Cytotoxic Lesion of the Corpus Callosum in a Patient with Acute-on-chronic Lithium Toxicity

Abstract

A 30-year-old woman with history of bipolar disorder presented to the emergency department with impaired consciousness and myoclonus following regular lithium treatment. Brain magnetic resonance imaging revealed a hyperintense lesion in the splenium of the corpus callosum, consistent with cytotoxic lesions of the corpus callosum (CLOCCs). Serum lithium levels were markedly elevated (3.54 mmol/L), and acute-on-chronic lithium toxicity was diagnosed. Hemodialysis and supportive care resulted in clinical and radiological recovery. This case highlights that CLOCCs may serve as important neuroimaging evidence of lithium toxicity and may support an early diagnosis and treatment, especially in patients with long-term lithium use.

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BibTeX RIS

BibTeX

@article{miura2026cytotoxic,
  title = {{Cytotoxic Lesion of the Corpus Callosum in a Patient with Acute-on-chronic Lithium Toxicity}},
  author = {Takeshi Miura and Teruki Kuroshita and Yosui Higuchi and Minori Ohno and Ayano Notsuyu and Takuya Fushino and Takahiro Ono and Natsumi Tomisawa and Keishun Boku and Yuki Enomoto and Yoshiaki Inoue},
  journal = {Internal Medicine},
  year = {2026},
  month = sep,
  doi = {10.2169/internalmedicine.6327-25},
  url = {https://www.jstage.jst.go.jp/article/internalmedicine/65/17/65_6327-25/_article},
  note = {CC BY-NC-ND},
}

RIS

TY  - JOUR
TI  - Cytotoxic Lesion of the Corpus Callosum in a Patient with Acute-on-chronic Lithium Toxicity
AU  - Takeshi Miura
AU  - Teruki Kuroshita
AU  - Yosui Higuchi
AU  - Minori Ohno
AU  - Ayano Notsuyu
AU  - Takuya Fushino
AU  - Takahiro Ono
AU  - Natsumi Tomisawa
AU  - Keishun Boku
AU  - Yuki Enomoto
AU  - Yoshiaki Inoue
PY  - 2026
DA  - 2026/09/01
JO  - Internal Medicine
DO  - 10.2169/internalmedicine.6327-25
UR  - https://www.jstage.jst.go.jp/article/internalmedicine/65/17/65_6327-25/_article
AB  - A 30-year-old woman with history of bipolar disorder presented to the emergency department with impaired consciousness and myoclonus following regular lithium treatment. Brain magnetic resonance imaging revealed a hyperintense lesion in the splenium of the corpus callosum, consistent with cytotoxic lesions of the corpus callosum (CLOCCs). Serum lithium levels were markedly elevated (3.54 mmol/L), and acute-on-chronic lithium toxicity was diagnosed. Hemodialysis and supportive care resulted in clinical and radiological recovery. This case highlights that CLOCCs may serve as important neuroimaging evidence of lithium toxicity and may support an early diagnosis and treatment, especially in patients with long-term lithium use.
SN  - 1349-7235
SN  - 0918-2918
ER  -

Abstract

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