains unclear. Specific aims To compare HRQoL between adults with YOD and T1D in Taiwan, accounting for demographic and lifestyle factors, comorbidities, and diabetes goal attainment. Methods A cross-sectional analysis was conducted using data from the Taiwan Diabetes Registry (October 2015–August 2018). HRQoL was assessed at enrollment with the EuroQol EQ-5D instrument. Differences in visual analog scale (VAS) scores and ratios of disutility scores derived from EQ-5D index values were estimated using multivariable linear regression and marginalized two-part regression models. Diabetes-specific HRQoL was assessed using the Diabetes-Related Distress Questionnaire (DRDQ). Results A total of 1,442 adults were included (603 YOD, 839 T1D). YOD patients had lower VAS scores than T1D patients (71.5 vs. 75.6, p < 0.0001), and the difference remained statistically significant after adjustment. Stratified analysis revealed that this difference was most pronounced among patients within the first five years of diagnosis. Disutility scores did not differ significantly. Compared with T1D patients, YOD patients reported lower levels of diabetes-related distress on the DRDQ. Conclusions YOD is associated with modestly lower generic HRQoL, particularly within the first five years of diagnosis, whereas T1D patients reported greater diabetes-related distress. These findings highlight distinct challenges in younger-onset diabetes and underscore the need for longitudinal research to clarify their clinical relevance. Clinical trial number Not applicable.

Related

  1. Effects of Metformin on Clinical Outcomes After Acute Ischemic Stroke in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis
    Ting-Yen Chen, Yu-Chi Su, Yu-Ching Lin
    Journal of clinical medicinePeer-reviewedCC BYFull textGeneral medicineEurope PMC
  2. The Relationship Between Intuitive Eating, Diabetes-Related Health Knowledge, and Psychological Health Outcomes in Patients with Type 2 Diabetes Mellitus.
    Heba Mahmoud Mahmoud Mohamed, Marwa Fouad Mahmoud, Mira Naguib Abdelrazek +5
    Healthcare (Basel, Switzerland)Peer-reviewedCC BYFull textEndocrinology & metabolismEurope PMC
  3. Response to the Letter to the Editor: &quot;Younger Age is Associated with Treatment and Complication Outcomes Among Type 2 Diabetes Mellitus Patients in Kigali UniversityTeaching Hospital&rdquo; [Response to letter]
    Alagbonsi AI, Kagina APN, Ingabire D +6
    Diabetes, Metabolic Syndrome and ObesityPeer-reviewedCC BYFull textEndocrinology & metabolismDOAJ
  4. Real-World Renal and Metabolic Outcomes of SGLT-2 Inhibitor Therapy in Patients with Type 2 Diabetes Mellitus
    Öykü Ünsal, Hüseyin Döngelli, Mehmet Çağrı Ünal +3
    Journal of Clinical MedicinePeer-reviewedCC BY 4.0Full textEndocrinology & metabolismCrossrefEurope PMC
  5. A Comparative Exploratory Study of Cognitive and Functional Outcomes by Sex and Age in Patients With Type 2 Diabetes Mellitus and Atrial Fibrillation
    MARIUS MILITARU, DANIEL FLORIN LIGHEZAN, CRISTINA TUDORAN +3
    In VivoPeer-reviewedCC BY-NC-ND 4.0Full textPsychiatry & mental healthPMC

Cite

BibTeXRIS
BibTeX
@article{lin2026patientreported,
  title = {{Patient-reported outcomes between patients with young-onset type 2 and type 1 diabetes mellitus: results from the Taiwan diabetes registry}},
  author = {Hsuan-Wei Lin and Fu-Shun Ko and Yen-Po Yeh and Jui-Hsiang Li and Chien-Ning Huang and Chih-Yiu Tsai and Wayne Huey-Herng Sheu and Lee-Ming Chuang and Chen-Chang Yang and Chii-Min Hwu},
  journal = {BMC Endocrine Disorders},
  year = {2026},
  month = aug,
  doi = {10.1186/s12902-026-02461-1},
  url = {https://doi.org/10.1186/s12902-026-02461-1},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Patient-reported outcomes between patients with young-onset type 2 and type 1 diabetes mellitus: results from the Taiwan diabetes registry
AU  - Hsuan-Wei Lin
AU  - Fu-Shun Ko
AU  - Yen-Po Yeh
AU  - Jui-Hsiang Li
AU  - Chien-Ning Huang
AU  - Chih-Yiu Tsai
AU  - Wayne Huey-Herng Sheu
AU  - Lee-Ming Chuang
AU  - Chen-Chang Yang
AU  - Chii-Min Hwu
PY  - 2026
DA  - 2026/08/01
JO  - BMC Endocrine Disorders
DO  - 10.1186/s12902-026-02461-1
UR  - https://doi.org/10.1186/s12902-026-02461-1
AB  - Background Young-onset type 2 diabetes (YOD) is associated with earlier microvascular complications and higher mortality compared to type 1 diabetes (T1D). However, its impact on health-related quality of life (HRQoL) remains unclear. Specific aims To compare HRQoL between adults with YOD and T1D in Taiwan, accounting for demographic and lifestyle factors, comorbidities, and diabetes goal attainment. Methods A cross-sectional analysis was conducted using data from the Taiwan Diabetes Registry (October 2015–August 2018). HRQoL was assessed at enrollment with the EuroQol EQ-5D instrument. Differences in visual analog scale (VAS) scores and ratios of disutility scores derived from EQ-5D index values were estimated using multivariable linear regression and marginalized two-part regression models. Diabetes-specific HRQoL was assessed using the Diabetes-Related Distress Questionnaire (DRDQ). Results A total of 1,442 adults were included (603 YOD, 839 T1D). YOD patients had lower VAS scores than T1D patients (71.5 vs. 75.6, p < 0.0001), and the difference remained statistically significant after adjustment. Stratified analysis revealed that this difference was most pronounced among patients within the first five years of diagnosis. Disutility scores did not differ significantly. Compared with T1D patients, YOD patients reported lower levels of diabetes-related distress on the DRDQ. Conclusions YOD is associated with modestly lower generic HRQoL, particularly within the first five years of diagnosis, whereas T1D patients reported greater diabetes-related distress. These findings highlight distinct challenges in younger-onset diabetes and underscore the need for longitudinal research to clarify their clinical relevance. Clinical trial number Not applicable.
SN  - 1472-6823
ER  -