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Peer-reviewedCC BY-NCScience Advances

Programmable and selective silencing of oncogenic fusion transcripts by CRISPR-Cas13b via breakpoint sequence recognition

  • Wenxin Hu (胡文欣)1,2,3
  • Honglin Chen (陈竑霖)1,2,3
  • Steven He4,5
  • Joshua M. L. Casan1,2,3
  • Carolyn Shembrey1,2
  • Sharon Li6,7
  • Lauren M. Brown4,5
  • Andrea Zhao4,5
  • Lynda Truong8,9
  • Isabella Buchner8
  • Dane Vassiliadis1,2,3
  • Timothy P. Hughes10,11
9 more authors
  • Deborah L. White10,11
  • Catherine L. Carmichael8,9
  • Antoine De Weck4,5
  • Ilia Voskoboinik1,2
  • Quentin Gouil6,7
  • Joseph A. Trapani1,2
  • Paul G. Ekert1,2,4,5,12
  • Teresa Sadras1,2,6,7
  • Mohamed Fareh1,2,3
12 affiliations
  1. 1Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.
  2. 2Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC 3052, Australia.
  3. 3Collaborative Centre for Genomic Cancer Medicine, University of Melbourne, Parkville, Victoria, Australia.
  4. 4Children’s Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, NSW Australia 2052.
  5. 5School of Women’s and Children’s Health, UNSW Sydney, Sydney, NSW, Australia.
  6. 6Olivia Newton-John Cancer Research Institute, Heidelberg, Melbourne, Australia.
  7. 7School of Cancer Medicine, La Trobe University, Bundoora, Melbourne, Australia.
  8. 8Centre for Cancer Research, Hudson Institute of Medical Research, VIC Australia 3168.
  9. 9Monash University, Clayton, VIC Australia 380010.
  10. 10Precision Cancer Medicine Theme. South Australian Health and Medical Research Institute (SAHMRI). Adelaide SA.
  11. 11Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA 5005, Australia.
  12. 12Murdoch Children’s Research Institute, Royal Children’s Hospital, 50 Flemington Rd, Parkville, Melbourne, 3052, Australia.
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Cite

BibTeXRIS
BibTeX
@article{胡文欣2026programmable,
  title = {{Programmable and selective silencing of oncogenic fusion transcripts by CRISPR-Cas13b via breakpoint sequence recognition}},
  author = {Wenxin Hu (胡文欣) and Honglin Chen (陈竑霖) and Steven He and Joshua M. L. Casan and Carolyn Shembrey and Sharon Li and Lauren M. Brown and Andrea Zhao and Lynda Truong and Isabella Buchner and Dane Vassiliadis and Timothy P. Hughes and Deborah L. White and Catherine L. Carmichael and Antoine De Weck and Ilia Voskoboinik and Quentin Gouil and Joseph A. Trapani and Paul G. Ekert and Teresa Sadras and Mohamed Fareh},
  journal = {Science Advances},
  year = {2026},
  month = oct,
  doi = {10.1126/sciadv.ady0296},
  url = {https://www.science.org/doi/10.1126/sciadv.ady0296},
  note = {CC BY-NC},
}
RIS
TY  - JOUR
TI  - Programmable and selective silencing of oncogenic fusion transcripts by CRISPR-Cas13b via breakpoint sequence recognition
AU  - Wenxin Hu (胡文欣)
AU  - Honglin Chen (陈竑霖)
AU  - Steven He
AU  - Joshua M. L. Casan
AU  - Carolyn Shembrey
AU  - Sharon Li
AU  - Lauren M. Brown
AU  - Andrea Zhao
AU  - Lynda Truong
AU  - Isabella Buchner
AU  - Dane Vassiliadis
AU  - Timothy P. Hughes
AU  - Deborah L. White
AU  - Catherine L. Carmichael
AU  - Antoine De Weck
AU  - Ilia Voskoboinik
AU  - Quentin Gouil
AU  - Joseph A. Trapani
AU  - Paul G. Ekert
AU  - Teresa Sadras
AU  - Mohamed Fareh
PY  - 2026
DA  - 2026/10/16
JO  - Science Advances
DO  - 10.1126/sciadv.ady0296
UR  - https://www.science.org/doi/10.1126/sciadv.ady0296
SN  - 2375-2548
ER  -