Efficacy of intravenous lipid emulsion in enhancing the recovery of spinal anesthesia: An exploratory double-blinded, randomized controlled study.
4 affiliations
- 1Department of Anaesthesiology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
- 2Department of Urology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
- 3Department of Anaesthesiology, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India.
- 4Department of Physiology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
Abstract
Purpose
Prolonged motor recovery associated with spinal anesthesia (SA) limits its utility in day-case surgery. We evaluated the efficacy of intravenous lipid emulsion (ILE) in accelerating recovery from sensory-motor blockade in patients undergoing day-case surgery under SA.Methods
In a double-blinded randomized study, 60 adult patients who underwent short surgical procedures under SA were randomly allocated to receive either ILE (1.5 mL/kg bolus, followed by 0.25 mL/kg/min infusion) over 30 minutes (test group) or normal saline (control group) in the immediate postoperative period. The primary objective was the time to recovery of sensory and motor blockade. The study was registered in the clinical trial registry of India CTRI/2021/11/038080 dated 11/6/2021 (www.ctri.nic.in).Results
Demographic characteristics (age, gender, American Society of Anaesthesiologists physical status grading, height, and weight) were comparable between the two groups. The recovery of sensory (200.6 ± 19.8 min versus 237.1 ± 17.9 min, P ≤ 0.001, absolute standard difference: --1.9 (95% confidence interval [CI]: --2.5 to --1.3) and motor block (157.8 ± 13.1 min versus 193.6 ± 23.0 min, P ≤ 0.001, absolute standard difference: --1.9 (95% CI: --2.5 to --1.3) were significantly faster in the test group compared to the control group.Conclusions
This study demonstrates that 20% ILE accelerates recovery from SA (both sensory and motor blocks), highlighting its potential utility in day-case surgery. Further trials on a larger sample size are required to validate the same.Trial Registration: CTRI/2021/11/038080 dated 11/6/2021.
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BibTeX
@article{kumar2026efficacy,
title = {{Efficacy of intravenous lipid emulsion in enhancing the recovery of spinal anesthesia: An exploratory double-blinded, randomized controlled study.}},
author = {Karthikeyan Suresh Kumar and Praveen Talawar and Bhavna Gupta and Ankur Mittal and Ashutosh Kaushal and Ruma Thakuria and Nikita Choudhary and M Sandhya and Toshi Gupta},
journal = {Saudi journal of anaesthesia},
year = {2026},
month = oct,
doi = {10.4103/sja.sja_456_26},
url = {https://europepmc.org/article/MED/42960328},
note = {CC BY-NC-SA},
}
RIS
TY - JOUR
TI - Efficacy of intravenous lipid emulsion in enhancing the recovery of spinal anesthesia: An exploratory double-blinded, randomized controlled study.
AU - Karthikeyan Suresh Kumar
AU - Praveen Talawar
AU - Bhavna Gupta
AU - Ankur Mittal
AU - Ashutosh Kaushal
AU - Ruma Thakuria
AU - Nikita Choudhary
AU - M Sandhya
AU - Toshi Gupta
PY - 2026
DA - 2026/10/01
JO - Saudi journal of anaesthesia
DO - 10.4103/sja.sja_456_26
UR - https://europepmc.org/article/MED/42960328
AB - Purpose Prolonged motor recovery associated with spinal anesthesia (SA) limits its utility in day-case surgery. We evaluated the efficacy of intravenous lipid emulsion (ILE) in accelerating recovery from sensory-motor blockade in patients undergoing day-case surgery under SA.Methods In a double-blinded randomized study, 60 adult patients who underwent short surgical procedures under SA were randomly allocated to receive either ILE (1.5 mL/kg bolus, followed by 0.25 mL/kg/min infusion) over 30 minutes (test group) or normal saline (control group) in the immediate postoperative period. The primary objective was the time to recovery of sensory and motor blockade. The study was registered in the clinical trial registry of India CTRI/2021/11/038080 dated 11/6/2021 (www.ctri.nic.in).Results Demographic characteristics (age, gender, American Society of Anaesthesiologists physical status grading, height, and weight) were comparable between the two groups. The recovery of sensory (200.6 ± 19.8 min versus 237.1 ± 17.9 min, P ≤ 0.001, absolute standard difference: --1.9 (95% confidence interval [CI]: --2.5 to --1.3) and motor block (157.8 ± 13.1 min versus 193.6 ± 23.0 min, P ≤ 0.001, absolute standard difference: --1.9 (95% CI: --2.5 to --1.3) were significantly faster in the test group compared to the control group.Conclusions This study demonstrates that 20% ILE accelerates recovery from SA (both sensory and motor blocks), highlighting its potential utility in day-case surgery. Further trials on a larger sample size are required to validate the same.Trial Registration: CTRI/2021/11/038080 dated 11/6/2021.
SN - 1658-354X
SN - 0975-3125
ER -