Skip to content
DraconiticResearch
Search Sources API
223,221 studies31 sourcesUpdated 53 min ago
Peer-reviewedCC BY-NCPulmonary circulation

Thymic Stromal Lymphopoietin Promotes Proliferation and Contractility of Human Pulmonary Artery Smooth Muscle.

  • Michael Thompson1,2
  • Martin Helan3,4,5
  • Li Drake1
  • Benjamin Roos1
  • Christina M Pabelick1,2
  • Y S Prakash1,2
5 affiliations
  1. 1Department of Anesthesiology and Perioperative Medicine Mayo Clinic Rochester Minnesota USA.
  2. 2Department of Physiology and Biomedical Engineering Mayo Clinic Rochester Minnesota USA.
  3. 3Department of Anesthesiology and Intensive Care Brno University Brno Czech Republic.
  4. 4Department of Neurosurgery Brno University Brno Czech Republic.
  5. 5Intensive Care Research Brno University Brno Czech Republic.
Read full textPDFDOICite

Abstract

Hypoxia is a well-recognized risk factor in several pulmonary vascular diseases, including pulmonary hypertension (PH). Furthermore, hypoxia-associated inflammatory changes enhance the structural and functional changes in the pulmonary artery (PA) of PH patients. Understanding the mechanisms that link hypoxia and inflammation, particularly early in disease, is key to the development of novel therapeutic avenues for PH. Thymic stromal lymphopoietin (TSLP) is an "early" inflammatory mediator thought to be critical in diseases such as asthma, chronic obstructive pulmonary disease, and atopic dermatitis. TSLP has canonical effects on the immune system, but can also have non-canonical effects on resident lung cells, for example, airway smooth muscle. Currently, the expression and role of TSLP in the PA are unknown. We hypothesized that locally produced TSLP potentiates the effects of hypoxia in PA remodeling and contractility relevant to PH. Experiments in human PA endothelial cells (PAECs) and smooth muscle cells (PASMCs) found PAECs to be a larger source of TSLP, which targets PASMCs to enhance intracellular Ca2+ responses and contractility to vasoconstrictor agonists, as well as cell proliferation and extracellular matrix deposition, acting via a number of signaling cascades including Stat3 and PI3/Akt. Hypoxia, acting via HIF1α, enhanced PAEC production of TSLP and promoted TSLP effects on PASMCs. Interestingly, TSLP per se enhanced HIF1α. Overall, these novel data highlight a role for TSLP in hypoxia effects on the PA, and thus relevance for inflammation in PH.

Related

  1. M2 type tumor-associated macrophage-derived CCL-18 promotes glioma cell proliferation but does not mediates glioma recurrence after radiotherapy
    Jiangpeng Fan, Yufei Mao, Li Liu +7
    ISciencePeer-reviewedCC BY-NC-NDFull textHuman geneticsEurope PMCCrossref
  2. A Tumor-Pituitary-Stromal Axis Promotes Colorectal Cancer Progression
    W. Li, S. Wang, H. Wu +9
    bioRxivPreprintAll rights reservedFull textOncologybioRxiv
  3. Localized transplantation of periodontal ligament-derived mesenchymal stromal cell sheets promotes mandibular wound healing in zoledronate-treated beagle dogs
    Nobuyuki Kaibuchi, Takanori Iwata, Masayuki Yamato +7
    Scientific ReportsPeer-reviewedCC BY 4.0Full textOncologyCrossref
  4. Pharmacological TLR4 Activation Promotes Hepatocyte Proliferation and Liver Repair Through Coordinated IL-6 and TCDCA Signaling.
    Xinlu Yu, Haoxin Ma, Chao Wang +9
    BiologyPeer-reviewedCC BYFull textGeneral medicineEurope PMC
  5. Dio2+Il11+ fibroblasts constitute a local stromal-endocrine niche that promotes intestinal stem cell regeneration after immune-mediated injury
    Pavan Reddy, Takashi Ikeda, Akira Yamamoto +13
    Research SquarePreprintCC BY 4.0Full textGeneral medicinePMC

Cite

BibTeXRIS
BibTeX
@article{thompson2026thymic,
  title = {{Thymic Stromal Lymphopoietin Promotes Proliferation and Contractility of Human Pulmonary Artery Smooth Muscle.}},
  author = {Michael Thompson and Martin Helan and Li Drake and Benjamin Roos and Christina M Pabelick and Y S Prakash},
  journal = {Pulmonary circulation},
  year = {2026},
  month = oct,
  doi = {10.1002/pul2.70450},
  url = {https://europepmc.org/article/MED/42999736},
  note = {CC BY-NC},
}
RIS
TY  - JOUR
TI  - Thymic Stromal Lymphopoietin Promotes Proliferation and Contractility of Human Pulmonary Artery Smooth Muscle.
AU  - Michael Thompson
AU  - Martin Helan
AU  - Li Drake
AU  - Benjamin Roos
AU  - Christina M Pabelick
AU  - Y S Prakash
PY  - 2026
DA  - 2026/10/01
JO  - Pulmonary circulation
DO  - 10.1002/pul2.70450
UR  - https://europepmc.org/article/MED/42999736
AB  - Hypoxia is a well-recognized risk factor in several pulmonary vascular diseases, including pulmonary hypertension (PH). Furthermore, hypoxia-associated inflammatory changes enhance the structural and functional changes in the pulmonary artery (PA) of PH patients. Understanding the mechanisms that link hypoxia and inflammation, particularly early in disease, is key to the development of novel therapeutic avenues for PH. Thymic stromal lymphopoietin (TSLP) is an "early" inflammatory mediator thought to be critical in diseases such as asthma, chronic obstructive pulmonary disease, and atopic dermatitis. TSLP has canonical effects on the immune system, but can also have non-canonical effects on resident lung cells, for example, airway smooth muscle. Currently, the expression and role of TSLP in the PA are unknown. We hypothesized that locally produced TSLP potentiates the effects of hypoxia in PA remodeling and contractility relevant to PH. Experiments in human PA endothelial cells (PAECs) and smooth muscle cells (PASMCs) found PAECs to be a larger source of TSLP, which targets PASMCs to enhance intracellular Ca2+ responses and contractility to vasoconstrictor agonists, as well as cell proliferation and extracellular matrix deposition, acting via a number of signaling cascades including Stat3 and PI3/Akt. Hypoxia, acting via HIF1α, enhanced PAEC production of TSLP and promoted TSLP effects on PASMCs. Interestingly, TSLP per se enhanced HIF1α. Overall, these novel data highlight a role for TSLP in hypoxia effects on the PA, and thus relevance for inflammation in PH.
SN  - 2045-8932
SN  - 2045-8940
ER  -