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Peer-reviewedCC BYActa cirurgica brasileira

Exosome-mediated immunomodulatory and barrier-protective responses of adipose-derived mesenchymal stem cells in oleic acid-induced acute lung injury.

  • Gamze Ayar1
  • Badel Ince1
  • Kansu Buyukafsar1,2
  • Leyla Bahar1
  • Elif Onsoz1
  • Erkan Maytalman3
  • Mehmet Oguz Koksel4
4 affiliations
  1. 1Mersin University - Institute of Health Sciences - Department of Stem Cell and Regenerative Medicine - Mersin - Turkey.
  2. 2Mersin University - Faculty of Medicine - Department of Medical Pharmacology - Mersin - Turkey.
  3. 3Alanya Alaaddin Keykubat University - Faculty of Medicine - Department of Medical Pharmacology - Antalya - Turkey.
  4. 4Mersin University - Faculty of Medicine - Department of Thoracic Surgery - Mersin - Turkey.
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Abstract

Purpose

Acute lung injury (ALI) is a severe pulmonary disorder with limited treatment options. Mesenchymal stem cell-based therapies show regenerative and immunomodulatory potential, but the comparative efficacy of adipose-derived mesenchymal stem cells (ADMSCs) and their exosomes remains unclear. This study evaluated their therapeutic effects in an experimental ALI model.Methods

ADMSCs were isolated from rat adipose tissue and cultured under standard conditions. Exosomes were characterized by flow cytometry (CD9, CD63, CD81), scanning electron microscopy, dynamic light scattering, and zeta potential analysis. ALI was induced in Wistar Albino rats by intravenous administration of 60 mg/kg oleic acid. Treatments were administered 2.5 hours after injury. Lung tissues were examined histopathologically after 24 hours, and mRNA expression levels of interleukin (IL)-6, IL-10, and vascular endothelial growth factor (VEGF) were analyzed.Results

Both ADMSC and exosome treatments significantly reduced lung injury scores compared with the oleic acid group. ADMSCs demonstrated greater histopathological improvement than exosomes, although no significant differences were observed in IL-6, IL-10, or VEGF expression.Conclusion

Both ADMSCs and their exosomes showed therapeutic potential in ALI, with stem cells providing superior histopathological recovery.

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Cite

BibTeXRIS
BibTeX
@article{ayar2026exosomemediated,
  title = {{Exosome-mediated immunomodulatory and barrier-protective responses of adipose-derived mesenchymal stem cells in oleic acid-induced acute lung injury.}},
  author = {Gamze Ayar and Badel Ince and Kansu Buyukafsar and Leyla Bahar and Elif Onsoz and Erkan Maytalman and Mehmet Oguz Koksel},
  journal = {Acta cirurgica brasileira},
  year = {2026},
  month = oct,
  doi = {10.1590/acb416926},
  url = {https://europepmc.org/article/MED/42912009},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Exosome-mediated immunomodulatory and barrier-protective responses of adipose-derived mesenchymal stem cells in oleic acid-induced acute lung injury.
AU  - Gamze Ayar
AU  - Badel Ince
AU  - Kansu Buyukafsar
AU  - Leyla Bahar
AU  - Elif Onsoz
AU  - Erkan Maytalman
AU  - Mehmet Oguz Koksel
PY  - 2026
DA  - 2026/10/19
JO  - Acta cirurgica brasileira
DO  - 10.1590/acb416926
UR  - https://europepmc.org/article/MED/42912009
AB  - Purpose  Acute lung injury (ALI) is a severe pulmonary disorder with limited treatment options. Mesenchymal stem cell-based therapies show regenerative and immunomodulatory potential, but the comparative efficacy of adipose-derived mesenchymal stem cells (ADMSCs) and their exosomes remains unclear. This study evaluated their therapeutic effects in an experimental ALI model.Methods  ADMSCs were isolated from rat adipose tissue and cultured under standard conditions. Exosomes were characterized by flow cytometry (CD9, CD63, CD81), scanning electron microscopy, dynamic light scattering, and zeta potential analysis. ALI was induced in Wistar Albino rats by intravenous administration of 60 mg/kg oleic acid. Treatments were administered 2.5 hours after injury. Lung tissues were examined histopathologically after 24 hours, and mRNA expression levels of interleukin (IL)-6, IL-10, and vascular endothelial growth factor (VEGF) were analyzed.Results  Both ADMSC and exosome treatments significantly reduced lung injury scores compared with the oleic acid group. ADMSCs demonstrated greater histopathological improvement than exosomes, although no significant differences were observed in IL-6, IL-10, or VEGF expression.Conclusion  Both ADMSCs and their exosomes showed therapeutic potential in ALI, with stem cells providing superior histopathological recovery.
SN  - 0102-8650
SN  - 1678-2674
ER  -