Slow-SPEED: protocol for three randomised trials of remotely delivered exercise to prevent Parkinson’s disease

@article{oosterhof2026slowspeed,
  title = {{Slow-SPEED: protocol for three randomised trials of remotely delivered exercise to prevent Parkinson’s disease}},
  author = {Thomas H. Oosterhof and Eleanor Mitchell and Alberto Ascherio and Stella Aslibekyan and Viktoria Azoidou and Kara Beasley and Yoav Ben-Shlomo and Eline Bunnik and Camille Carroll and Lana Chahine and Daniel Corcos and Jules M. Janssen Daalen and Karin D. van Dijk and Bauke W. Dijkstra and Lisanne Dommershuijsen and Ray Dorsey and Luc J. W. Evers and Rick C. Helmich and Martin Johansson and Lucy Norcliffe-Kaufmann and Jessi Keavney and Christine Klein and Matthew J. Kmiecik and Thomas Kustermann and Eric A. Macklin and Kenneth Marek and Sanne K. Meles and Sebastiaan Overeem and Carl M. Philpott and Angelique Pijpers and Ronald B. Postuma and Helen M. Rowbotham and Sabine Schootemeijer and Michael A. Schwarzschild and Tanya Simuni and Michael Sommerauer and Ambra Stefani and Kenan Steidel and Marcel Verbeek and Rick van der Vliet and Nienke M. de Vries and Bart van de Warrenburg and Richard K. Wyse and Bastiaan R. Bloem and Ruth B. Schneider and Alastair J. Noyce and Sirwan K. L. Darweesh},
  journal = {NPJ Parkinson's Disease},
  year = {2026},
  month = jul,
  doi = {10.1038/s41531-026-01463-z},
  url = {https://doi.org/10.1038/s41531-026-01463-z},
  note = {CC BY 4.0},
}

TY  - JOUR
TI  - Slow-SPEED: protocol for three randomised trials of remotely delivered exercise to prevent Parkinson’s disease
AU  - Thomas H. Oosterhof
AU  - Eleanor Mitchell
AU  - Alberto Ascherio
AU  - Stella Aslibekyan
AU  - Viktoria Azoidou
AU  - Kara Beasley
AU  - Yoav Ben-Shlomo
AU  - Eline Bunnik
AU  - Camille Carroll
AU  - Lana Chahine
AU  - Daniel Corcos
AU  - Jules M. Janssen Daalen
AU  - Karin D. van Dijk
AU  - Bauke W. Dijkstra
AU  - Lisanne Dommershuijsen
AU  - Ray Dorsey
AU  - Luc J. W. Evers
AU  - Rick C. Helmich
AU  - Martin Johansson
AU  - Lucy Norcliffe-Kaufmann
AU  - Jessi Keavney
AU  - Christine Klein
AU  - Matthew J. Kmiecik
AU  - Thomas Kustermann
AU  - Eric A. Macklin
AU  - Kenneth Marek
AU  - Sanne K. Meles
AU  - Sebastiaan Overeem
AU  - Carl M. Philpott
AU  - Angelique Pijpers
AU  - Ronald B. Postuma
AU  - Helen M. Rowbotham
AU  - Sabine Schootemeijer
AU  - Michael A. Schwarzschild
AU  - Tanya Simuni
AU  - Michael Sommerauer
AU  - Ambra Stefani
AU  - Kenan Steidel
AU  - Marcel Verbeek
AU  - Rick van der Vliet
AU  - Nienke M. de Vries
AU  - Bart van de Warrenburg
AU  - Richard K. Wyse
AU  - Bastiaan R. Bloem
AU  - Ruth B. Schneider
AU  - Alastair J. Noyce
AU  - Sirwan K. L. Darweesh
PY  - 2026
DA  - 2026/07/14
JO  - NPJ Parkinson's Disease
DO  - 10.1038/s41531-026-01463-z
UR  - https://doi.org/10.1038/s41531-026-01463-z
AB  - We describe the design of the first non-pharmacological Parkinson’s disease prevention trials worldwide: the randomised ‘Slow-SPEED’ trials. Three trials examine the feasibility and preliminary efficacy of a gamified, remotely administered exercise intervention vs. active control over 18–36 months in complementary prodromal subgroups: iRBD(n = 110; Netherlands), hyposmia(n = 110; United Kingdom) or LRRK2/GBA1 mutation carriers(n = 600; United States). These trials will provide unique insights for large-scale Parkinson’s prevention studies. Protocols are registered at ClinicalTrials.gov(NCT06193252[1-5-2024];NCT06600438[9-19-2024];NCT06993142[5-28-2025]).
SN  - 2373-8057
ER  -