Clinical and imaging characterization of ocular toxoplasmosis in a Central-West Brazilian population.
- 1Universidade Federal do Mato Grosso do Sul, Três Lagoas, MS, Brazil.
- 2Department of Dermatological, Infectious and Parasitic Diseases, Faculdade de Medicina de São José do Rio Preto, FAMERP Toxoplasma Research Group, Avenida Brigadeiro Faria Lima, 5416, São José do Rio Preto, SP, 15090-000, Brazil.
- 3Department of Dermatological, Infectious and Parasitic Diseases, Faculdade de Medicina de São José do Rio Preto, FAMERP Toxoplasma Research Group, Avenida Brigadeiro Faria Lima, 5416, São José do Rio Preto, SP, 15090-000, Brazil. [email protected].
Abstract
Objective
To evaluate and characterize patients with presumed ocular toxoplasmosis using combined clinical and serological approaches in the municipality of Três Lagoas, Mato Grosso do Sul, Brazil.Methods
This cross-sectional quantitative study included 85 patients with presumed Toxoplasma gondii related retinochoroiditis referred from the public healthcare system. Participants underwent ophthalmologic examination and serological testing for anti-T. gondii IgG and IgM antibodies. Patients were classified into control (G1), active lesion (G2), and cicatricial lesion (G3) groups.Results
Overall, 76.5% of patients were positive for anti-T. gondii IgG, while 3.5% were positive for IgM. Most patients with cicatricial lesions (G3) were IgG-positive (31/33). In contrast, IgM positivity was restricted to a small subset of patients (3/13) with active lesions (G2). Ophthalmologic evaluation demonstrated that unilateral disease predominated (78.2%), with lesions mainly located in the posterior pole (52.8%). Morphologically, round-to-ovoid lesions were most frequent (60.0%), followed by amoeboid (16.0%), placoid (8.0%), and wedge-shaped and punctate (4.0% each) patterns. Mean lesion size among evaluable eyes was 16.2 mm².Conclusion
The analyses provide data that contribute to the understanding of the clinical characteristics of the disease, ocular behavior, and serological findings. Consequently, preventive measures may be implemented, reducing risk factors and improving patients' quality of life.
Related
- Normal Values for the Two-Point Discrimination Test for Fingers in the Brazilian Population: Cross-Sectional Study.
- GERBase: an online tool for high-resolution HLA allele and haplotype frequencies and linkage disequilibrium analysis in a Brazilian population.
- New Record of Raillietiella furcocerca (Pentastomida: Raillietiellidae) in Bothrops atrox from the Brazilian Amazon: Morphological Characterization and Infection Sites
- High-resolution characterization of classical and non-classical HLA diversity reveals important admixture in Brazilian indigenous.
- A Novel Brazilian Isolate Expands the Genomic and Phenotypic Characterization of Chlorovirus americanus
BibTeX
@article{marques2026clinical,
title = {{Clinical and imaging characterization of ocular toxoplasmosis in a Central-West Brazilian population.}},
author = {Alexsandra Passarelli Giabardo Marques and Luiza Roschel Zaunrith and Danilo Donizete da Silva and Aparecida Perpétuo Silveira Carvalho and Fernando Henrique Antunes Murata and Rubens Camargo Siqueira and Lucas Gazarini and Edis Belini Júnior and Julie Massayo Maeda Oda and Christiane Maria Ayo and Luiz Carlos de Mattos and Cinara Cássia Brandão},
journal = {International ophthalmology},
year = {2026},
month = oct,
doi = {10.1007/s10792-026-04302-5},
url = {https://europepmc.org/article/MED/42891856},
note = {CC BY},
}
RIS
TY - JOUR
TI - Clinical and imaging characterization of ocular toxoplasmosis in a Central-West Brazilian population.
AU - Alexsandra Passarelli Giabardo Marques
AU - Luiza Roschel Zaunrith
AU - Danilo Donizete da Silva
AU - Aparecida Perpétuo Silveira Carvalho
AU - Fernando Henrique Antunes Murata
AU - Rubens Camargo Siqueira
AU - Lucas Gazarini
AU - Edis Belini Júnior
AU - Julie Massayo Maeda Oda
AU - Christiane Maria Ayo
AU - Luiz Carlos de Mattos
AU - Cinara Cássia Brandão
PY - 2026
DA - 2026/10/17
JO - International ophthalmology
DO - 10.1007/s10792-026-04302-5
UR - https://europepmc.org/article/MED/42891856
AB - Objective To evaluate and characterize patients with presumed ocular toxoplasmosis using combined clinical and serological approaches in the municipality of Três Lagoas, Mato Grosso do Sul, Brazil.Methods This cross-sectional quantitative study included 85 patients with presumed Toxoplasma gondii related retinochoroiditis referred from the public healthcare system. Participants underwent ophthalmologic examination and serological testing for anti-T. gondii IgG and IgM antibodies. Patients were classified into control (G1), active lesion (G2), and cicatricial lesion (G3) groups.Results Overall, 76.5% of patients were positive for anti-T. gondii IgG, while 3.5% were positive for IgM. Most patients with cicatricial lesions (G3) were IgG-positive (31/33). In contrast, IgM positivity was restricted to a small subset of patients (3/13) with active lesions (G2). Ophthalmologic evaluation demonstrated that unilateral disease predominated (78.2%), with lesions mainly located in the posterior pole (52.8%). Morphologically, round-to-ovoid lesions were most frequent (60.0%), followed by amoeboid (16.0%), placoid (8.0%), and wedge-shaped and punctate (4.0% each) patterns. Mean lesion size among evaluable eyes was 16.2 mm².Conclusion The analyses provide data that contribute to the understanding of the clinical characteristics of the disease, ocular behavior, and serological findings. Consequently, preventive measures may be implemented, reducing risk factors and improving patients' quality of life.
SN - 0165-5701
SN - 1573-2630
ER -