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Peer-reviewedCC BY 4.0International Journal of Molecular Sciences

Stem Cell and Exosome Treatment for Organ Health and Longevity

  • Chadwick Prodromos1
  • Ruby Del Villar1
  • Andrew Striegel1
  • Gerard Pena1
  • Rohan Dixit1
  • Amy Xu1
  1. 1The Prodromos Stem Cell Institute, 1714 Milwaukee Ave., Glenview, IL 60025, USA
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Abstract

Aging is associated with inflammation and is the greatest risk factor for chronic disease. Mesenchymal stem cells (MSCs) and exosomes have anti-inflammatory, pro-healing, and immunomodulatory effects that make them appealing candidates to reverse tissue and organ aging, improve overall organ function, and promote longevity. We hypothesized that treatment with MSCs and/or exosomes would improve the function of healthy mammalian organ systems and tissues, extend lifespan, and that treatment with stem cells from younger animals would have a greater rejuvenative effect than those from older animals. Through a review of the PubMed-indexed scientific literature, we sought to determine whether there is sound preclinical and/or clinical evidence to support these hypotheses. 34 preclinical studies were chosen as they demonstrated that stem cells and/or exosomes can restore bone density, improve muscle strength, significantly rejuvenate multiple organ systems, and increase longevity. Stem cell treatment appears to increase longevity, and both stem cell and exosome treatments are effective in rejuvenating and improving tissue and organ function in mammalian systems. Stem cells can extend overall mammalian lifespan. Transplantation of bone-marrow derived mesenchymal stem cells can restore bone density in mice. MSCs have a regenerative effect on aging muscles in mice. Both stem cells and exosomes have a rejuvenative effect on animal organ systems. Stem cells and exosomes improve organ function in the absence of pathological states.

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Cite

BibTeXRIS
BibTeX
@article{prodromos2026stem,
  title = {{Stem Cell and Exosome Treatment for Organ Health and Longevity}},
  author = {Chadwick Prodromos and Ruby Del Villar and Andrew Striegel and Gerard Pena and Rohan Dixit and Amy Xu},
  journal = {International Journal of Molecular Sciences},
  year = {2026},
  month = oct,
  doi = {10.3390/ijms27209174},
  url = {https://www.mdpi.com/1422-0067/27/20/9174},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Stem Cell and Exosome Treatment for Organ Health and Longevity
AU  - Chadwick Prodromos
AU  - Ruby Del Villar
AU  - Andrew Striegel
AU  - Gerard Pena
AU  - Rohan Dixit
AU  - Amy Xu
PY  - 2026
DA  - 2026/10/16
JO  - International Journal of Molecular Sciences
DO  - 10.3390/ijms27209174
UR  - https://www.mdpi.com/1422-0067/27/20/9174
AB  - Aging is associated with inflammation and is the greatest risk factor for chronic disease. Mesenchymal stem cells (MSCs) and exosomes have anti-inflammatory, pro-healing, and immunomodulatory effects that make them appealing candidates to reverse tissue and organ aging, improve overall organ function, and promote longevity. We hypothesized that treatment with MSCs and/or exosomes would improve the function of healthy mammalian organ systems and tissues, extend lifespan, and that treatment with stem cells from younger animals would have a greater rejuvenative effect than those from older animals. Through a review of the PubMed-indexed scientific literature, we sought to determine whether there is sound preclinical and/or clinical evidence to support these hypotheses. 34 preclinical studies were chosen as they demonstrated that stem cells and/or exosomes can restore bone density, improve muscle strength, significantly rejuvenate multiple organ systems, and increase longevity. Stem cell treatment appears to increase longevity, and both stem cell and exosome treatments are effective in rejuvenating and improving tissue and organ function in mammalian systems. Stem cells can extend overall mammalian lifespan. Transplantation of bone-marrow derived mesenchymal stem cells can restore bone density in mice. MSCs have a regenerative effect on aging muscles in mice. Both stem cells and exosomes have a rejuvenative effect on animal organ systems. Stem cells and exosomes improve organ function in the absence of pathological states.
SN  - 1422-0067
ER  -