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Peer-reviewedCC BY-NC-NDRegenerative therapy

Platelet-related extracellular vesicles: Therapeutic roles in musculoskeletal disorders.

  • Tianjiao Meng1
  • Yuhan Wang2
  • Xiaoyong Tang3
  • Jie Xiong1
  • Shan Hu3
  1. 1Department of Blood Transfusion, Ya an People's Hospital, Ya an, 625100, China.
  2. 2Department of Clinical Laboratory, Lu zhou long ma tan District People's Hospital, Lu zhou, 646000, China.
  3. 3Department of Blood Transfusion, Guang han People's Hospital, De yang, 618300, China.
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Abstract

Musculoskeletal disorders are a major cause of pain, disability, and loss of function. Platelet-rich plasma (PRP) has been widely investigated for musculoskeletal repair, and interest has increasingly extended to extracellular vesicle (EV) preparations obtained from platelet-related starting materials. These include EV-enriched preparations collected from isolated platelets or defined platelet concentrates (P-EVs), from PRP (PRP-EVs), and from platelet lysate (PL-EVs). They do not represent the same biological product. Their cellular contributors, co-isolated soluble components, and molecular composition can differ substantially, and the name of the starting material does not prove the origin of every vesicle in the preparation. Preclinical studies nevertheless suggest that these EV preparations can influence inflammatory responses, cartilage metabolism, tendon-cell behavior, and the local repair environment. The strength of this evidence varies with the source material, separation and characterization methods, experimental model, and delivery strategy. This review examines the therapeutic evidence for platelet-related EV preparations in musculoskeletal disorders, while keeping P-EVs, PRP-EVs, PL-EVs, and plasma-derived EVs distinct and considering the methodological limitations that currently restrict comparison and clinical translation.

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Cite

BibTeXRIS
BibTeX
@article{meng2026plateletrelated,
  title = {{Platelet-related extracellular vesicles: Therapeutic roles in musculoskeletal disorders.}},
  author = {Tianjiao Meng and Yuhan Wang and Xiaoyong Tang and Jie Xiong and Shan Hu},
  journal = {Regenerative therapy},
  year = {2026},
  month = oct,
  doi = {10.1016/j.reth.2026.101188},
  url = {https://europepmc.org/article/MED/42927200},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Platelet-related extracellular vesicles: Therapeutic roles in musculoskeletal disorders.
AU  - Tianjiao Meng
AU  - Yuhan Wang
AU  - Xiaoyong Tang
AU  - Jie Xiong
AU  - Shan Hu
PY  - 2026
DA  - 2026/10/16
JO  - Regenerative therapy
DO  - 10.1016/j.reth.2026.101188
UR  - https://europepmc.org/article/MED/42927200
AB  - Musculoskeletal disorders are a major cause of pain, disability, and loss of function. Platelet-rich plasma (PRP) has been widely investigated for musculoskeletal repair, and interest has increasingly extended to extracellular vesicle (EV) preparations obtained from platelet-related starting materials. These include EV-enriched preparations collected from isolated platelets or defined platelet concentrates (P-EVs), from PRP (PRP-EVs), and from platelet lysate (PL-EVs). They do not represent the same biological product. Their cellular contributors, co-isolated soluble components, and molecular composition can differ substantially, and the name of the starting material does not prove the origin of every vesicle in the preparation. Preclinical studies nevertheless suggest that these EV preparations can influence inflammatory responses, cartilage metabolism, tendon-cell behavior, and the local repair environment. The strength of this evidence varies with the source material, separation and characterization methods, experimental model, and delivery strategy. This review examines the therapeutic evidence for platelet-related EV preparations in musculoskeletal disorders, while keeping P-EVs, PRP-EVs, PL-EVs, and plasma-derived EVs distinct and considering the methodological limitations that currently restrict comparison and clinical translation.
SN  - 2352-3204
ER  -