Skip to content
DraconiticResearch
Search Sources API
197,768 studies31 sourcesUpdated 43 min ago
Peer-reviewedCC BY-NCThe journal of allergy and clinical immunology. Global

Guidelines for the management of adult penicillin allergy in community and specialist settings in Australia and New Zealand: An AGREE II and Delphi-based approach.

  • Michaela Lucas1,2,3,4,5,6,7
  • Jillian Kehoe1
  • Samantha Stiles1,8
  • Sandra M Salter7,9,10
  • Jacqueline Loprete7,10,11,12
  • Catherine J Hornung7,10,13
  • Lara Martin3
  • Syed B Ali14
  • Rani Scott Farmer7,13
  • Joseph DeLuca15
  • Suran Fernando16,17,18
  • Constance Katelaris19,20
9 more authors
  • Helen Kolawole21,22
  • Jason Trubiano7,15
  • Kirsten P Perrett7,10,22,23,24
  • William Smith1,3,25,26
  • Francis Thien3,22,27
  • Jennifer J Koplin7,10,13
  • Sandra Vale1,8
  • James Yun3,28,29
  • National Allergy Council Drug Allergy consortium∗
29 affiliations
  1. 1National Allergy Council, Sydney, Australia.
  2. 2Medical School, The University of Western Australia, Perth, Australia.
  3. 3Australasian Society of Clinical Immunology and Allergy, Sydney, Australia.
  4. 4Sir Charles Gardiner Hospital, Perth, Australia.
  5. 5Perth Children's Hospital, Perth, Australia.
  6. 6Pathwest Laboratory Medicine, Perth, Australia.
  7. 7National Allergy Centre of Excellence, Melbourne, Australia.
  8. 8School of Population and Global Health, The University of Western Australia, Perth, Australia.
  9. 9School of Health and Clinical Sciences, The University of Western Australia, Perth, Australia.
  10. 10Murdoch Children's Research Institute, Melbourne, Australia.
  11. 11St Vincent's Hospital Sydney, Sydney, Australia.
  12. 12School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, Australia.
  13. 13Child Health Research Centre, The University of Queensland, Brisbane, Australia.
  14. 14Department of Clinical Immunology and Allergy, Flinders Medical Centre, Adelaide, Australia.
  15. 15Austin Health, Melbourne, Australia.
  16. 16Royal North Shore Hospital, Sydney, Australia.
  17. 17Immunology Laboratory, Royal North Shore Hospital, New South Wales Health Pathology, Sydney, Australia.
  18. 18Northern Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
  19. 19Western Sydney University, Sydney, Australia.
  20. 20Campbelltown Hospital, Sydney, Australia.
  21. 21Peninsula University Hospital, Melbourne, Australia.
  22. 22Department of Anaesthesiology and Perioperative Medicine, Monash University, Melbourne, Australia.
  23. 23Department of Paediatrics, The University of Melbourne, Melbourne, Australia.
  24. 24Department of Allergy and Immunology, The Royal Children's Hospital, Melbourne, Australia.
  25. 25AllergySA, Adelaide, Australia.
  26. 26Royal Adelaide Hospital, Adelaide, Australia.
  27. 27Box Hill Hospital, Melbourne, Australia.
  28. 28Prince of Wales Hospital, Sydney, Australia.
  29. 29The University of New South Wales, Sydney, Australia.
Read full textPDFDOICite

Abstract

Background

This guideline was developed in collaboration with the Australasian Society of Clinical Immunology and Allergy (ASCIA), the National Allergy Council and the National Allergy Centre of Excellence (NACE). Despite the abundance of published penicillin allergy guidelines, few have been developed using rigorous evidence-based approaches such as the AGREE II framework.Objective

This guideline aims to provide recommendations for the assessment and management of adults with a penicillin allergy label, for Australian health professionals working in both community and specialist settings.Methods

The guideline was developed using the standardized, evidence-based AGREE II framework, consumer input, and a Delphi-based consensus process, involving a multidisciplinary panel of 27 drug allergy experts. Recommendations were informed by a rapid overview of reviews and existing guidelines.Results

A total of 37 recommendations reached consensus, covering risk stratification, testing protocols, challenge test outcomes, and communication and documentation process.Conclusions

These adult guidelines will support the implementation of penicillin allergy delabeling programs in community and specialist centers in Australia. As high-level evidence supporting many recommendations in this field remains limited, a Delphi-based expert consensus approach provides valuable guidance.

Related

  1. The Reported Prevalence of Micronutrient Deficiency after Metabolic Bariatric Surgery and Adherence to British Obesity and Metabolic Specialist Society Nutritional Guidelines: A Multicentre Retrospective Cohort Study
    Guy Holt, Sally Abbott, Charlotte Price +3
    Obesity SurgeryPeer-reviewedCC BY-NC-ND 4.0Full textSurgery & anaesthesiaPMC
  2. A Novel Informatics-Driven Model for Proactive Radiation Safety Management: Lessons from a Tumor Specialist Hospital in China.
    Qingqing Tian, Hui Wang, Hailin Zhang +3
    Risk management and healthcare policyPeer-reviewedCC BY-NCFull textMedical imaging & radiologyEurope PMC
  3. Specialist-led community-based cardio-kidney-metabolic-pulmonary care in high-risk individuals: multi-centre pragmatic prospective randomized open-label blinded endpoint trial.
    Ramesh Nadarajah, Ali Wahab, Ben Hurdus +10
    European heart journal openPeer-reviewedCC BYFull textEpidemiology & public healthEurope PMCPMC
  4. Why are there so many different guidelines? A qualitative study of the low back pain policy landscape in Australia.
    Sarika Parambath, Carmen Huckel Schneider, Fiona Blyth
    BMC musculoskeletal disordersPeer-reviewedCC BY-NC-NDFull textEpidemiology & public healthEurope PMCPMC
  5. A scoping review of caries risk management protocols in Australia and New Zealand
    N Amarasena, D Haag, Kg Peres
    Australian Dental JournalPeer-reviewedLicence not statedFull text4 citedGeneral biologyEpidemiology & public healthHAL

Cite

BibTeXRIS
BibTeX
@article{lucas2026guidelines,
  title = {{Guidelines for the management of adult penicillin allergy in community and specialist settings in Australia and New Zealand: An AGREE II and Delphi-based approach.}},
  author = {Michaela Lucas and Jillian Kehoe and Samantha Stiles and Sandra M Salter and Jacqueline Loprete and Catherine J Hornung and Lara Martin and Syed B Ali and Rani Scott Farmer and Joseph DeLuca and Suran Fernando and Constance Katelaris and Helen Kolawole and Jason Trubiano and Kirsten P Perrett and William Smith and Francis Thien and Jennifer J Koplin and Sandra Vale and James Yun and National Allergy Council Drug Allergy consortium∗},
  journal = {The journal of allergy and clinical immunology. Global},
  year = {2026},
  month = oct,
  doi = {10.1016/j.jacig.2026.100784},
  url = {https://europepmc.org/article/MED/42908540},
  note = {CC BY-NC},
}
RIS
TY  - JOUR
TI  - Guidelines for the management of adult penicillin allergy in community and specialist settings in Australia and New Zealand: An AGREE II and Delphi-based approach.
AU  - Michaela Lucas
AU  - Jillian Kehoe
AU  - Samantha Stiles
AU  - Sandra M Salter
AU  - Jacqueline Loprete
AU  - Catherine J Hornung
AU  - Lara Martin
AU  - Syed B Ali
AU  - Rani Scott Farmer
AU  - Joseph DeLuca
AU  - Suran Fernando
AU  - Constance Katelaris
AU  - Helen Kolawole
AU  - Jason Trubiano
AU  - Kirsten P Perrett
AU  - William Smith
AU  - Francis Thien
AU  - Jennifer J Koplin
AU  - Sandra Vale
AU  - James Yun
AU  - National Allergy Council Drug Allergy consortium∗
PY  - 2026
DA  - 2026/10/12
JO  - The journal of allergy and clinical immunology. Global
DO  - 10.1016/j.jacig.2026.100784
UR  - https://europepmc.org/article/MED/42908540
AB  - Background  This guideline was developed in collaboration with the Australasian Society of Clinical Immunology and Allergy (ASCIA), the National Allergy Council and the National Allergy Centre of Excellence (NACE). Despite the abundance of published penicillin allergy guidelines, few have been developed using rigorous evidence-based approaches such as the AGREE II framework.Objective  This guideline aims to provide recommendations for the assessment and management of adults with a penicillin allergy label, for Australian health professionals working in both community and specialist settings.Methods  The guideline was developed using the standardized, evidence-based AGREE II framework, consumer input, and a Delphi-based consensus process, involving a multidisciplinary panel of 27 drug allergy experts. Recommendations were informed by a rapid overview of reviews and existing guidelines.Results  A total of 37 recommendations reached consensus, covering risk stratification, testing protocols, challenge test outcomes, and communication and documentation process.Conclusions  These adult guidelines will support the implementation of penicillin allergy delabeling programs in community and specialist centers in Australia. As high-level evidence supporting many recommendations in this field remains limited, a Delphi-based expert consensus approach provides valuable guidance.
SN  - 2772-8293
ER  -