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Peer-reviewedCC BY-NC-NDACS nanoscience Au

Spin-Uniform Nanodiamond Quantum Sensors for Reproducible Intracellular Thermometry.

  • Chihiro Suzuki1,2
  • Tamami Yanagi3
  • Risa Ujiie1
  • Masanori Fujiwara4
  • Izuru Ohki4
  • Hiroshi Abe5
  • Shinobu Onoda5
  • Takeshi Ohshima5
  • Norikazu Mizuochi4
  • Kiichi Kaminaga1,6
  • Ryuji Igarashi1,3
6 affiliations
  1. 1Institute for Quantum Life Science, National Institutes for Quantum Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.
  2. 2Graduate School of Science and Engineering, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-0022, Japan.
  3. 3School of Life Science and Technology, Institute of Science Tokyo, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan.
  4. 4Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan.
  5. 5Quantum Materials and Applications Research Center, National Institutes for Quantum Science and Technology, 1233 Watanuki-machi, Takasaki City, Gunma 370-1292, Japan.
  6. 6Type-I Technologies Inc., 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.
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Abstract

Nanodiamond quantum sensors have been regarded as promising probes for cellular thermometry, but their poor sensor-to-sensor reproducibility has hindered practical implementation. In cellular measurements, the resulting temperature-readout offsets can be mistaken for real cell-to-cell temperature differences, limiting quantitative comparison. Here, we show that spin-uniform nitrogen vacancy (NV)-rich nanodiamonds can be produced via postenrichment oxidative size reduction, which removes defective surface layers while improving crystallinity. Compared with nanodiamonds prepared by conventional mechanical milling before NV enrichment, the particle-to-particle spread in the temperature-sensitive D values was reduced by 3.7-fold. The improved NV homogeneity also enhanced spin properties: the optically detected magnetic resonance contrasta key signal amplitude for sensitivityincreased by more than 50%. Together, these improvements reduce cell-to-cell dispersion in D-derived single-cell temperature readouts to below 0.7 K, enabling reliable temperature comparison across cells. This approach advances nanodiamond absolute thermometry toward organelle-scale intracellular temperature mapping and practical quantum sensing in biology and medicine.

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Cite

BibTeXRIS
BibTeX
@article{suzuki2026spinuniform,
  title = {{Spin-Uniform Nanodiamond Quantum Sensors for Reproducible Intracellular Thermometry.}},
  author = {Chihiro Suzuki and Tamami Yanagi and Risa Ujiie and Masanori Fujiwara and Izuru Ohki and Hiroshi Abe and Shinobu Onoda and Takeshi Ohshima and Norikazu Mizuochi and Kiichi Kaminaga and Ryuji Igarashi},
  journal = {ACS nanoscience Au},
  year = {2026},
  month = oct,
  doi = {10.1021/acsnanoscienceau.6c00068},
  url = {https://europepmc.org/article/MED/42921275},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Spin-Uniform Nanodiamond Quantum Sensors for Reproducible Intracellular Thermometry.
AU  - Chihiro Suzuki
AU  - Tamami Yanagi
AU  - Risa Ujiie
AU  - Masanori Fujiwara
AU  - Izuru Ohki
AU  - Hiroshi Abe
AU  - Shinobu Onoda
AU  - Takeshi Ohshima
AU  - Norikazu Mizuochi
AU  - Kiichi Kaminaga
AU  - Ryuji Igarashi
PY  - 2026
DA  - 2026/10/06
JO  - ACS nanoscience Au
DO  - 10.1021/acsnanoscienceau.6c00068
UR  - https://europepmc.org/article/MED/42921275
AB  - Nanodiamond quantum sensors have been regarded as promising probes for cellular thermometry, but their poor sensor-to-sensor reproducibility has hindered practical implementation. In cellular measurements, the resulting temperature-readout offsets can be mistaken for real cell-to-cell temperature differences, limiting quantitative comparison. Here, we show that spin-uniform nitrogen vacancy (NV)-rich nanodiamonds can be produced via postenrichment oxidative size reduction, which removes defective surface layers while improving crystallinity. Compared with nanodiamonds prepared by conventional mechanical milling before NV enrichment, the particle-to-particle spread in the temperature-sensitive D values was reduced by 3.7-fold. The improved NV homogeneity also enhanced spin properties: the optically detected magnetic resonance contrasta key signal amplitude for sensitivityincreased by more than 50%. Together, these improvements reduce cell-to-cell dispersion in D-derived single-cell temperature readouts to below 0.7 K, enabling reliable temperature comparison across cells. This approach advances nanodiamond absolute thermometry toward organelle-scale intracellular temperature mapping and practical quantum sensing in biology and medicine.
SN  - 2694-2496
ER  -