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Peer-reviewedCC BYCureus

Drug-Disease Interactions Causing Hemorrhagic Cardiac Tamponade

  • Brian Torres-Mercado1
  • Xavier Delgado-Lopez1
  • Joseph Maldonado-Suarez1
  • David R Bermudez Nunez1
  • Juan F Rodriguez Acosta1
  1. 1Cardiology, Mayagüez Medical Center, Mayagüez, PRI
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Abstract

Hemorrhagic tamponade in severe hypothyroidism is an uncommon presentation that warrants evaluation for superimposed pathology. We present the case of a 57-year-old man with nonischemic cardiomyopathy, chronic amiodarone therapy, and atrial fibrillation on apixaban who developed advanced myxedema, complicated by a large hemorrhagic pericardial effusion and cardiac tamponade. This case highlights a rare but life-threatening convergence of amiodarone-induced severe hypothyroidism and potentiated anticoagulation, culminating in hemorrhagic tamponade. Recognition of drug-disease interactions is critical in anticoagulated patients with endocrine dysfunction who present with rapidly recurrent pericardial effusion.

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Cite

BibTeXRIS
BibTeX
@article{torresmercado2026drugdisease,
  title = {{Drug-Disease Interactions Causing Hemorrhagic Cardiac Tamponade}},
  author = {Brian Torres-Mercado and Xavier Delgado-Lopez and Joseph Maldonado-Suarez and David R Bermudez Nunez and Juan F Rodriguez Acosta},
  journal = {Cureus},
  year = {2026},
  month = sep,
  doi = {10.7759/cureus.117237},
  url = {https://europepmc.org/article/PMC/PMC13722135},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Drug-Disease Interactions Causing Hemorrhagic Cardiac Tamponade
AU  - Brian Torres-Mercado
AU  - Xavier Delgado-Lopez
AU  - Joseph Maldonado-Suarez
AU  - David R Bermudez Nunez
AU  - Juan F Rodriguez Acosta
PY  - 2026
DA  - 2026/09/30
JO  - Cureus
DO  - 10.7759/cureus.117237
UR  - https://europepmc.org/article/PMC/PMC13722135
AB  - Hemorrhagic tamponade in severe hypothyroidism is an uncommon presentation that warrants evaluation for superimposed pathology. We present the case of a 57-year-old man with nonischemic cardiomyopathy, chronic amiodarone therapy, and atrial fibrillation on apixaban who developed advanced myxedema, complicated by a large hemorrhagic pericardial effusion and cardiac tamponade. This case highlights a rare but life-threatening convergence of amiodarone-induced severe hypothyroidism and potentiated anticoagulation, culminating in hemorrhagic tamponade. Recognition of drug-disease interactions is critical in anticoagulated patients with endocrine dysfunction who present with rapidly recurrent pericardial effusion.
SN  - 2168-8184
ER  -